A5100674178- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Microbial Community Ecology and Physiology
- DNA Repair Mechanisms
- Bacterial Genetics and Biotechnology
- Wastewater Treatment and Nitrogen Removal
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Bacteriophages and microbial interactions
- Mitochondrial Function and Pathology
- Genomics and Chromatin Dynamics
- DNA and Nucleic Acid Chemistry
- Autophagy in Disease and Therapy
- Human Pose and Action Recognition
- Chromium effects and bioremediation
- Video Surveillance and Tracking Methods
- Blood disorders and treatments
- Carbon dioxide utilization in catalysis
- Surfactants and Colloidal Systems
- Heat shock proteins research
- Covalent Organic Framework Applications
- ATP Synthase and ATPases Research
- Photosynthetic Processes and Mechanisms
- Methane Hydrates and Related Phenomena
- Epigenetics and DNA Methylation
Center for Life Sciences
2016-2025
Peking University
2016-2025
Shenzhen Institutes of Advanced Technology
2023-2025
Institute of Plant Protection
2025
Chinese Academy of Agricultural Sciences
2025
King Center
2025
Nanyang Medical College
2021-2025
Zhejiang University of Technology
2024
Henan Provincial People's Hospital
2024
Zhengzhou University
2014-2024
Kinetics and cryo-electronmicroscopy data provide insights into GTPase ObgE's role as a ribosome anti-association factor that is modulated by nutrient availability, coupling growth control to biosynthesis protein translation.
Immunoglobulin M (IgM) plays a pivotal role in both humoral and mucosal immunity. Its assembly transport depend on the joining chain (J-chain) polymeric immunoglobulin receptor (pIgR), but underlying molecular mechanisms of these processes are unclear. We report cryo-electron microscopy structure Fc region human IgM complex with J-chain pIgR ectodomain. The IgM-Fc pentamer is formed asymmetrically, resembling hexagon missing triangle. tailpieces pack into an amyloid-like to stabilize...
Ribosome biogenesis is an elaborate and energetically expensive program that involve two hundred protein factors in eukaryotes. Nuclear export of pre-ribosomal particles one central step which also serves as internal structural checkpoint to ensure the proper completion nuclear assembly events. Here we present four structures human pre-60S isolated through a factor NMD3, representing stages immediately before after export. These reveal locations dozen factors, including uncharacterized TMA16...
Abstract Tuberous sclerosis complex (TSC) integrates upstream stimuli and regulates cell growth by controlling the activity of mTORC1. TSC functions as a GTPase-activating protein (GAP) towards small GTPase Rheb inhibits Rheb-mediated activation Mutations in genes cause tuberous sclerosis. In this study, near-atomic resolution structure human reveals an arch-shaped architecture, with 2:2:1 stoichiometry TSC1, TSC2, TBC1D7. This asymmetric consists two interweaved TSC1 coiled-coil one TBC1D7...
Regional bias of N6-methyladenosine (m6A) mRNA modification avoiding splice site region, calls for an open hypothesis whether exon-intron boundary could affect m6A deposition. By deep learning modeling, we find that represses a proportion (12% to 34%) deposition at adjacent exons (~100 nt site). Experiments validate signal increases once the host gene does not undergo pre-mRNA splicing produce same mRNA. Inhibited sites have higher enhancers and lower silencers locally show high...
Intestinal bacterial dysbiosis has been increasingly linked to ankylosing spondylitis (AS), which is a prototypic and best studied subtype of spondyloarthritis (SpA). Fungi bacteria coexist in the human gut interact with each other. Although they have shown contribute actively health or disease, no studies investigated whether fungal microbiota AS patients perturbed. In this study, fecal samples from 22 patients, clinical radiographic assessments, 16 healthy controls (HCs) were collected...