A5063387341- Global Cancer Incidence and Screening
- AI in cancer detection
- Digital Radiography and Breast Imaging
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Lung Cancer Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Breast Lesions and Carcinomas
- Colorectal Cancer Screening and Detection
- MRI in cancer diagnosis
- COVID-19 and healthcare impacts
- Radiology practices and education
- Cancer Risks and Factors
- Traumatic Brain Injury and Neurovascular Disturbances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging Techniques and Applications
- Statistical Methods and Bayesian Inference
- Statistical Methods and Inference
- Cardiac Imaging and Diagnostics
- Cardiovascular and Diving-Related Complications
- Metastasis and carcinoma case studies
- Ultrasound in Clinical Applications
- Medical Imaging and Analysis
- Opioid Use Disorder Treatment
- Spine and Intervertebral Disc Pathology
Harvard University
2019-2024
Massachusetts General Hospital
2018-2024
Mass General Brigham
2022-2024
Office of Science
2022-2024
KBR (United States)
2022
Wyle (United States)
2020
Vanderbilt University Medical Center
2017-2019
Center for Assessment
2018-2019
IMPORTANCEDeaths due to opioid overdose have tripled in the last decade.Efforts curb this trend focused on restricting prescription supply; however, near-term effects of such efforts are unknown.OBJECTIVE To project interventions lower misuse deaths from 2016 2025.DESIGN, SETTING, AND PARTICIPANTS This system dynamics (mathematical) model US epidemic projected outcomes simulated individuals who engage nonmedical or illicit use 2025.The analysis was performed 2018 by retrospectively...
The United States Preventive Services Task Force (USPSTF) recommends low-dose computed tomography screening for lung cancer. However, USPSTF guidelines were derived from a study population including only 4% African American smokers, and racial differences in smoking patterns not considered.To evaluate the diagnostic accuracy of cancer eligibility criteria predominantly low-income cohort.The Southern Community Cohort Study prospectively enrolled adults visiting community health centers across...
Background Screening breast MRI is recommended for women with BRCA mutation or a history of chest radiation, but guidelines are equivocal screening personal cancer high-risk lesion. Purpose To evaluate performance across different elevated risk indications. Materials and Methods All examinations performed between 2011 2014 underwent retrospective medical record review. Indications were as follows: carrier radiation (BRCA/RT group), family (FH (PH lesion (HRL group). metrics calculated...
SUMMARY Missing data are a common problem for both the construction and implementation of prediction algorithm. Pattern submodels (PS)—a set every missing pattern that fit using only from pattern—are computationally efficient remedy handling at stages. Here, we show PS (i) retain their predictive accuracy even when mechanism is not random (MAR) (ii) yield an algorithm most among all standard strategies. Specifically, expected loss forecasting minimized each pattern-specific minimized....
Importance Early detection of pneumothorax, most often via chest radiography, can help determine need for emergent clinical intervention. The ability to accurately detect and rapidly triage pneumothorax with an artificial intelligence (AI) model could assist earlier identification improve care. Objective To compare the accuracy AI vs consensus thoracic radiologist interpretations in detecting any (incorporating both nontension tension pneumothorax) pneumothorax. Design, Setting, Participants...
Deep learning breast cancer risk models demonstrate improved accuracy compared with traditional but have not been prospectively tested. We the of a deep score derived from patient's prior mammogram to scores identify patients in cohort due for screening.We collected data on 119 139 bilateral screening mammograms 57 617 consecutive screened at 5 facilities between September 18, 2017, and February 1, 2021. Patient demographics were retrieved electronic medical records, outcomes determined...
Background: The 2022 Society of Radiologists in Ultrasound (SRU) consensus conference recommendations support less-aggressive management small gallbladder polyps on ultrasound versus earlier approaches and may help standardize polyp evaluation by radiologists.
Background: Thrombosis of the left internal jugular vein in an astronaut aboard International Space Station was recently described, incidentally discovered during a research study blood flow neck veins microgravity. Given this event, and high incidence abnormalities, National Aeronautics Administration (NASA) instituted occupational surveillance program to evaluate astronauts for venous thrombosis. Methods: Duplex ultrasound bilateral conducted on all NASA terrestrially, at three points...
