A5021306641- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Advanced Polymer Synthesis and Characterization
- Microfluidic and Capillary Electrophoresis Applications
- biodegradable polymer synthesis and properties
- Polymer crystallization and properties
- Advanced Chemical Sensor Technologies
- Chromatography in Natural Products
- Polymer Nanocomposites and Properties
- Protein purification and stability
- Analytical Chemistry and Sensors
- Microplastics and Plastic Pollution
- Polymer composites and self-healing
- Electron Spin Resonance Studies
- Arsenic contamination and mitigation
- Thermal and Kinetic Analysis
- Metabolomics and Mass Spectrometry Studies
- Enzyme Catalysis and Immobilization
- Cancer Treatment and Pharmacology
- Chemotherapy-induced cardiotoxicity and mitigation
- Photopolymerization techniques and applications
- Silicone and Siloxane Chemistry
- Synthesis and properties of polymers
- Force Microscopy Techniques and Applications
- Biopolymer Synthesis and Applications
University of Amsterdam
2016-2025
Covestro (Germany)
2024-2025
Covestro (Japan)
2023-2024
Medisch Centrum Haaglanden
2021-2024
Art Innovation (Netherlands)
2024
DSM (Netherlands)
2011-2021
The University of Texas Health Science Center at Houston
2016
Altrecht GGZ
2011
University Medical Center Utrecht
2011
Eindhoven University of Technology
2008
Polymeric nanoparticles have become indispensable in modern society with a wide array of applications ranging from waterborne coatings to drug-carrier-delivery systems. While large range techniques exist determine multitude properties these particles, relating physicochemical the particle chemical structure intrinsic polymers is still challenging. A novel, highly orthogonal separation system based on comprehensive two-dimensional liquid chromatography (LC × LC) has been developed. The...
Abstract The results of three experimental studies, i.e. GC‐MS peroxide‐cross‐linked alkene/alkane mixtures, 13 C NMR peroxide‐cured, C‐labeled 2‐ethylidene‐5‐norbornene ‐ ethylene‐propylene‐diene‐monomer (EPDM) and EPR peroxide curing EPDM, are combined, yielding a more accurate description the mechanism cure EPDM. Both alkyl allyl macro‐radicals formed via H‐abstraction from EPM main chain residual diene unsaturation, respectively. Combination these yields alkyl/alkyl, alkyl/allyl...
Polyesters obtained by the catalytic ring-opening polymerization of macrolactones in many aspects resemble properties polyethylene. However, molecular weight distribution is intrinsically different and equals observed for a step-growth process even though macrolactone follows chain-growth mechanism. The concurrent occurrence transesterification reactions leading to formation cyclic polymers responsible deviation from characteristic polymerization. To explain extent on theoretical principles...
A range of poly(ethylene glycol) (PEG)-based polyacrylate networks with two different topological properties were synthesized by photoinitiated free-radical polymerization and analyzed mechanical, chromatographic, NMR methods. Comparison between ziplike pointlike junctions pinpointed the critical role network topology in generating so-called "short chain abnormality" polymer dynamics. In particular, double quantum (DQ) analysis identified strong constraints on isotropic movement chains...
A fast algorithm for automated feature mining of synthetic (industrial) homopolymers or perfectly alternating copolymers was developed. Comprehensive two-dimensional liquid chromatography-mass spectrometry data (LC × LC-MS) utilized, undergoing four distinct parts within the algorithm. Initially, is reduced by selecting regions interest data. Then, all are clustered on time and mass-to-charge domain to obtain isotopic distributions. Afterward, single-value clusters background signals removed...
An understanding of the composition and molecular heterogeneities complex industrial polymers forms basis gaining control physical properties materials. In current work we report on development an online method to hyphenate liquid polymer chromatography with pyrolysis-GC (Py-GC). The designed workflow included a 10-port valve for fractionation first-dimension effluent. Collected fractions were transferred Py-GC by means second LC pump, 6-port was used injection in Py-GC, allowing pump...
The characterization of the microstructure in vivo degradable polyesters is gaining increased interest thanks to their high-performance applications, such as drug delivery systems. design material requires a high level understanding critical attributes polyesters, molecular-weight distribution (MWD), chemical-composition (CCD), and end-groups (functionality-type distribution, FTD). Size-exclusion chromatography (SEC) hyphenated with mass spectrometry (MS) yields SEC-MS, which an effective...
The performance, biodegradability, and recyclability of polymers can be tuned during synthesis by adopting monomers with different chemical characteristics. Recent research has shown the aptness some hydrolases to depolymerize polyesters under mild conditions compared approaches. Herein, we engineered a cutinase from Thermobifida cellulosilytica (Tc_Cut2NVWCCG) for improved thermostability (up 91 °C) it previously reported leaf‐branch compost (LCCWCCG) hydrolysis low molar mass substrates,...
The characterization of the microstructure in vivo degradable polyesters is gaining increased interest thanks to their high-performance applications, such as drug delivery systems. design material requires a high level understanding critical attributes polyesters, molecular-weight distribution (MWD), chemical-composition (CCD), and end-groups (functionality-type distribution, FTD). Size-exclusion chromatography (SEC) hyphenated with mass spectrometry (MS) an effective method for analyzing...
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTInsights into the Initiation Process of Enzymatic Ring-Opening Polymerization from Monofunctional Alcohols Using Liquid Chromatography under Critical ConditionsMatthijs de Geus†, Ron Peters‡, Cor E. Koning†, and Andreas Heise*†‡View Author Information Department Polymer Chemistry, Technische Universiteit Eindhoven, Den Dolech 2, P.O. Box 513, 5600 MB The Netherlands, DSM Research, 18, 6160 MD Geleen, Netherlands* Corresponding author. Email: [email...
The chain sequence of co-polymers strongly affects their physical properties. It is, therefore, crucial importance for the development and final properties novel materials. Currently however, few analytical methods are available to monitor copolymers. currently preferred method in copolymer-sequence determination, nuclear-magnetic-resonance spectroscopy (NMR), is insensitive (especially when 13C-NMR required) often offers little spectral resolution between signals indicative different...
Block copolymers composed of methacrylic acid (MAA) and methyl methacrylate (MMA) blocks are interesting candidates for replacing surfactants in emulsion polymerization methods. Here the synthesis experimental characterization well-defined PMAA–PMMA block made via RAFT reported. It is shown that these self-organize water into micellar spherical or cylindrical structures highly size disperse (probably vesicles) aqueous salt solutions upon increasing pH. The physical properties polymer...
Smokeless powders (SPs) are one of the most commonly used propellants for ammunition but can also be abused as energetic material in improvised explosive devices (IEDs) such pipe bombs. After a shooting or explosion, unburnt partially burnt particulates may observed which forensic investigation. SPs comprise mainly nitrocellulose (NC) and additives. Therefore, characterization both NC additives is significant importance. Typically, identification, classification, chemical profiling smokeless...