A5101963190- Marriage and Sexual Relationships
- Enzyme Structure and Function
- Glycosylation and Glycoproteins Research
- Microbial bioremediation and biosurfactants
- Cancer Genomics and Diagnostics
- Chemical Synthesis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Mass Spectrometry Techniques and Applications
- Organizational Learning and Leadership
- Semiconductor materials and devices
- Enzyme Catalysis and Immobilization
- Supramolecular Self-Assembly in Materials
- Career Development and Diversity
- Higher Education and Employability
- Chemical Reaction Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Immune Response and Inflammation
- Molecular Biology Techniques and Applications
- Receptor Mechanisms and Signaling
- Ocular and Laser Science Research
- Education, Achievement, and Giftedness
- Click Chemistry and Applications
- Radiopharmaceutical Chemistry and Applications
- Aquaculture Nutrition and Growth
- Estrogen and related hormone effects
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
Hood College
2021
Frederick Community College
2021
Seventh Sense Biosystems (United States)
2018
University of Michigan
2014-2017
American College of Preventive Medicine
2014-2017
Park University
2014-2015
Princeton Public Schools
2014-2015
The University of Queensland
2012-2013
Human granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine derived from activated T cells, endothelial fibroblasts, and macrophages.It stimulates myeloid erythroid progenitors to form colonies in semisolid medium vitro, as well enhancing multiple differentiated functions of mature neutrophils, macrophages, eosinophils.We have examined the binding human GM-CSF variety responsive cells cell lines.The most myelomonocytic specifically eosinophils, express highest numbers...
Several independent studies of bacterial degradation nitrate ester explosives have demonstrated the involvement flavin-dependent oxidoreductases related to old yellow enzyme (OYE) yeast. Some these enzymes also transform nitroaromatic explosive 2,4,6-trinitrotoluene (TNT). In this work, catalytic capabilities five members OYE family were compared, with a view correlating structure and function. The activity profiles differed substantially; no one compound proved be good substrate for all...
A DSP-based low-power 12.5Gb/s SerDes using a baud-rate ADC and digital data-path is developed for backplane data communication. 2-tap FFE 5-tap DFE in the RX provide channel compensation. BER of <10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-15</sup> measured over legacy backplanes with 24dB loss at Nyquist. The power consumption die area are 330mW 0.45mm xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> per TX/RX pair
Abstract LPS-binding protein (LBP) mediates the pro-inflammatory effects of bacterial LPS by enhancing LPS-induced cytokine production monocytic cells. LBP binds specifically to generate a complex that interacts with CD14 receptor on surface responsive To identify biologically active regions responsible for mediating these activities, we cloned and expressed human rLBP (456 amino acids) as well truncated form encoding acids 1-197 (rLBP25). Both forms bound same affinity, similarly inhibited...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSativene, Parent of the Toxin from Helminthosporium sativumP. de Mayo and R. E. WilliamsCite this: J. Am. Chem. Soc. 1965, 87, 14, 3275Publication Date (Print):July 1, 1965Publication History Published online1 May 2002Published inissue 1 July 1965https://pubs.acs.org/doi/10.1021/ja01092a066https://doi.org/10.1021/ja01092a066research-articleACS PublicationsRequest reuse permissionsArticle Views178Altmetric-Citations36LEARN ABOUT THESE METRICSArticle...
Carcinogenic potency is a key factor in the understanding of chemical risk assessment. Measures carcinogenic potency, for example TD
Abstract: The expression of 34 transmitter‐related genes has been examined in the cholinergic neurones rat striatal brain slices, with aim correlating gene functional activity. mRNAs encoding types I, II/IIA, and III α subunits voltage‐sensitive sodium channels were detected, suggesting presence these three channel. Similarly, all four α‐amino‐3‐hydroxy‐5‐methyl‐isoxazole‐4‐propionate (AMPA)‐type glutamate receptor NR1 NR2A, 2B, 2D NMDA‐type receptors that various combinations mediate...
Altered expression of genes can have phenotypic consequences in cancer development and treatment, developmental abnormalities, differentiation processes. Here we describe a rapid approach, termed comparative expressed sequence hybridization (CESH), which gives genome-wide view relative patterns within tissues according to chromosomal location. No prior knowledge or cloning is required, minimal amounts tissue be used. Expression profiles are achieved manner similar the identification...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAffinities of phosphoric acids, esters, and amides for solvent waterRichard Wolfenden Richard WilliamsCite this: J. Am. Chem. Soc. 1983, 105, 4, 1028–1031Publication Date (Print):February 1, 1983Publication History Published online1 May 2002Published inissue 1 February 1983https://pubs.acs.org/doi/10.1021/ja00342a063https://doi.org/10.1021/ja00342a063research-articleACS PublicationsRequest reuse permissionsArticle Views194Altmetric-Citations31LEARN...
A simple, rapid, and highly sensitive technique is described for the detection of endoglucanase endoxylanase in isoelectric-focused gels. Agar substrate gels containing 0.1% carboxymethyl cellulose or xylan are prepared on GelBond® plastic film placed contact with an electrofocused gel enzymes under study. Hydrolysis zones visualized by staining Congo red. As little as 1 ng enzyme detected 5 min using this technique.
While screening for germline CHK2 mutations in cancer cases by heteroduplex CSGE, we observed that additional PCR fragments were generated from the 3' end region of gene includes exons 11-14. Direct sequencing these suggested homologous loci (possibly pseudogenes) concomitantly being amplified. Searches public sequence databases showed a number areas genome show high degree homology to 10-14 gene. The presence regions means standard methods detecting CHK2, based on genomic DNA, are prone...
It has been previously demonstrated that maley-lated-BSA (maleyl-albumin) induces functional activation in murine peritoneal macrophages. Furthermore, maleyl-albumin shown to interact with two distinct sites on human monocytes; one site is the scavenger receptor, a 260-kDa oligomeric protein which recognizes modified forms of low density lipoprotein (LDL), and second lower affinity yet be structurally characterized. In present study, we wished quantitatively assess number character...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvent water and the biological group-transfer potential of phosphoric carboxylic anhydridesRichard Wolfenden Richard WilliamsCite this: J. Am. Chem. Soc. 1985, 107, 14, 4345–4346Publication Date (Print):July 1, 1985Publication History Published online1 May 2002Published inissue 1 July 1985https://pubs.acs.org/doi/10.1021/ja00300a053https://doi.org/10.1021/ja00300a053research-articleACS PublicationsRequest reuse permissionsArticle...
In crustaceans, a range of physiological processes involved in ovarian maturation occurs organs the cephalothorax including hepatopancrease, mandibular and Y-organ.Additionally, reproduction is regulated by neuropeptide hormones other proteins released from secretory sites within eyestalk.Reproductive dysfunction captive-reared prawns, Penaeus monodon, believed to be due deficiencies these factors.In this study, we investigated expression gene transcripts eyestalk wild-caught animals...