A5074101757- Genomics and Phylogenetic Studies
- Gene Regulatory Network Analysis
- Plant Molecular Biology Research
- Plant and animal studies
- Chromosomal and Genetic Variations
- Plant Diversity and Evolution
- Bioinformatics and Genomic Networks
- Plant Reproductive Biology
- Plant and Fungal Species Descriptions
- Modular Robots and Swarm Intelligence
- Gene expression and cancer classification
- Genetic diversity and population structure
- Scientific Computing and Data Management
- RNA and protein synthesis mechanisms
- Evolution and Genetic Dynamics
- Plant Virus Research Studies
- Mycorrhizal Fungi and Plant Interactions
- Photosynthetic Processes and Mechanisms
- Genomics and Chromatin Dynamics
- Genetic Mapping and Diversity in Plants and Animals
- Machine Learning in Bioinformatics
- Complex Systems and Decision Making
- Evolutionary Algorithms and Applications
- Plant Pathogens and Fungal Diseases
- Plant Pathogenic Bacteria Studies
University of Hertfordshire
2020-2024
Royal Botanic Gardens, Kew
2018-2021
The Pirbright Institute
2014-2016
University of East Anglia
2003-2013
University of Lübeck
2003
Max Planck Society
1996-1999
Sequencing of target-enriched libraries is an efficient and cost-effective method for obtaining DNA sequence data from hundreds nuclear loci phylogeny reconstruction. Much the cost developing targeted sequencing approaches associated with generation preliminary needed identification orthologous probe design. In plants, identifying has proven difficult due to a large number whole-genome duplication events, especially in angiosperms (flowering plants). We used multiple alignments over 600 353...
The tree of life is the fundamental biological roadmap for navigating evolution and properties on Earth, yet remains largely unknown. Even angiosperms (flowering plants) are fraught with data gaps, despite their critical role in sustaining terrestrial life. Today, high-throughput sequencing promises to significantly deepen our understanding evolutionary relationships. Here, we describe a comprehensive phylogenomic platform exploring angiosperm life, comprising set open tools based 353...
Angiosperms are the cornerstone of most terrestrial ecosystems and human livelihoods
The evolutionary origin of the angiosperms (flowering plants sensu stricto ) is still enigmatic. Answers to question angiosperm origins are intimately connected identification their sister group among extinct and extant taxa. Most phylogenetic analyses based on morphological data agree that groups seed plants, gnetophytes angiosperms. According this view, only members a clade called “anthophytes” emphasize shared possession flower-like reproductive structures. However, most phylogeny...
Flowers sensu lato are short, specialized axes bearing closely aggregated sporophylls. They typical for seed plants (spermatophytes) and prominent in flowering stricto (angiosperms), where they often comprise an attractive perianth. There is evidence that spermatophytes evolved from gymnosperm-like with a fern-like mode of reproduction called progymnosperms. It seems plausible, therefore, the stamens/carpels pollen sacs/nucelli homologous to fern sporophylls sporangia, respectively. However,...
Abstract Family Cortinariaceae currently includes only one genus, Cortinarius , which is the largest Agaricales with thousands of species worldwide. The are important ectomycorrhizal fungi and form associations many vascular plant genera from tropicals to arctic regions. Genus contains a lot morphological variation, its complexity has led taxonomists specialize in particular on infrageneric groups. previous attempts divide have been shown be unnatural phylogenetic studies done date not able...
Abstract Sequencing of target-enriched libraries is an efficient and cost-effective method for obtaining DNA sequence data from hundreds nuclear loci phylogeny reconstruction. Much the cost associated with developing targeted sequencing approaches preliminary needed identifying orthologous probe design. In plants, has proven difficult due to a large number whole-genome duplication events, especially in angiosperms (flowering plants). We used multiple alignments over 600 353 putatively...
The specification of floral organ identity during development depends on the function a limited number homeotic genes grouped into three classes: A, B, and C. Pairs paralogous B class genes, such as DEF GLO in Antirrhinum, AP3 PI Arabidopsis, are required for establishing petal stamen identity. To gain better understanding evolutionary origin petals stamens, we have looked orthologs conifers. Here report cDNA cloning PrDGL (Pinus radiata DEF/GLO-like gene) from pine. We provide phylogenetic...
Abstract Providing science and society with an integrated, up‐to‐date, high quality, open, reproducible sustainable plant tree of life would be a huge service that is now coming within reach. However, synthesizing the growing body DNA sequence data in public domain disseminating trees to diverse audience are often not straightforward due numerous informatics barriers. While big synthetic phylogenies being built, they remain static become quickly outdated as new published tree‐building...
The appropriate timing of developmental transitions is critical for adapting many crops to their local climatic conditions. Therefore, understanding the genetic basis different aspects phenology could be useful in highlighting mechanisms underpinning adaptation, with implications breeding climate change. For bread wheat (Triticum aestivum), transition from vegetative reproductive growth, start and rate leaf senescence relative stages flowering grain filling all contribute plant performance....
The process by which eukaryotic viruses with segmented genomes select a complete set of genome segments for packaging into progeny virus particles is not understood. In this study model based on the association through specific RNA-RNA interactions driven base pairing was formalized and tested in Orbivirus genus Reoviridae family. A strategy combining screening genomic sequences inter-segment complementarity direct functional testing using reverse genetics described type species genus,...
Full-genome sequences have been used to monitor the fine-scale dynamics of epidemics caused by RNA viruses. However, ability this approach confidently reconstruct transmission trees is limited knowledge genetic diversity viruses that exist within different epidemiological units. In order address question, study investigated variability 45 foot-and-mouth disease virus (FMDV) genome (from 33 animals) were collected during 2007 from eight premises (10 herds) in United Kingdom. Bayesian and...
Experimental identification of microRNA (miRNA) targets is a difficult and time consuming process. As consequence several computational prediction methods have been devised in order to predict for follow up experimental validation. Current target use only the miRNA sequence as input. With an increasing number experimentally validated becoming available, utilising this additional information search further may help improve specificity site prediction.We introduce generic method, Stacking...
Abstract The tree of life is the fundamental biological roadmap for navigating evolution and properties on Earth, yet remains largely unknown. Even angiosperms (flowering plants) are fraught with data gaps, despite their critical role in sustaining terrestrial life. Today, high-throughput sequencing promises to significantly deepen our understanding evolutionary relationships. Here, we describe a comprehensive phylogenomic platform exploring angiosperm life, comprising set open tools based...
Recognition of protein-DNA binding sites in genomic sequences is a crucial step for discovering biological functions sequences. Explosive growth availability sequence information has resulted demand site detection methods with high specificity. The motivation the work presented here to address this by systematic approach based on Maximum Likelihood Estimation. A general framework developed which large class can be described uniform and consistent way. Protein-DNA determined energy, an...