A5056828649- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Dementia and Cognitive Impairment Research
- Nutrition, Genetics, and Disease
- Renal and Vascular Pathologies
- Cardiac Imaging and Diagnostics
- Healthcare Systems and Public Health
- Heart Rate Variability and Autonomic Control
- Renal cell carcinoma treatment
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Viral Infections and Immunology Research
- Acute Ischemic Stroke Management
- Cardiovascular Syncope and Autonomic Disorders
- Peripheral Artery Disease Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Infective Endocarditis Diagnosis and Management
- Science, Research, and Medicine
- Calpain Protease Function and Regulation
- ECG Monitoring and Analysis
- Cardiovascular Function and Risk Factors
- Cancer Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Arrest and Resuscitation
ICU Medical (United States)
2025
Ministry of Interior
2024
Sofia University "St. Kliment Ohridski"
2013-2023
Acibadem City Clinic
2023
Medical University of Sofia
2011-2022
Alexandrovska Hospital
2012-2013
Objective Patients with suboptimal blood pressure (BP) control may remain an elevated cardiovascular risk and for cognitive impairment. Pulse (PP) assessed ambulatory BP monitoring (ABPM) or self-measurement so far has been underestimated factor target organ damage. Methods One hundred forty-eight patients were screened: 51 men (34.5%) 97 women (65.5%), mean age 64.16 ± 11.18 years a hypertension history of 13.1 11.05 years. We gathered full medical history, physical examination, laboratory...
Abstract People with mild cognitive impairment (MCI) may be at higher risk of death than normal aging ones. On the other hand, patients cardiovascular factors are also death. It logical to question then if combination MCI and cardio-vascular (in most cases arterial hypertension) can lead mortality rate expected both for high general population. This hypothesis is important in light effective early screening prophylaxis. The very high-cardio-vascular-risk was compared subgroups cognition MCI....
Aim: Cardiovascular risk factors are also for cognitive impairment. They have cumulative effect in target organ damage. The precise correlation between cardiovascular and impairment, as well assessing the extent to which they may affect functioning, is difficult ascertain everyday clinical practice. Quick, specific, sensitive neuropsychological tests be useful screening for, prophylaxis of, damage hypertensive patients. Methods: We gathered full anamnesis, performed physical examination,...
We aim to analyze if there is any correlation between suboptimal home-/self-measured blood pressure values and the results from neuropsychological screening tests for early cognitive impairment.We studied 325 patients with treated hypertension. Mean age was 66.12 (±10.1) years. There were 119 (36.6%) male 206 (63.4%) female patients, among them 52 (16%) atrial fibrillation. Neuropsychological performed Mini-Mental State Examination, Montreal Cognitive Assessment, Hachinski Ischemic Score;...
We compared the role of central blood pressure (BP), ambulatory BP monitoring (ABPM), home-measured (HMBP) and office measurement as risk markers for development mild cognitive impairment (MCI).70 hypertensive patients on combination medical therapy were studied. Their mean age was 64.97 ± 8.88 years. Eighteen (25.71%) males 52 (74.28%) females. All underwent full physical examination, laboratory screening, echocardiography, office, ambulatory, home measurement. The neuropsychological tests...
Objective: Poorly controlled blood pressure is a risk factor for the development of mild cognitive impairment (MCI). It still unclear whether circadian rhythm plays any role incidence MCI and precisely what. Design method: This cross-sectional study 439 hypertensive patients. The mean age was 64.65 ± 10.15 years; males 160 (36.4%); females 279 (63.6%). hypertension history 11.10 9.34 years. All were on combination medical therapy. patients underwent full history, physical examination,...
There is data that ApoE may play an important role for patients with vascular type of dementia and the earlier development Alzheimer's dementia. On other hand cardio-vascular risk factors be cornerstone clinic both types dementias. We tested hypothesis whether ApoE4 or cardiovascular are leading factor clinical presentation mild cognitive impairment. 108 hypertension were included in this prospective study:27(25%) males 81(75%) females. The mean age was 67,82±8,78 years. 22.22% smokers;...
In patients with arterial hypertension non-valvular atrial fibrillation may raise the risk for mild cognitive impairment despite use of anticoagulation therapy. 953 and concomitant cardiovascular factors were included in study. 359 (37.67%) males 594 (62.32%) - females. The mean age was 66.05±9.96 years. 130 (13.64%) them optimal during inclusion visit. They underwent neuropsychological testing Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Hachinski ischemic...
Introduction : Carotid stenting may produce significant bradycardia and/or hypotension. This have negative short- and long-term effects for the elderly high-risk patients. Their cerebral hemodynamics is with exhausted adaptive capacity because of multiple cardiovascular risk factors, advanced age, stenosis. Aim was a retrospective study aimed at finding whether periprocedural hypoperfusion or hypotension time carotid had any significance acute neurological outcome mid-term general mortality...
Not available Keywords: electrocardiogramechocardiographyacute ischemiacascade
Cardio-vascular risk factors play an important role in the development and progression of mild cognitive impairment (MCI). Their negative effect may be cumulative. Earlier studies our group concluded that arterial hypertension is factor for MCI. The simultaneous presentation diabetes mellitus a single patient lead to higher incidence 931 patients with were included initial screening MCI: males 347 (37.27%) females 584 (62.73%). mean age was 65.90±10.00 years. 263 (28.25%) reevaluated after...
Purpose: Patients with isolated office or ambulatory hypertension are at an elevated cardio-vascular risk than the general population. The purpose of this study is to evaluate for cognitive impairment in patients white-coat masked hypertension, and compare it other hypertensive patients. Methods: A prospective 953 on combination therapy. Mean age was 66.01±9.98 years. 359 (37.67%) were males 594 (62.32%) females. 269 (28.23%) reevaluated after a mean period 12 months (min.6 max.20). Blood...
a hereditary component of the disease and subsequent screening relatives can help identify first-line at risk.
Objective: Fibromuscular dysplasia (FMD) is a relatively rare reason for secondary hypertension, predominantly in young women. Intravascular ultrasound (IVUS) plays potentially important role defining the precise type of FMD and to properly direct treatment – balloon PTA. This may lead better results. Design method: clinical case 25 year old woman. She was with arterial hypertension last 3 years, maximal values 200/100 mmHg, self measured on centrally acting medication 130/80 mmHg....
Background: Mitral valve resistance (MVR) is a hemodynamic consequence of mitral stenosis but it has no clear threshold and shortage data to be reliable. Purpose: investigate match mismatch between opening area especially in patients with moderate mild stenosis. Materials: This cross section case control study comprised 88 rheumatic Transthorathic echocardiographic estimated: (MVA) both by planimerty (2D) pressure half time (PHT), score (MVS), mean transmitral gradient (MPG), diastolic...
Objective: One of the major risk factors for mild cognitive impairment (MCI) is arterial hypertension. Hypertension induced changes in one target organ may correspond to others. That be great importance assessment everyday practice. We tried find if there correlation between MCI and left ventricular hypertrophy (LVH) as manifestations hypertensive damage different organs. Design method: 931 patients, mean age 65.90 ± 10.00 years, underwent complete physical examination, office home blood...
Objective: To investigate for the first time in South-Eastern population possible association of seven polymorphic variants from genome-wide studies (GWASs) with essential hypertension (EH): rs890283, rs2229238, rs1173771, rs9349379, rs3918226, rs2681472, rs579459, or near genes CYP2J2, IL6R, NPR3 - C5orf23, PHACTR1, eNOS, ATP2B1, ABO, respectively, and to further explore epistasis interactions that are involved pathophysiology high blood pressure. Design method: 794 Bulgarian subjects were...