A5103074053- Carcinogens and Genotoxicity Assessment
- Vitamin C and Antioxidants Research
- Inhalation and Respiratory Drug Delivery
- Acute Lymphoblastic Leukemia research
- DNA Repair Mechanisms
- Asthma and respiratory diseases
- Spaceflight effects on biology
- Synthesis and pharmacology of benzodiazepine derivatives
- Flavonoids in Medical Research
- Genomics, phytochemicals, and oxidative stress
- Synthesis and bioactivity of alkaloids
- Chemotherapy-induced organ toxicity mitigation
- Chemical Analysis and Environmental Impact
- Cancer-related Molecular Pathways
- Drug Solubulity and Delivery Systems
- Nigella sativa pharmacological applications
- Cancer, Stress, Anesthesia, and Immune Response
- Multiple Myeloma Research and Treatments
- Effects and risks of endocrine disrupting chemicals
- Bone health and treatments
- Cardiac Ischemia and Reperfusion
- Curcumin's Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Pulmonary Hypertension Research and Treatments
- Long-Term Effects of COVID-19
University of Bradford
2008-2024
PSG Institute of Medical Sciences & Research
2017-2018
Rajendra Hospital
2017
The present study has examined the effects of ZnO and TiO2 nanoparticles (40–70 nm range) in presence absence UVA light human sperm lymphocytes dark (D), after pre-irradiation with UV (PI) simultaneous irradiation (SI). For both nanoparticles, percentage reduction head DNA was greater for PI SI samples compared treated dark. However regard to photogenotoxicity, exhibited no significant differences when results were compared, except at lowest concentration case TiO2. lymphocytes, responses...
Epigallocatechin gallate (EGCG), the main ingredient in green tea, holds promise as a potential treatment for pulmonary arterial hypertension (PAH). However, EGCG has many drawbacks, including stability issues, low bioavailability, and short half-life. Therefore, purpose of this research was to develop optimize an inhalable nano-liposome formulation aiming overcome EGCG's drawbacks by applying design experiments strategy. The aerodynamic behaviour optimum determined using next-generation...
Lymphocyte responses from 208 individuals: 20 with melanoma, 34 colon cancer, and 4 lung cancer (58), 18 suspected 28 polyposis, 10 COPD (56), 94 healthy volunteers were examined. The natural logarithm of the Olive tail moment (OTM) was plotted for exposure to UVA through 5 different agar depths (100 cell measurements/depth) analyzed using a repeated measures regression model. Responses patients plateaued after treatment intensities, but returned toward control values volunteers. For...
To use lymphocytes as surrogate cells to investigate their in vitro sensitivities ultraviolet (UV) treatment different cancers and precancerous states by comparison with from healthy control individuals was the main aim of this research. UV light induces precise cellular genomic mutations. In study, effect A (UVA) (320–400 nm) used a generic mutagen evaluate patients suspected melanoma (SM), malignant (MM), polyposis coli (PC) colorectal cancer (CRC). DNA damage evaluated two methods:...
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit COX enzyme activity which affects the inflammatory response. Inflammation is associated with increasing cancer incidence. Pre-clinical and clinical studies have shown that NSAID treatment could cause an anti-tumor effect in cancers. In present study, blood was taken from healthy individuals (n = 17) patients respiratory diseases or lung 36). White cells (WBC) were treated either a micro-suspension, i.e., bulk (B) nano-suspension (N) of...
We investigated the protective role of myricetin bulk and nanoforms, against reactive oxygen species (ROS)-induced oxidative stress caused by hydrogen peroxide tertiary-butyl hydro in lymphocytes vitro from healthy individuals those pre-cancerous patients suffering with monoclonal gammopathy undetermined significance (MGUS). The change intracellular was measured once cells were treated forms nanoforms without either or co-supplementation. direct indirect antioxidant activity...
Abstract Evading apoptosis and chemo-resistance are considered as very important factors which help tumour progression metastasis. Hence, to overcome chemo-resistance, there is an urgent requirement for emergence of more effective treatment options. Myricetin, a naturally occurring flavonoid, present in various plant-derived foods shows antitumour potential different cancers. In the vitro study, results from comet assay demonstrated that myricetin bulk (10 µM) nano (20 forms exhibited...
Pulmonary arterial hypertension (PAH) is a progressive and rare condition characterised by the occlusion of pulmonary arterioles, with clinical manifestations resulting from cross-sectional area reduction small arteries. The disease driven combination factors including vasoconstriction, thrombosis, inflammation, proliferation, obstructive remodelling artery walls. Heterozygous mutations in type II bone morphogenetic protein receptor (BMPR2) underlie majority inherited familial forms PAH....
Abstract 2-Amino-1-methyl-6-phenylimidazo [4,5- b ]pyridine (PhIP) is a central dietary mutagen, produced when proteinaceous food heated at very high temperatures potentially causing DNA strand breaks. This study investigates the protective potential of well-researched flavonoid, myricetin in its bulk and nano-forms against oxidative stress induced ex vivo / vitro by PhIP lymphocytes from pre-cancerous monoclonal gammopathy undetermined significance (MGUS) patients those healthy individuals....
Background: Oxidative stress has been linked to heart failure (HF) in humans. Antioxidant-based treatments are not always effective. Hence, we tested a hypothesis that some patients with may have hyper-reductive state. Identifying this condition lead personalized optimization and better outcomes. Methods: Blood samples were collected from age sex matched healthy control (n=50) HF (n=55). Serum was separated stored immediately -80°C until analysis. Reduced glutathione (GSH) its redox ratio...
Abstract Background Oxidative stress has been linked to heart failure (HF) in humans. Antioxidant-based treatments are often ineffective. Therefore, we hypothesize that some of the HF patients might have a reductive (RS) condition. Investigating RS-related mechanisms will aid personalized optimization redox homeostasis for better outcomes among patients. Methods Blood samples were collected from (n=54) and healthy controls (n=42) serum was immediately preserved –80°C analysis....