A5076551053- Angiogenesis and VEGF in Cancer
- Skin Protection and Aging
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Asthma and respiratory diseases
- Nonmelanoma Skin Cancer Studies
- Hedgehog Signaling Pathway Studies
- Immune Cell Function and Interaction
- Cancer and Skin Lesions
- Dermatology and Skin Diseases
- Inflammatory mediators and NSAID effects
- Pituitary Gland Disorders and Treatments
- Immunotherapy and Immune Responses
- Diverse academic and cultural studies
- Vascular Malformations and Hemangiomas
- Inflammasome and immune disorders
- Tumors and Oncological Cases
- Psoriasis: Treatment and Pathogenesis
- Long-Term Effects of COVID-19
- Vascular Malformations Diagnosis and Treatment
- Management, Economics, and Public Policy
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- Developmental Biology and Gene Regulation
- Acute Ischemic Stroke Management
- Retinoids in leukemia and cellular processes
University of Toronto
2005-2012
Johns Hopkins University
2002-2005
Johns Hopkins Medicine
2003-2005
Georgia Cancer Specialists
2005
Sunnybrook Health Science Centre
2000
Abstract The role of CD4+ vs CD8+ T cells in contact hypersensitivity (CHS) remains controversial. In this study, we used gene knockout (KO) mice deficient or to directly address issue. Mice lacking either demonstrated depressed CHS responses dinitrofluorobenzene and oxazolone compared with wild-type C57BL/6 mice. depression was more significant CD8 KO than CD4 Furthermore, vivo depletion from virtually abolished responses. Lymph node (LNCs) hapten-sensitized showed a decreased capacity for...
<h3>SUMMARY:</h3> Coronavirus disease 2019 (COVID-19) is associated with a severe inflammatory response. Inflammation affects atherosclerotic plaque vulnerability and promotes thrombogenic environment. We report series of 6 patients COVID-19 acute ischemic stroke due to intraluminal carotid artery thrombus presenting during an 8-day period. Six were included (5 men) mean age 65.8 years (range, 55–78 years). was diagnosed by detection Severe Acute Respiratory Syndrome coronavirus 2 in 5...
The epidermal Langerhans cells (LC), a member of the dendritic cell family, and LC-derived cytokine IL-12 play pivotal role in initiation contact hypersensitivity (CHS), Th1 immune response skin. Because IL-18, another cytokine, shares functional biological properties with IL-12, we examined potential for IL-18 CHS initiation. Our studies demonstrated that during induction phase murine CHS, mRNA was significantly up-regulated skin-draining lymph nodes (LN). Migratory hapten-modified LC LN...
The angiogenic mediator vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) have been studied extensively in neoplastic disease some inflammatory conditions. Contact hypersensitivity (CHS) is a prototypic Langerhans' cell-dependent, T-helper (Th) 1 cell-mediated skin that now also thought to involve mediators. purpose of our study was examine the role angiogenesis VEGF CHS. We demonstrated production up-regulated murine after challenge with dinitrofluorobenzene....
Abstract: Basal cell carcinoma (BCC) is the most common cutaneous malignancy that, like other tumours, possesses a heterogeneous genetic composition. In order to select genes with consistent changes in expression among these we analysed BCC microarray data by using novel approach, termed correlative analysis of microarrays (CAM). CAM nested, non‐parametric method designed qualitatively candidates based on their individual, similar effects upon an array‐wide closeness measure. We applied...
Background: Æ-941 (Neovastat) is an angiogenesis inhibitor noted to have antiinflammatory properties. Objective: We tested Neovastat in a contact hypersensitivity (CHS) model determine the mechanism of action its effects. Methods: was orally administered (200 mg/kg/day) during sensitization and challenge phases murine CHS assay inflammatory responses were measured. Subsequent assays performed on mice treated with or Cortisone (120 mg/kg/day, IP) differential mRNA expression several pro-...
Background: Æ-941 (Neovastat) is an angiogenesis inhibitor noted to have antiinflammatory properties. Objective: We tested Neovastat in a contact hypersensitivity (CHS) model determine the mechanism of action its effects. Methods: was orally administered (200 mg/kg/day) during sensitization and challenge phases murine CHS assay inflammatory responses were measured. Subsequent assays performed on mice treated with or Cortisone (120 mg/kg/day, IP) differential mRNA expression several pro-...
7270 Background: Bexarotene, a specific synthetic retinoid analogue, binds to the α, β, and γ subclass of RXR, providing therapeutic specificity reduced toxicities in pts with RXR-expressing tumors. Initial phase-I/II clinical trials NSCLC showed that bexarotene added chemotherapy prolonged stabilization disease (TTP) 1, 2, 3 yr survival. Methods: Stage IIIB pleural effusion & IV chemo-naïve patients, ECOG PS 0–2, were enrolled on study treated carboplatin AUC-6 d1 paclitaxel 100mg/m2 d1, 8,...