A5110573233- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- BRCA gene mutations in cancer
- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Lymphoma Diagnosis and Treatment
- Advanced Breast Cancer Therapies
- Genetic factors in colorectal cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lung Cancer Research Studies
- Genetics and Neurodevelopmental Disorders
- Cerebral Palsy and Movement Disorders
- Dupuytren's Contracture and Treatments
- Global Cancer Incidence and Screening
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- 14-3-3 protein interactions
- Estrogen and related hormone effects
- Spondyloarthritis Studies and Treatments
- Pancreatic function and diabetes
- Research on Leishmaniasis Studies
- Hedgehog Signaling Pathway Studies
Sarah Cannon
2020-2025
Midlands Partnership NHS Foundation Trust
2025
Vanderbilt University Medical Center
2017-2019
Vanderbilt University
2017
SuperGen (United States)
2008-2009
Abstract Background Tumor mutation burden (TMB), a biomarker for immune checkpoint inhibitor (CPI) response, is reported by both blood- and tissue-based next-generation sequencing (NGS) vendors. However, the agreement between TMB from blood (bTMB) tissue (tTMB) in real-world settings, absolute value association with CPI not known. Materials Methods This study utilizes Sarah Cannon’s precision medicine platform, Genospace, to harmonize clinico-genomic data 17 206 patients cancer NGS results...
ABSTRACT Background Axial spondyloarthritis (axSpA) poses a significant diagnostic challenge to health care professionals, with opportunities for early recognition often being missed in primary care. With musculoskeletal First Contact Practitioners (FCPs) rapidly becoming common place settings, the question is raised as whether FCPs are adequately considering axSpA potential diagnosis. Swift and timely referral antecedents diagnosis better outcomes people suspected axSpA; therefore, it...
11098 Background: Inclusion criteria for participating in oncology clinical trials have grown more complex, often challenging the enrollment process. Our objective was to improve process of identifying and enrolling patients by incorporating personalized medicine assistance into initial patient intake trial selection procedure at a major community-based phase 1 unit. Methods: A virtual review board (vPMRB) comprised two PhD scientists reviewed suitable options based on molecular sequencing...
PURPOSE Molecular biomarkers informing disease diagnosis, prognosis, and treatment decisions in patients with breast cancer are being uncovered by next-generation sequencing (NGS) technologies. In this study, we survey how NGS is used for real-world settings a focus on physician behaviors results. METHODS We conducted retrospective analysis of who received testing from commercial vendors as part standard care 2014 to 2019. A total 2,635 reports 2,316 unique were assessed. Hormone receptor...
Islet transplantation has become a well-established therapy for select patients with type 1 diabetes. Viability and engraftment can be compromised by the generation of oxidative stress encountered during isolation culture. We evaluated whether administration BMX-001 (MnTnBuOE-2-PyP5+ [Mn(III) meso-tetrakis-(N-b-butoxyethylpyridinium-2-yl)porphyrin]) its earlier derivative, BMX-010 (MnTE-2-PyP meso-tetrakis-(N-methylpyridinium-2-yl)porphyrin]) could improve islet function outcomes. Long-term...
Identifying genetic variants with pleiotropic associations across multiple cancers can reveal shared biologic pathways. Prior studies have primarily focused on European-descent individuals. Yet population-specific variation occur, and potential among diverse racial/ethnic populations could be missed. We examined cross-cancer lung cancer risk in African Americans.
Globally, lung cancer results in more deaths worldwide than any other cancer, indicating a need for better treatments. Members of the eicosanoid metabolism pathway represent promising therapeutic targets, as several enzymes involved generation these lipids are dysregulated many cancers and their inhibition reduces growth mouse models. However, genetic variation has not been adequately examined association with cancer. The goal this study was to determine whether germline altering producing...
Abstract Background: African Americans have the highest lung cancer mortality in United States. Genome-wide association studies (GWASs) of germline variants influencing survival not yet been conducted with Americans. We examined five previously reported GWAS catalog and explored additional genome-wide associations among American cases. Methods: Incident non–small cell cases (N = 286) Southern Community Cohort Study were genotyped on Illumina HumanExome BeadChip. used Cox proportional hazards...
