A5039941652- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Cancer Treatment and Pharmacology
- Reproductive Health and Technologies
- Ectopic Pregnancy Diagnosis and Management
- Chemotherapy-induced cardiotoxicity and mitigation
- Heavy Metal Exposure and Toxicity
- Reproductive Health and Contraception
- Effects and risks of endocrine disrupting chemicals
- Breast Cancer Treatment Studies
- Gynecological conditions and treatments
- Pregnancy and Medication Impact
- Colorectal Cancer Treatments and Studies
- Advanced Breast Cancer Therapies
- Adipose Tissue and Metabolism
- Sperm and Testicular Function
- Parvovirus B19 Infection Studies
- Regulation of Appetite and Obesity
- Pregnancy and preeclampsia studies
- HER2/EGFR in Cancer Research
- Cancer Diagnosis and Treatment
Valencian Infertility Institute
2012-2024
Instituto de Investigación Sanitaria La Fe
2021-2024
Digital Research Alliance of Canada
2024
Universitat de València
2008-2020
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019
Research Institute Hospital 12 de Octubre
2019
Hospital Clínic de Barcelona
2019
Institut Curie
2018
Igenomix
2018
INCLIVA Health Research Institute
2015
Does clinical performance of personalized embryo transfer (PET) guided by endometrial receptivity analysis (ERA) differ from frozen (FET) or fresh in infertile patients undergoing IVF?Multicentre, open-label randomized controlled trial; 458 aged 37 years younger IVF with blastocyst at first appointment were to PET ERA, FET 16 reproductive clinics.Clinical outcomes intention-to-treat comparable, but cumulative pregnancy rate was significantly higher the (93.6%) compared (79.7%) (P = 0.0005)...
Abstract STUDY QUESTION Is there a serum progesterone (P) threshold on the day of embryo transfer (ET) in artificial endometrium preparation cycles below which chances ongoing pregnancy are reduced? SUMMARY ANSWER Serum P levels <8.8 ng/ml ET lower rate (OPR) both own or donated oocyte cycles. WHAT IS KNOWN ALREADY We previously found that <9.2 significantly decrease OPR sample 211 donation recipients. Here, we assessed whether these results applicable to all infertile patients...
This descriptive study evaluates the impact on endometrial development of standard and high doses a GnRH antagonist in stimulated cycles compared with agonist natural cycles.Thirty-one oocyte donors were treated combination rFSH 0.25 mg/day ganirelix (standard dose), 2 (high dose) or 0.6 buserelin (long protocol). Vaginal progesterone (200 mg/day) was administered luteal phase. Endometrial biopsies performed 7 days after HCG administration. Additional carried out subset 12 subjects,...
Highly purified hMG (hp-hMG) has recently shown better cycle outcome than the recombinant FSH (rFSH) when compared in GnRH agonist long protocol cycles. However, they have not yet been antagonist cycles.A RCT comparing ongoing pregnancy rate (primary end-point) 280 patients undergoing IVF/ICSI after stimulation with hp-hMG or rFSH controlled a antagonist.No significant differences were observed between and terms of per started (35.0 versus 32.1%, respectively; P = 0.61); relative risk: 1.09...
Abstract STUDY QUESTION Is there a relationship between serum and endometrial progesterone (P4) levels, including P4 metabolites (oestrone, oestradiol 17α-hydroxyprogesterone), receptivity? SUMMARY ANSWER Serum levels were not correlated with P4, nor associated receptivity as determined by the ERA® test; however, 17α-hydroxyprogesterone positively related to ERA. WHAT IS KNOWN ALREADY Acquisition of is governed which induces secretory transformation. A close pregnancy outcome reported for...
Abstract Background Women with adenomyosis are characterized by having defective decidualization, impaired endometrial receptivity and/or embryo-maternal communication, and implantation failure. However, the molecular mechanisms underlying adenomyosis-related infertility remain unknown, mainly because of restricted accessibility difficult preservation tissue in vitro. We have recently shown that patient-derived organoids, maintain disease-specific features while differentiated into...
How did coronavirus disease 2019 (COVID-19) impact on medically assisted reproduction (MAR) services in Europe during the COVID-19 pandemic (March to May 2020)?MAR services, and hence treatments for infertile couples, were stopped most European countries a mean of 7 weeks.With outbreak Europe, non-urgent medical care was reduced by local authorities preserve health resources maintain social distancing. Furthermore, ESHRE other societies recommended postpone ART pregnancies as 14 March 2020.A...
In order to investigate whether gonadotrophin-releasing hormone (GnRH) antagonists exert a significant effect on steroid secretion in vivo compared with GnRH agonists, concentrations of sex hormones (oestradiol, progesterone and testosterone) were studied follicular fluid from women undergoing ovarian stimulation treated either agonist or antagonist. addition, the correlation between variables oocyte development was evaluated.Microparticle enzyme immunoassay radioimmunoassays used.The mean...
What are the key considerations for developing an enhanced transcriptomic method secretory endometrial tissue dating?
Essential trace elements are micronutrients whose deficiency has been associated with altered fertility and/or adverse pregnancy outcomes, while surplus may be toxic. The concentrations of eight essential were measured using inductively coupled mass spectrometry (ICP-MS) and assessed respect to clinical in vitro fertilization (IVF) outcomes a population 51 women undergoing IVF intracytoplasmic sperm injection (ICSI), pre-implantation genetic screening for aneuploidy (PGT-A), single frozen...
Adenomyosis is related to infertility and miscarriages, but so far there are no robust in vitro models that reproduce its pathological features study the molecular mechanisms involved this disease. Endometrial organoids 3D recapitulate native microenvironment tissue characteristics would allow of adenomyosis pathogenesis disorders. In our study, human endometrial biopsies from (n = 6) healthy women were recruited. Organoids established hormonally differentiated midsecretory gestational...
The GnRH analogue (agonist and antagonist GnRH) changed ovarian stimulation. On the one hand, it improved chances of pregnancy to obtain more oocytes better embryos. This leads an hyper-response, which can be complicated by hyperstimulation syndrome (OHSS). other prevent incidence OHSS: protocols, agonist for triggering final oocyte maturation, either together or separately, coasting, may prove useful avoiding OHSS in high-risk patients. We review these topics this article.
Poor ovarian response (POR) patients often face the risk of not having enough competent oocytes. Then, aspirating small follicles could serve as a strategy to increase their number. Many efforts have been addressed associate follicular size with oocyte competence, but results are controversial. Therefore, our study aimed evaluate maturation and developmental along non-invasive oocyte-maturation-related miRNA signature in oocytes retrieved from both large follicles. A total 178 follicles, 31...