Objective To describe characteristics of vasomotor symptoms, specifically daily frequency and severity, among women 40–65 years old in the United States (US).Design A survey was completed by a nationally representative sample 4402 US aged old. questionnaire focusing on menopausal symptoms administered online April 2005.Results The prevalence 79% peri- 65% postmenopausal women. Women with had an average 2.5 very mild/mild, 2.6 moderate, severe, 1.4 severe daytime hot flushes typical day....

Summary Background Gastrointestinal side effects are commonly associated with opioid treatment for pain. Aim To understand gastrointestinal treatment. Methods This study was a population‐based survey of adults in the US who use opioids to manage pain unrelated cancer. Participants were recruited from an existing Web‐enabled panel and supplemental individuals previously indicated interest participating Web‐based surveys. Results Overall, 2055 participated main phase survey. Fifty‐seven per...

Article AbstractObjective:†‹ Sexual dysfunction is a common side effect of antidepressant treatment, but recognition the problem variable. The aim this stuy was to estimate prevalence and impact sexual during treatment in 2 European countries. Method: A cross-sectional survey 502 adults France United Kingdom. All participants were diagnosed with depression taking selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine (SNRI), starting within previous 3 months. Information...

Objective To identify and explore concepts important to patients with cognitive symptoms of major depressive disorder (MDD) adapt an existing patient-reported outcome (PRO) measure assess these symptoms. Methods Four focus groups were conducted MDD (n = 33) elicit relevant determine whether one several PRO scales could be used depression. Following selection minor modification the Perceived Deficits Questionnaire (PDQ), debriefing interviews additional 17) further refine this for use in MDD....

Article Abstract Objective: Develop a brief, patient-reported screening tool designed to identify individuals with probable binge-eating disorder (BED) for further evaluation or referral specialists. Methods: Items were developed on the basis of DSM-5 diagnostic criteria, existing tools, and input from 3 clinical experts (January 2014). then refined in cognitive debriefing interviews participants self-reporting BED characteristics (March 2014) piloted multisite, cross-sectional, prospective,...

Sexual dysfunction is a common but often unrecognized side effect of many antidepressants. Building upon the results previous investigation, this study aimed to assess prevalence and impact antidepressant-associated sexual (AASD) in three European countries. A cross-sectional survey 704 adults Germany, Spain, The Netherlands was used study. All participants had recently started taking selective serotonin reuptake inhibitor or serotonin— noradrenaline inhibitor. Information about other...

Two experiments examined the role of cognitive inflexibility and reduced working memory in age-related declines on Wisconsin Card Sorting Test. Both standard scoring procedures newly developed scores were used to measure each construct, modifications test further evaluated memory. Results indicated that age differences are not due but for a subset older adults errors associated with reduction amount information can be stored or processed These disappear, however, when visual cues provide...

The Impact of Weight on Quality Life‐Lite (IWQOL‐Lite) is widely used in evaluations weight‐loss interventions, including pharmaceutical trials. Because this measure was developed using input from individuals undergoing intensive residential treatment, the IWQOL‐Lite may include concepts not relevant to clinical trial populations and be missing that are these populations. An alternative version, Clinical Trials Version (IWQOL‐Lite‐CT), validated according US Food Drug Administration's...

In patients with pro-opiomelanocortin (POMC) or leptin receptor (LEPR) deficiency, managing obesity and hyperphagia can be burdensome for caretakers. The impacts on health-related quality of life are under-recognized not well characterized. We conducted in-depth qualitative interviews in POMC (n = 3) LEPR 2) deficiencies participating an ongoing open-label extension phase 3 clinical trials the melanocortin 4 agonist setmelanotide to describe patient experience characterize changes following...

Bardet-Biedl syndrome (BBS) is a rare genetic disease associated with hyperphagia, pathologic insatiable hunger, due to impaired signaling in the melanocortin-4 receptor (MC4R) pathway. The impact of hyperphagia on lives patients BBS and their families has not been fully characterized.Patients or caregivers who participated clinical trials MC4R agonist setmelanotide (NCT03013543 NCT03746522) were included this qualitative study. Telephone interviews conducted using semistructured interview...

The objective of this study was to develop and validate a daily electronic Endometriosis Pain Bleeding Diary (EPBD) for assessing treatment-related changes in endometriosis symptoms from the patient's perspective clinical trial setting. EPBD items were developed based on clinician input results 5 focus groups (N = 38) 3 iterative sets cognitive interviews 22). psychometric properties evaluated using data collected usual-practice, non-intervention conducted at 4 sites United States. Existing...

Summary The Impact of Weight on Daily Activities Questionnaire (IWDAQ) is a patient‐reported outcome measure that uses novel, adaptive design to assess the limitations in daily activities are most important individuals attempting lose weight. During first round completing IWDAQ, respondents presented with 18 everyday can be limited by excess weight and asked choose three they would like see improve loss. They then rate degree limitation experience these at baseline follow‐up assessments....