A5027671578- Reproductive Biology and Fertility
- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Ovarian function and disorders
- Sperm and Testicular Function
- Renal and related cancers
- Reproductive System and Pregnancy
- Pluripotent Stem Cells Research
- Endometriosis Research and Treatment
- Ectopic Pregnancy Diagnosis and Management
- Mitochondrial Function and Pathology
- Gynecological conditions and treatments
- Pregnancy and preeclampsia studies
- Molecular Biology Techniques and Applications
- Metabolism and Genetic Disorders
- Reproductive Physiology in Livestock
- Extracellular vesicles in disease
- Chromosomal and Genetic Variations
- Pregnancy and Medication Impact
- Birth, Development, and Health
- Carcinogens and Genotoxicity Assessment
- Cell death mechanisms and regulation
- Hemostasis and retained surgical items
- Wound Healing and Treatments
Valencian Infertility Institute
2016-2025
Instituto de Investigación Sanitaria La Fe
2019-2025
Universitat de València
2000-2024
Digital Research Alliance of Canada
2024
Instituto Valenciano de Competitividad Empresarial
2021
INCLIVA Health Research Institute
2015-2019
Istituto di Istruzione Superiore I.T.C. Di Vittorio
2019
Igenomix
2011-2018
Guardia Civil
1992-2014
Radboud University Nijmegen
2011
ObjectiveTo assess the outcomes achieved after Cryotop vitrification of both early cleavage and blastocyst-stage embryos to determine whether embryo developmental stage quality as well origin (ovum donation cycles, patients' own oocytes) endometrial preparation for transfer had any effect on final outcome.DesignObservational study.SettingPrivate university-affiliated IVF center.Patient(s)Women undergoing 3,150 warming cycles whose were vitrified due various...
Abstract STUDY QUESTION How should recurrent implantation failure (RIF) in patients undergoing ART be defined and managed? SUMMARY ANSWER This is the first ESHRE good practice recommendations paper providing a definition for RIF together with on how to investigate causes contributing factors, improve chances of pregnancy. WHAT IS KNOWN ALREADY challenge clinic, multitude investigations interventions offered applied clinical practice, often without biological rationale or unequivocal evidence...
In the study reported here, we localized at protein level major components of interleukin (IL)-1 system in human embryo, and investigated endometrial factors influencing their secretion during embryonic development. To localize these components, performed immunohistochemical experiments 44 oocytes 78 embryos. The following primary antibodies were used: monoclonal mouse anti-human IL-1 receptor type I (IL-1R tl), IL-1β, polyclonal rabbit antagonist (IL-1ra). For embryo culture, embryos...
Apico-basal polarization of cells within the embryo is critical for segregation distinct lineages during mammalian development. Polarized become trophectoderm (TE), which forms placenta, and apolar inner cell mass (ICM), founding population fetus. The cellular molecular mechanisms leading to human its timing embryogenesis have remained unknown. Here, we show that occurs in two steps: it begins with apical enrichment F-actin followed by accumulation PAR complex. This two-step process leads...
BACKGROUNDThe use of ovarian stimulation, to stimulate a multi-follicular response for assisted reproduction treatments, may force the production oocytes from follicles that do not reach optimal maturation, possibly yielding are fully competent. The present study aimed define follicular environment and oocyte competence unstimulated pre-ovulatory follicles, compare it with similar-sized stimulated follicles. For this purpose, we analyzed hormonal milieu, meiotic spindle, embryo development...
Sperm vitrification (V) is a method for cryopreservation, without the use of conventional cryoprotectants, by plunging sperm suspension directly into liquid nitrogen (LN25).This study aimed to compare new system V with freezing (CF) protocol using fresh spermatozoa as reference (C).Prospective cohort study. A total 47 samples from men attending infertility clinic at Instituto Valenciano de Infertilidad Valencia. The solution was 0.3 M trehalose-sucrose and plunged in microdroplets 5-10 lL,...
Aneuploidy in preimplantation embryos is a major cause of human reproductive failure. Unlike uniformly aneuploid embryos, diagnosed as diploid-aneuploid mosaics after genetic testing for aneuploidy (PGT-A) can develop into healthy infants. However, the reason why these achieve full competence needs further research. Current RNA sequencing techniques allow investigation transcriptome, providing new insights molecular mechanisms embryo development. In this prospective study, using euploid gene...
What is the final hormonal milieu of pre-ovulatory follicles low-responder (LR) patients undergoing unstimulated cycles?Neither androgen secretion nor LH was impaired in LR women.Therapies currently used to improve ovarian response women have an impact on follicular milieu, and these changes are believed be partially responsible for determining success rate women. Surprisingly, as far we know, there no report profile cycles or evidence that impaired.A prospective case-control study including...