A5032638976- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- HIV, Drug Use, Sexual Risk
- Cervical Cancer and HPV Research
- HIV/AIDS Research and Interventions
- Poxvirus research and outbreaks
- Bacterial Infections and Vaccines
- Zoonotic diseases and public health
- Escherichia coli research studies
- Bacillus and Francisella bacterial research
- Virology and Viral Diseases
- Hepatitis B Virus Studies
- Prion Diseases and Protein Misfolding
- Adolescent Sexual and Reproductive Health
- Vaccine Coverage and Hesitancy
- Herpesvirus Infections and Treatments
- Antibiotic Resistance in Bacteria
- Sex work and related issues
- Viral gastroenteritis research and epidemiology
- HIV, TB, and STIs Epidemiology
- Hepatitis C virus research
- HIV/AIDS Impact and Responses
- T-cell and Retrovirus Studies
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
UK Health Security Agency
2022-2025
Public Health England
2016-2022
John Radcliffe Hospital
2014
Health Protection Scotland
2010-2013
GTx (United States)
2006
Health Protection Agency
2005
After community transmission of monkeypox virus was identified in Europe, interviews 45 case-patients from England indicated international sexual networks gay and bisexual men since April 2022. Interventions targeting sex-on-premises venues, geospatial dating applications, health services are likely to be critical for outbreak control.
Shigellosis, also known as bacillary dysentery, is caused by Shigella spp that spread through fecal-oral contact and was traditionally associated with international travel in England. However, sexual transmission of flexneri sonnei among gay, bisexual, other men who have sex (MSM) now common. In September, 2021, emergence extensively drug-resistant (XDR) S harbouring plasmid-encoded blaCTX-M-27 raised concerns over further this extended-spectrum β-lactamase-producing gene. Using national...
To describe the proportion of HIV-infected heterosexual individuals diagnosed late and estimate how much mortality could have been prevented by earlier diagnosis.A population-based study using surveillance reports from England Wales.Calculation proportions (CD4 cell count < 200 cells/mul) short-term (death within a year diagnosis).A total 16 375 were with HIV (2000-2004): 10 503 CD4 counts available at that time; 42% (4425) late. Late diagnosis increased age (P 0.01). One fifth women...
A surveillance study to determine the incidence, aetiology, and outcome of bacterial meningitis in infants aged <90 days across UK Ireland during July 2010–July 2011 shows that incidence has not changed since 1980s. Background. Bacterial remains a major cause morbidity mortality young infants. Understanding epidemiology burden disease is important. Methods. Prospective, enhanced, national population-based active was undertaken etiology, United Kingdom Ireland. Results. During 2011, 364 cases...
Between December 2021 and June 2022, 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae (ST8123; n = 8) were detected in the United Kingdom, compared with nine during previous 6 years. Most these associated travel from Asia-Pacific region; all heterosexual people, most their 20s. Although successfully treated, not partners could be traced, there is a risk further transmission gonococcal infection within UK.
BackgroundThe 2022–2024 global mpox outbreak, occurring primarily in the sexual networks of gay, bisexual and other men who have sex with (GBMSM), has not been accompanied by a focus on patient perspectives illness. We explore experiences GBMSM diagnosed England to understand needs for social clinical support.MethodsIn-depth interviews (March/July 2023) were conducted 22 2022, randomly selected from national surveillance database, 4 stakeholders clinical/community-based organisations....
To present national trends of the estimated number and proportion late HIV diagnoses short-term mortality following diagnosis among men who have had sex with (MSM). determine separately risk factors for mortality.Analysis HIV/AIDS case reports new linked to CD4 cell counts from Surveillance Scheme. Inverse probability weighting adjusted individuals no count at diagnosis. Outcomes were (CD4 <200 x 10(6) cells/l diagnosis) (death within 1 year diagnosis).Of 14,158 diagnoses, 31% as diagnoses....
Background and methods The national immunisation records of over 220 000 girls offered vaccine in the routine or catch-up programme Human papillomavirus (HPV) Scotland were analysed. Descriptive statistics multilevel modelling used to determine individual organisational factors associated with uptake. Age, school year, denomination, deprivation and, for school-leavers, mode delivery explored. Additional aggregate data examine effect late uptake missed doses vaccination programme. Results...
