A5066763846- Advanced Radiotherapy Techniques
- Radiation Effects and Dosimetry
- Nuclear Physics and Applications
- Radiation Detection and Scintillator Technologies
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Management, Economics, and Public Policy
- Diverse academic and cultural studies
- Prostate Cancer Diagnosis and Treatment
- Free Radicals and Antioxidants
- Electron Spin Resonance Studies
- Lanthanide and Transition Metal Complexes
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Cruise Tourism Development and Management
- Family Business Performance and Succession
- Boron Compounds in Chemistry
- RNA Interference and Gene Delivery
- Electrical and Bioimpedance Tomography
- Maritime Ports and Logistics
- Curcumin's Biomedical Applications
- Historical and Environmental Studies
Azienda di Rilievo Nazionale ed Alta Specializzazione
2016-2023
University of Palermo
2016
Abstract In breast cancer (BC) care, radiotherapy is considered an efficient treatment, prescribed both for controlling localized tumors or as a therapeutic option in case of inoperable, incompletely resected recurrent tumors. However, approximately 90% BC-related deaths are due to the metastatic tumor progression. Then, it strongly desirable improve radiosensitivity using molecules with synergistic action. The main aim this study develop curcumin-loaded solid nanoparticles (Cur-SLN) order...
Purpose To investigate the performance of various algorithms for deformable image registration (DIR) to propagate regions interest (ROIs) using multiple commercial platforms. Methods and materials Thirteen institutions participated in study with six platforms: RayStation (RaySearch Laboratories, Stockholm, Sweden), MIM (Cleveland, OH, USA), VelocityAI Smart Adapt (Varian Medical Systems, Palo Alto, CA, Mirada XD (Mirada Ltd, Oxford, UK), ABAS (Elekta AB, Sweden). The DIR were tested on...
Radiation modifiers are largely studied for their contribution to enlarging the treatment window. Curcumin is already known its antioxidant properties; however, role as a radioprotector in preclinical studies affected by well-known low absorption and bioavailability of curcumin. In this study, curcumin's radioprotection ability has been evaluated zebrafish larvae, taking advantage quantifying curcumin evaluating fluorescence transparent embryos. A range 1-10 μM was tested select non-toxic...
This work describes the preliminary analysis of Fricke gels dosimeters characterized by a new formulation making use matrix polyvinyl alcohol cross-linked adding glutaraldehyde and analyzed means nuclear magnetic resonance relaxometry. In previous optical studies, these have shown promising dosimetric features in terms photon sensitivity low diffusion ferric ions produced after irradiation. this work, we used portable relaxometer to measure relaxation times (which are important for...
Objective: To report preliminary findings of a phase II study exploring the clinical outcomes moderate hypofractionated radiotherapy performed with helical tomotherapy (HT) using computed tomography–magnetic resonance imaging–based planning for localized prostate cancer. Methods: The prospective received ethics approval from our institutional committee. A dose 60 Gy/20 fractions low–intermediate risk cancer by means HT was explored. Primary endpoints were acute and late gastrointestinal (GI)...
Cancer heterogeneity represents the main issue for defining an effective treatment in clinical practice, and scientific community is progressively moving towards development of more personalized therapeutic regimens. Radiotherapy (RT) remains a fundamental used many neoplastic diseases, including breast cancer (BC), where high variability at molecular level known. The aim this work to apply generalized linear quadratic (LQ) model customize radiant plan BC, by extracting some characteristic...
It is established that human movements in the vicinity of a permanent static magnetic field, such as those resonance imaging (MRI) scanners induce electric fields body; this raises potential severe risks health to radiographers and cleaners exposed routinely these MRI rooms. The relevant directives parameters, however, are based on theoretical models, accurate studies simulation effects movement data obtained real conditions still lacking. Two one cleaner, familiar with room activities...
Background: The present study reports on the outcomes of our mono-institutional experience Helical Tomotherapy (HT)-based SRT for brain metastases. use this linac is less frequently reported kind treatment. Methods: This retrospective displays a series patients treated with HT-SRT. eligibility using metastases was defined by Karnofsky performance status >70, life expectancy >6 months, and controlled extra-cranial disease; no allowed in case number larger than 10. All cases were discussed...
Abstract Improving safety standards in advanced radiotherapy technologies, where historical experience is not sufficient due to innovation aspects, raises the need perform studies using new tools that follow a holistic view of process chain. Such are useful identify additional critical elements compared analyses carried out by classic tools. In this field, SAPERO (La SicurezzA del PazientE: tecniche avanzate ed innovative per la valutazione rischio di eventi indesiderati all'interno percorso...
To evaluate long-term late side effects, clinical and biochemical relapse in non-metastatic prostate cancer patients treated with dose escalation, from 74 to 78 Gy, by means of three dimensional conformal radiation therapy.Clinical data 125 who underwent three-dimensional therapy were retrospectively evaluated. All stratified, according the NCCN classification, low, intermediate high risk, all them showed histologically proven adenocarcinoma stage T1-T3 at least 2 years follow-up. Late...
To evaluate long-term late side effects, clinical and biochemical relapse in non-metastatic prostate cancer patients treated with dose escalation, from 74 to 78 Gy, by means of three dimensional conformal radiation therapy.Clinical data 125 who underwent three-dimensional therapy were retrospectively evaluated. All stratified, according the NCCN classification, low, intermediate high risk, all them showed histologically proven adenocarcinoma stage T1-T3 at least 2 years follow-up. Late...
Conclusion:The alpha version of the tool is a first step towards its implementation in clinical practice.The will be tested further by patients, to investigate whether it (a) influences quality decision; (b) can used without support.The available Dutch, English and Italian.Future efforts include development decision tools for other primary tumors.