9613 Background: MET is a validated oncogene for molecular targeted therapy in non-small-cell lung cancer (NSCLC), and METex14 mutations result overexpression. Studies with MET-targeting therapies have demonstrated high objective response rates prolonged disease control. There are few clinical genomic analyses of patients METex14-positive NSCLC the community setting. We herein characterize key findings harboring mutations. Methods: Sarah Cannon provides research to partnering medical...
2540 Background: Tumor mutational burden (TMB) detected by tissue-based Next Generation Sequencing (NGS) is a biomarker for immunotherapy (IO) response. Plasma-based NGS vendors have developed methods quantifying TMB from circulating tumor DNA; however, the concordance of blood-TMB (bTMB) and tissue-TMB (tTMB) in real-world settings has not been examined. In this study, we analyzed paired bTMB-tTMB values cancer patients community oncology clinics who underwent both plasma- testing to...
738 Background: Pancreatic ductal adenocarcinoma (PDAC) remains a devastating diagnosis with an overall 5-year survival rate of ~10%. Therapies targeting KRAS G12D, prevalent molecular driver PDAC, represent active area investigation many agents currently in clinical development. This study characterizes the real-world clinico-genomic landscape patients G12D-mutated PDAC to inform ongoing therapeutic development and trial design. Methods: We conducted retrospective, records-based analysis...
3146 Background: With the 2018 FDA approval of osimertinib for first-line treatment in EGFR-mutated lung cancers, prevalence acquired EGFR T790M mutations is expected to decrease, heightening significance de novo mutations. Previous studies have reported a wide range prevalence, and smaller retrospective indicated that germline may comprise majority Here, we assess frequency community-based setting report on occurring within this population. Methods: Patients with T790M-positive cancer were...
Abstract Activation of JAK2, an intracellular protein tyrosine kinase, is known to induce cell proliferation and apoptosis it has been shown be mediated by pro-inflammatory cytokines. JAK2 dysregulation implicated in myeloproliferative disorders, solid tumor malignancies, autoimmune diseases. Utilizing our proprietary CLIMB™ technology, a computationally driven drug discovery process, we have rapidly designed developed, SGI-1252, potent oral inhibitor which exhibits low nanomolar vitro...
ABSTRACT Background Identifying genetic variants with pleiotropic associations across multiple cancers can reveal shared biologic pathways. Prior studies have primarily focused on European descent individuals. Yet population-specific variation occur and potential among diverse racial/ethnic populations could be missed. We examined cross-cancer lung cancer risk in African Americans. Methods conducted a analysis 1,410 American cases 2,843 controls. 36,958 previously associated (or linkage...
<div>Abstract<p><b>Background:</b> African Americans have the highest lung cancer mortality in United States. Genome-wide association studies (GWASs) of germline variants influencing survival not yet been conducted with Americans. We examined five previously reported GWAS catalog and explored additional genome-wide associations among American cases.</p><p><b>Methods:</b> Incident non–small cell cases (<i>N</i> = 286) Southern...
<div>Abstract<p><b>Background:</b> African Americans have the highest lung cancer mortality in United States. Genome-wide association studies (GWASs) of germline variants influencing survival not yet been conducted with Americans. We examined five previously reported GWAS catalog and explored additional genome-wide associations among American cases.</p><p><b>Methods:</b> Incident non–small cell cases (<i>N</i> = 286) Southern...
Abstract Epithelial and endothelial tyrosine kinase (Etk) is a nonreceptor that plays central role in the proliferation, differentiation, apoptosis, tumorigenicity of epithelial cells. Inhibition Etk signaling can result impaired cellular transformation, down-regulation angiogenesis, increased apoptosis. Employing our proprietary CLIMB™ technology, computationally driven drug discovery process, we designed synthesized approximately 35 small molecules for ETK-inhibition testing biochemical...
Abstract SGI-110 is a second generation hypomethylating agent being developed for treatment in myelodysplastic syndrome (MDS) and solid tumor malignancies. In previous work, has demonstrated potent vivo activity number of types, including non-hematological cell lines. Current efforts are underway to optimize formulation delivery first-in-human (FIH) studies. animals, well-tolerated across multiple species utilizing routes drug delivery. Tolerability studies have been performed mouse, rat,...