Abstract Widespread dietary exposure of the population Britain to bovine spongiform encephalopathy (BSE) prions in 1980s and 1990s led emergence variant Creutzfeldt-Jakob Disease (vCJD) humans. Two previous appendectomy sample surveys (Appendix-1 -2) estimated prevalence abnormal prion protein (PrP) British exposed BSE be 237 per million 493 million, respectively. The Appendix-3 survey was recommended measure PrP groups thought have been unexposed BSE. Immunohistochemistry for performed on...
Abstract After lifting of all COVID-19 preventive measures in England July 2021, marked, widespread increases gonorrhea diagnoses, but not testing numbers, were observed, particularly persons 15–24 years age. Continued close surveillance and public health messaging to young are needed control prevent transmission.
Hepatitis C virus (HCV) is the second largest contributor to liver disease in UK, with injecting drug use as main risk factor among estimated 200 000 people currently infected. Despite effective prevention interventions, chronic HCV prevalence remains around 40% who inject drugs (PWID). New direct-acting antiviral (DAA) therapies combine high cure rates (>90%) and short treatment duration (8 12 weeks). Theoretical mathematical modelling evidence suggests scale-up can prevent transmission...
Syphilis is a sexually transmitted bacterial infection caused by Treponema pallidum subspecies pallidum. Since 2012, syphilis rates have risen dramatically in many high-income countries, including England. Although this increase prevalence known to be associated with high-risk sexual activity gay, bisexual, and other men who sex (GBMSM), cases are rising heterosexual women. The transmission dynamics within between networks of GBMSM people not well understood. We aimed investigate if whole...
Objective: To describe the epidemiology of HIV infection acquired in Africa and among African communities United Kingdom. Design: Descriptive analysis using national AIDS surveillance data, routine voluntary confidential reporting unlinked anonymous seroprevalence surveys Kingdom to end December 2001. Results: Of all reported infections diagnosed by 2001, 21% (9993 48 226) were probably 90% these heterosexually acquired. Numbers diagnoses have been increasing rapidly, with rises from...
The 2024 UK guidelines for the management of syphilis are in line with current evidence and practice within UK. Key updates detailed at start article. These accompanied by first pregnant people children, 2024.
Abstract Objectives Since June 2022, there has been a rise in the number of ceftriaxone-resistant Neisseria gonorrhoeae cases detected England (n = 15), which third were XDR. We describe demographic and clinical details recent investigate phenotypic molecular characteristics isolates. For comprehensive overview, we also reviewed 16 previously identified since December 2015 performed global genomic comparison all publicly available N. strains with mosaic penA alleles. Methods All isolates...
The Blood Services of the UK permanently de-select men who have had sex with (MSM) from donating blood. rationale for this has been questioned. This article attempts to evaluate whether selection criterion does contribute blood safety.Data about transfusion-transmissible infections, in particular human immunodeficiency virus (HIV) infection, were used de-selection MSM meets aims donor selection. Models constructed estimate risk HIV-infectious donations entering supply should be changed.Many...
Of the 58,186 coronavirus deaths among adults in England during March-December 2020, 77% occurred hospitals, 93% were patients >60 years, and 91% within 28 days of positive specimen. Cumulative mortality rates highest persons Black, Asian, other, or mixed ethnicities socioeconomically deprived areas.
Abstract England, like other countries that experienced a large outbreak of emergent mpox in 2022, continued to record cases during 2023 at low but steady frequency. Comprehensive national surveillance shows continue occur primarily among gay, bisexual and men who have sex with mostly London. Of 137 2023, around half were acquired overseas, vaccinated, one case reinfection was reported. Eleven people required hospital care. High vaccination uptake, has provided good coverage those higher...
Abstract Background Antimicrobial resistance in Neisseria gonorrhoeae is a global public health concern. Tetracycline (TetR) increased from 39.4% to 75.2% between 2016 and 2021 N. isolates collected through national surveillance England, despite the absence of use tetracyclines for treatment gonorrhoea. Objectives We investigated whether there was correlation bacterial sexually transmitted infection (STI) tests performed with antimicrobials, TetR gonorrhoeae. Methods examined correlations...