A5013765890- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Tuberculosis Research and Epidemiology
- Synthesis and biological activity
- Crystallography and molecular interactions
- Sports Performance and Training
- Multicomponent Synthesis of Heterocycles
- Physical Education and Sports Studies
- Chemical Synthesis and Reactions
- Sports Analytics and Performance
- Analytical Chemistry and Chromatography
- Asymmetric Synthesis and Catalysis
- Sport Psychology and Performance
- Drug Solubulity and Delivery Systems
- Chemical Synthesis and Analysis
- Motivation and Self-Concept in Sports
- Cancer therapeutics and mechanisms
- Nonlinear Optical Materials Research
- Natural Antidiabetic Agents Studies
- Organophosphorus compounds synthesis
- Infectious Diseases and Tuberculosis
- Free Radicals and Antioxidants
- Carbohydrate Chemistry and Synthesis
- Inorganic and Organometallic Chemistry
- Synthesis and Biological Evaluation
Universidade Federal de Viçosa
2014-2020
Universidade Federal de Juiz de Fora
2007-2019
Universidade Federal de Lavras
2010
Universidade Federal de Minas Gerais
2010
Nanoenabled drug delivery systems against tuberculosis (TB) are thought to control pathogen replication by targeting antibiotics infected tissues and phagocytes. However, whether nanoparticle (NP)-based carriers directly interact with Mycobacterium how such induce intracellular bacterial killing macrophages is not defined. In the present study, we demonstrated that a highly hydrophobic citral-derived isoniazid analogue, termed JVA, significantly increases nanoencapsulation inhibits M. growth...
Me-β-cyclodextrin (Me-βCD) and HP-β-cyclodextrin (HP-βCD) inclusion complexes with isoniazid (INH) were prepared the aim of modulating physicochemical biopharmaceutical properties guest molecule, a well-known antibuberculosis drug. The architectures initially proposed according to NMR data Job plot ROESY followed by density functional theory (DFT) calculations (1)H spectra using PBE1PBE 6-31G(d,p) basis set, including water solvent effect polarizable continuum model (PCM), for various modes,...
Density functional theory (DFT) calculations of 1 H NMR chemical shifts for l ‐quebrachitol isomers were performed using the B3LYP employing 6‐31G(d,p) and 6‐311 + G(2d,p) basis sets. The effect solvent on B3LYP‐calculated spectrum was accounted polarizable continuum model. Comparison is made with experimental spectroscopic data, which shed light average uncertainty present in DFT showed that best match between theoretical profiles a good strategy to assign molecular structure sample handled...
The study aimed to compare the decision-making and visual search strategies of young soccer players between two groups based on results on-field specific tactical test. Ninety youth male (14.0 ± 1.06 years) affiliated regional Brazilian clubs participated in this (U-15 years). behaviour was assessed using FUT-SAT assessment tool were grouped into skill level: more skilled less skilled. Video-based tests used assess decision-making, while performed Mobile Eye-XG®. indicated that showed better...
The aim of the present study was to compare visual search strategy (VSS) and anticipation between two groups young players different efficiencies in tactical behavior (TB). A total 44 Brazilian male soccer aged 14.00 (± 1.06) years from three regional clubs participated study. TB assessed using FUT-SAT; score obtained by a video-based assessment, while VSS performed Mobile Eye-XG® system. were divided into based on their results those more efficient less efficient. showed that with higher...
The thiazole and imidazole nucleus, as well carbohydrates are important classes of compounds found in many natural synthetic products with a wide range biological activities. Due to the importance these antimicrobial agents, present article reports synthesis new series nine based on coupling 2-mercaptobenzothiazole 2-mercaptobenzimidazole different carbohydrates.
Two new <italic>p</italic>-sulfonic acid calix[4]arene- and calix[6]arene-functionalized organosilica have been synthesized using a sol–gel method applied as heterogeneous catalysts in esterification reactions.
Two synthetic epoxide derivatives, important intermediates in organic synthesis, were obtained from L-quebrachitol, and their conformations proposed based on spectroscopic analysis. Density functional theory (DFT) calculations of infrared NMR spectra shown to be reliable enough for chemistry applications. The observed structures determined with the aid DFT data, stressing relevance utility combined experimental/theoretical studies also usefulness (13)C B3LYP/6-31G(d,p) calculations.
The use of star anise oil from a natural source as dienophile in the multicomponent double Povarov reaction (MCPRs) to produce highly substituted julolidines with diverse technological applications is described. Within framework green chemistry, these MCPRs have many advantages such (i) water reaction, (ii) creation up six bonds one sequence, (iii) sole waste, (iv) 100% carbon economy, (v) metal-free process, and (vi) nontoxic reusable organocatalysts. These advantages, along simple workup...
This study proposes the use of a computational approach based on machine learning (ML) algorithms to build predictive models using eye tracking data. Our intention is provide results that may support medical investigation in decision-making process clinical bioethics, particularly this work, cases euthanasia. The data used were collected from 75 students nursing undergraduate course an tracker. available processed through feature selection methods, and later create capable predicting...
A series of 13 compounds analogous isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test the expressed as minimum inhibitory concentration (MIC90) μg/mL. Several exhibited antitubercular (0.31-3.12 μg/mL) when compared first line drugs such (INH) rifampicin (RIP) could be a good starting point to develop new tuberculosis.
This work describes the synthesis of inositol derivatives condensed with 2‐mercaptobenzothiazole or 2‐mercaptobenzimidazole, potential antimicrobial agents. These compounds were prepared by ring opening epoxide intermediate (2 S ,3 R ‐epoxy‐1‐ O ‐methyl‐ l ‐ chiro ‐inositol and 2 ‐inositol), which obtained from ‐quebrachitol (1‐ ‐inositol). Microwave irradiation was used to promote condensation reaction.
Multidrug-resistant tuberculosis (MDR-TB) is a serious problem worldwide, especially in people living with human immunodeficiency virus. In considering the MDR-TB problem, ethionamide (ETH) structural analog of isoniazid that typically used when patient exhibits resistance to front-line drugs, being one most frequently for treatment drug-resistant tuberculosis. Due importance ETH TB treatment, aim our work was synthesis and characterization oxazolinyl (1,2) N-hydroxyalkyl (3–5) derivatives.