Clinicians rely heavily on fluorodeoxyglucose F18-labeled positron emission tomography (FDG-PET) imaging to evaluate lung nodules suspicious for cancer. We evaluated the performance of FDG-PET diagnosis malignancy in differing populations with varying cancer prevalence.To determine FDG-PET/computed (CT) diagnosing across different prevalence.Multicenter retrospective cohort study at 6 academic medical centers and 1 Veterans Affairs facility that comprised a total 1188 patients known or...
Background Performance metrics with digital breast tomosynthesis (DBT) are based on early experiences. There is limited research whether the benefits of DBT sustained. Purpose To determine improved screening performance sustained over time at population level and after first round individual level. Materials Methods A retrospective review was conducted mammograms that had been obtained before implementation (March 2008 to February 2011, two-dimensional mammography [DM] group) for 5 years...
Background Among breast cancer survivors, detecting a when it is asymptomatic (rather than symptomatic) improves survival; thus, imaging surveillance in these patients warranted. Digital tomosynthesis (DBT) used for screening, but data on DBT this high-risk population are limited. Purpose To determine whether leads to improved screening performance metrics compared with two-dimensional digital mammography among survivors. Materials and Methods In study, mammograms obtained survivors before...
Background Intracranial hemorrhage is a critical finding on computed tomography (CT) of the head. This study compared accuracy an artificial intelligence (AI) model (Annalise Enterprise CTB Triage Trauma) to consensus neuroradiologist interpretations in detecting 4 subtypes: acute subdural/epidural hematoma, subarachnoid hemorrhage, intra‐axial and intraventricular hemorrhage. Methods A retrospective stand‐alone performance assessment was conducted data sets cases noncontrast CT head...
To investigate the impact of thoracic body composition on outcomes after lobectomy for lung cancer.Preoperative identification patients at risk adverse permits treatment modification. The resection has not been investigated in a multicenter setting.A total 958 consecutive undergoing cancer 3 centers from 2014 to 2017 were retrospectively analyzed. Muscle and adipose tissue cross-sectional area fifth, eighth, tenth vertebral was quantified. Prospectively collected national database abstracted...
Abstract Background Accurate diagnosis of idiopathic pulmonary fibrosis (IPF) is essential to inform prognosis and treatment. In 2018, the ATS/ERS/JRS/ALAT Fleischner Society released new diagnostic guidelines for usual interstitial pneumonitis (UIP)/IPF, adding Probable UIP as a CT category based on prior studies demonstrating this had relatively high positive predictive value (PPV) histopathologic UIP/Probable UIP. This study applies 2018 determine test characteristics categories in...
Screening mammography facilities closed during the COVID-19 pandemic in spring 2020. Recovery of screening volumes has varied across patient subgroups and facilities.
Abstract Objective The purpose of this study was to build machine learning models predict surgical upstaging risk ductal carcinoma in situ (DCIS) invasive cancer and compare model performance eligibility criteria used by the Comparison Operative versus Monitoring Endocrine Therapy (COMET) active surveillance trial. Methods Medical records were retrospectively reviewed all women with DCIS at core-needle biopsy who underwent surgery from 2007 2016 an academic medical center. Multivariable...
The purpose of this study is to evaluate the effect background parenchymal enhancement (BPE) on breast cancer risk across different high-risk patient populations undergoing screening MRI.Consecutive MRI examinations performed between 2011 and 2014 were reviewed. Multivariate logistic regression using generalized estimating equations was used assess association following variables with risk: age, qualitative BPE prospective clinical assessment (minimal or mild vs moderate marked),...
Background Although breast cancer incidence and mortality rates increase with advancing age, there are limited data on the benefits risks of screening mammography in older women performance two-dimensional digital (DM) tomosynthesis (DBT) women. Purpose To compare metrics DM DBT among aged 65 years older. Materials Methods For this retrospective study, consecutive mammograms patients from March 2008 to February 2011 (DM group) January 2013 December 2015 (DBT were reviewed. Cancer detection...