A5011716899- Synthesis and biological activity
- Science and Education Research
- Tuberculosis Research and Epidemiology
- Neuroscience and Neuropharmacology Research
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Neural dynamics and brain function
- Chemistry Education and Research
- Education Pedagogy and Practices
- Biochemical and Molecular Research
- Education during COVID-19 pandemic
- Healthcare during COVID-19 Pandemic
- Education and Digital Technologies
- Hearing, Cochlea, Tinnitus, Genetics
- Digestive system and related health
- Bioactive Compounds and Antitumor Agents
- Computational Drug Discovery Methods
- Multicomponent Synthesis of Heterocycles
- Geography and Environmental Studies
- Environmental Sustainability and Education
- Acute Myeloid Leukemia Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Chronic Lymphocytic Leukemia Research
- Biomedical and Engineering Education
- Linguistics and Education Research
Universidade Federal de Alagoas
2011-2024
Universidade Estadual do Oeste do Paraná
2023
Universidade Estadual de Campinas (UNICAMP)
2016
Universidade Católica Portuguesa
2014
Universidade Federal de Juiz de Fora
2003-2009
Universidade de São Paulo
1992-2007
Hospital Israelita Albert Einstein
2005
Universidade Federal de Uberlândia
2001
Seevic College
1992
Cancer represents the main cause of morbidity and mortality worldwide, constituting a serious health problem. In this context, melanoma most aggressive fatal type skin cancer, with death rates increasing every year. Scientific efforts have been addressed to development inhibitors targeting tyrosinase enzyme as potential anti-melanoma agents due importance in melanogenesis biosynthesis. Coumarin-based compounds shown activity inhibitors. study, coumarin-based derivatives were designed,...
Este estudo examina a interseccionalidade entre igualdade de gênero, direito e educação no Ensino Fundamental II em Marabá, Pará. O objetivo é analisar como legislação as políticas educacionais abordam essa temática identificar desafios na sua implementação. marco teórico fundamenta-se nas bases jurídicas normativas, bem teorias sociais sobre gênero educação, que orientam promoção da equidade escolas. A pesquisa, abordagem qualitativa quantitativa, baseia-se revisão bibliográfica documental,...
The natural product tetrahydrolathyrine has been synthesized through an iminoiodane-mediated aziridination of a (2S)-allylglycinol derivative, which provided 2:3 mixture diastereoisomers. One these diastereoisomers was converted to the and other its C-4 epimer. configuration established from NOESY NMR analysis X-ray structure compounds derived non-natural diastereoisomer. Thus, shown have (2S,4R) absolute configuration.
The inferior colliculus (IC) is a well known relay station for auditory pathways in the brainstem. Much evidence has implicated this structure as part of brain system mediating aversive states, and changes its functioning responsible occurrence audiogenic seizures. Rats were implanted with chemitrodes, devices which allow electrical stimulation microinjections drugs same sites. Stepwise increases intensity IC rats placed inside circular arena allowed determination thresholds freezing escape...
The thiazole and imidazole nucleus, as well carbohydrates are important classes of compounds found in many natural synthetic products with a wide range biological activities. Due to the importance these antimicrobial agents, present article reports synthesis new series nine based on coupling 2-mercaptobenzothiazole 2-mercaptobenzimidazole different carbohydrates.
Fourteen thalidomide analogs bearing two phthalimido units were prepared in high yields (83—94%) by condensation of different diamines with phthalic or 3-nitrophthalic anhydride. An vitro investigation the compounds as inhibitors TNF-α production was performed. The inhibition higher for amino and nitro groups modulated increasing size spacers between phthalimide groups.
A series of C-2 and C-6 substituted pyridines was synthesized evaluated in vitro against Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans Candida albicans. Most compounds exhibited a wide range modest activity the tested microorganisms. Keywords: Substituted pyridines, Amide, Antimicrobial activity, Synthesis
A series of 13 compounds analogous isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test the expressed as minimum inhibitory concentration (MIC90) μg/mL. Several exhibited antitubercular (0.31-3.12 μg/mL) when compared first line drugs such (INH) rifampicin (RIP) could be a good starting point to develop new tuberculosis.
Trypanosoma cruzi (Chagas diseases – also named American trypanosomiasis) and T. brucei (human African trypanosomiasis HAT) negatively impact public health, being endemic in several countries leading to thousands of deaths per year.
In general, a cancerous process starts from uncontrolled cell growth, apoptosis, and rapid proliferation of cellular clones, as well as, reactive oxygen species (ROS) imbalance ROS-antioxidant production also could be involved in the genesis disease. Cancer has accounted for millions deaths worldwide every year, representing relevant threat to human lives. this context, malignant melanoma represents most aggressive deadliest type cancer, leading increased rates patient deaths. Natural active...
Multidrug-resistant tuberculosis (MDR-TB) is a serious problem worldwide, especially in people living with human immunodeficiency virus. In considering the MDR-TB problem, ethionamide (ETH) structural analog of isoniazid that typically used when patient exhibits resistance to front-line drugs, being one most frequently for treatment drug-resistant tuberculosis. Due importance ETH TB treatment, aim our work was synthesis and characterization oxazolinyl (1,2) N-hydroxyalkyl (3–5) derivatives.
A leucemia promielocítica aguda (LPA) corresponde a 10% -15% das leucemias mielóides agudas (LMA). Este tipo de (LMA-M3 acordo com classificação FAB) está associado, em cerca 90% dos casos, à translocação t(15;17)(q22;q21), que resulta na fusão genes PML e RARalfa. análise citogenética tradicional tem sido utilizada para confirmar o diagnóstico morfológico da LPA. Embora t(15;17) não seja detectada outros tipos leucemia, podem ocorrer resultados "falso-negativos", decorrentes células...
espanolEl concepto de Supervision Pedagogica no es reciente, sin embargo, en el siglo xxi, ha ganado nuevos significados y un estatuto mayor relevancia Portugal, la medida que forma parte contexto cambio del ejercicio profesion docente, surgiendo asociado a nuevo paradigma intervencion accion los profesores.En este sentido, formacion continua se asume como factor determinante para mismo, por lo estudio han buscado i) evidencias operacionalizacion procesos supervision Centros Formacion...