A5052068909- Genital Health and Disease
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Diet and metabolism studies
- Autoimmune and Inflammatory Disorders Research
- Gut microbiota and health
- Sodium Intake and Health
- Hedgehog Signaling Pathway Studies
- Hippo pathway signaling and YAP/TAZ
University Hospital Regensburg
2021-2022
University of Regensburg
2021-2022
Dietary high salt (HS) is a leading risk factor for mortality and morbidity. Serum sodium transiently increases postprandially but can also accumulate at sites of inflammation affecting differentiation function innate adaptive immune cells. Here, we focus on how changes in extracellular sodium, mimicking alterations the circulation tissues, affect early metabolic, transcriptional, functional adaption human murine mononuclear phagocytes.Using Seahorse technology, pulsed stable...
Local tissue acidosis affects anti-tumor immunity. In contrast, data on pH levels in infected tissues and their impact antimicrobial activity is sparse. this study, we assessed the cutaneous Leishmania lesions. major-infected skin displayed of 6.7 indicating that lesional acidic. Next, tested effect low extracellular ability macrophages to produce leishmanicidal NO fight protozoan parasite major. Extracellular acidification led a marked decrease both production lipopolysaccharide (LPS)...