A5013598105- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant Reproductive Biology
University of Münster
2020-2024
University Hospital Münster
2020-2024
The infertility of many couples rests on an enigmatic dysfunction the man's sperm. To gain insight into underlying pathomechanisms, we assessed function sperm-specific multisubunit CatSper-channel complex in sperm almost 2,300 men undergoing a fertility workup, using simple motility-based test. We identified group with normal semen parameters but defective CatSper function. These or failed to conceive naturally and upon medically assisted reproduction via intrauterine insemination vitro...
Article19 January 2020Open Access Transparent process Rotational motion and rheotaxis of human sperm do not require functional CatSper channels transmembrane Ca2+ signaling Christian Schiffer Centre Reproductive Medicine Andrology, University Hospital Münster, Germany Search for more papers by this author Steffen Rieger Optical Technologies Group, Institute Applied Physics, Christoph Brenker Samuel Young Hussein Hamzeh orcid.org/0000-0002-3056-788X Molecular Sensory Systems, Center Advanced...
The infertility of many couples seems to rest on an enigmatic dysfunction the men’s sperm, rendering early diagnosis and evidence-based treatment by medically assisted reproduction impossible. Using a novel laboratory test, we assessed function flagellar Ca 2+ channel CatSper in sperm almost 2,300 men undergoing fertility workup. Thereby, identified group with mutations CATSPER genes affecting channel. Although standard semen computer-assisted analysis were unremarkable, required...