A5059072239- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Muscle and Compartmental Disorders
- Cerebrovascular and Carotid Artery Diseases
- Infectious Aortic and Vascular Conditions
- Central Venous Catheters and Hemodialysis
- Vascular Malformations Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Mechanical Circulatory Support Devices
- Acute Ischemic Stroke Management
- Immune Cell Function and Interaction
- Lipoproteins and Cardiovascular Health
Yale University
2020-2022
Arteriovenous fistulae (AVF) are the preferred vascular access for hemodialysis, but primary success rate of AVF remains poor. Successful maturation requires wall thickening and outward remodeling. A key factor determining successful is inflammation that characterized by accumulation both T-cells macrophages. We have previously shown anti-inflammatory (M2) macrophages critically important during venous remodeling; therefore, regulation macrophage may be an mechanism promoting maturation....
Patients with end-stage renal failure depend on hemodialysis indefinitely without transplantation, requiring a long-term patent vascular access. While the arteriovenous fistula (AVF) remains preferred access for because of its longer patency and fewer complications compared other accesses, primary AVF is only 50-60%, presenting clinical need improvement. mature by developing thickened wall increased diameter to adapt arterial blood pressure flow volume. Inflammation plays critical role...
Patients with end-stage renal disease depend on hemodialysis for survival. Although arteriovenous fistulae (AVF) are the preferred vascular access hemodialysis, primary success rate of AVF is only 30% to 50% within 6 months, showing an urgent need improvement. PD-L1 (programmed death ligand 1) a that regulates T-cell activity. Since T cells have important role during maturation, we hypothesized control venous remodeling occurs maturation. Approach and results: In mouse aortocaval fistula...