A5074065367- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Advanced Chemical Sensor Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Analytical Chemistry and Sensors
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Analytical chemistry methods development
- Chemical Synthesis and Analysis
- Dendrimers and Hyperbranched Polymers
- Thermal and Kinetic Analysis
- Polymer crystallization and properties
- Polymer Nanocomposites and Properties
- Metabolomics and Mass Spectrometry Studies
- Chromatography in Natural Products
- Biosimilars and Bioanalytical Methods
- Advanced Polymer Synthesis and Characterization
- Axial and Atropisomeric Chirality Synthesis
- Advancements in Photolithography Techniques
- Luminescence and Fluorescent Materials
- Innovative Microfluidic and Catalytic Techniques Innovation
- Ferrocene Chemistry and Applications
- Photopolymerization techniques and applications
- Blood properties and coagulation
- Ion-surface interactions and analysis
Brightlands Materials Center
2025
DSM (Netherlands)
2010-2023
Ion mobility (IM) is now a well-established and fast analytical technique. The IM hardware constantly being improved, especially in terms of the resolving power. Drift Tube (DTIMS), Traveling Wave (TWIMS), Trapped Mobility Spectrometry (TIMS) coupled to mass spectrometry are used determine Collision Cross-Sections (CCS) ions. In chemistry, CCS approached as descriptor for ion identification it also physical chemistry 3D structure elucidation with computational support. extracted from reduced...
Recent developments in the field of ion mobility spectrometry provide new possibilities to explore and understand gas-phase chemistry. In this study, hyphenated trapped spectrometry-mass (TIMS-MS) was applied investigate analyte as function adduct formation for twelve pharmaceutically relevant molecules, tetrahydrocannabinol (THC) its isomer cannabidiol (CBD). Samples were introduced by direct infusion ions generated with positive electrospray ionization (ESI+) observing protonated sodiated...
Over the years, polymer analyses using ion mobility-mass spectrometry (IM-MS) measurements have been performed on different mobility (IMS) setups. In order to be able compare literature data taken IM(-MS) instruments, heating and temperature evaluations already explored. Nevertheless, extrapolations other analytes are difficult thus straightforward same-sample instrument comparisons seem only reliable way make sure that setups do not greatly change gas-phase behavior. We used a large range...
Background: DBS cards have been a big promise for decades. However, blood with low hematocrit (Ht) values results on regular cellulose-based in larger spot sizes, compared high Ht-values. A new material has developed to solve this problem. Results: This material, based hydrophilic-coated woven polyester fibers, shows sizes independent of the Ht-value blood. Homogeneity over is within 10% RSD. Conclusion: Quantitative measurements broad Ht range show nonbiased whole analysis. The are...
Abstract Both the Michael addition and hydrogenation steps in large scale synthesis of polypropylenimine dendrimers have been improved: by adding ammonia during hydrogenations substrate concentrations can be increased 8 times, catalyst concentration lowered 10 times average selectivity remains > 99.5% per conversion. The dimensions studied with SANS molecular calculations.
Rationale The separation of isomeric compounds with major differences in their physiochemical and pharmacokinetic properties is particular importance pharmaceutical R&D. However, the structural assessment these current analytical techniques methods are still a challenge. In this study, we describe strategies to separate various stereo‐isomers. Methods ten stereo‐isomers was investigated using Trapped Travelling Wave ion mobility spectrometry (TIMS TWIMS). Different including adduct...
Isomeric separation of prostanoids is often a challenge and requires chromatography time-consuming sample preparation. Multiple prostanoid isomers have distinct in vivo functions crucial for understanding the inflammation process, including prostaglandins E2 (PGE2 ) D2 (PGD2 ). High-resolution ion mobility spectrometry (IMS) based on linear transport low-to-moderate electric fields nonlinear strong emerges as broad approach rapid separations prior to mass spectrometry.Derivatization with...
Melt-mixing of blends polyamide 46 (PA 46) and 6I 6I) gives rise to the formation copolymers on account occurrence transamidation reactions. The degree as obtained during first minutes melt-mixing is often too low permit characterization by NMR or FTIR. To solve this problem, gradient elution chromatography (GEC) has been used. It visualized using technique what extent occurring 10 min melt-mixing. Also, dependence reaction rate extrusion temperature studied GEC. Melt-blending PA having...
In this study, we evaluate the use of various two-dimensional liquid chromatographic methods to characterize water-soluble, synthetically grafted bio-polymers, consisting long poly(acrylic acid) chains and short maltodextrin grafts. The confirmation presence grafting estimation its extent is challenging. It complicated by limited solubility polymers, their structural dispersity chemical heterogeneity. Moreover, starting materials (and other reagents, reaction products additives) may be...
Abstract A new method to determine the blockiness and especially block length distribution (BLD) of copolymers is described. This Systematic Workflow Analyze Multi‐fragmented Polymers with Mass Spectrometry (SWAMP‐MS) developed characterize sequence synthetic polymers. Copolymerization polyamide 4,6 4,10 used as a model system. Supercharged polymer ions, generated by electrospray ionization, swamp mass spectrum due <1> different chemical related distributions (chain composition, end...