A5023189649- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive Health and Technologies
- Pluripotent Stem Cells Research
- Chemokine receptors and signaling
- Renal and related cancers
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Testicular diseases and treatments
- Sexual Differentiation and Disorders
University Hospital Münster
2018-2024
University of Münster
2022-2024
The infertility of many couples rests on an enigmatic dysfunction the man's sperm. To gain insight into underlying pathomechanisms, we assessed function sperm-specific multisubunit CatSper-channel complex in sperm almost 2,300 men undergoing a fertility workup, using simple motility-based test. We identified group with normal semen parameters but defective CatSper function. These or failed to conceive naturally and upon medically assisted reproduction via intrauterine insemination vitro...
Can a systematic scoring procedure provide crucial information on the status of highly heterogeneous immature human testicular tissues in context cryopreservation for fertility preservation? We developed histological score as novel diagnostic tool which differentiates patient cohort according to germ cell differentiation and number spermatogonia (normal, diminished absent), could be relevant clinic. Cryopreservation tissue boys is currently considered option future restoration. However,...
The infertility of many couples seems to rest on an enigmatic dysfunction the men’s sperm, rendering early diagnosis and evidence-based treatment by medically assisted reproduction impossible. Using a novel laboratory test, we assessed function flagellar Ca 2+ channel CatSper in sperm almost 2,300 men undergoing fertility workup. Thereby, identified group with mutations CATSPER genes affecting channel. Although standard semen computer-assisted analysis were unremarkable, required...
Abstract Study question Are there differences in fertilization and pregnancy rates post-TESE-ICSI between motile immotile sperm, do these vary treatments with without calcium ionophore? Summary answer Post-TESE-ICSI data reveals when comparing vs. sperm ionophore after TESE-ICSI. What is known already Testicular extraction (TESE) followed by intracytoplasmic injection (ICSI) poses a challenge for every IVF laboratory. This particularly true patients exhibiting azoospermia, where only few...
Growth factors became attractive candidates for medium supplementation to further improve the quality of embryo culture and mimic in vivo nutrition. Granulocyte macrophage colony-stimulating factor (GM-CSF) is a cytokine influencing maternal-fetal interface supporting placental development mouse human. It expressed epithelial cells endometrium under regulation estrogens. The already clinical use large trial showed that, if supplemented an medium, it leads increased survival embryos,...
Abstract Study question Is a loss of CatSper function in sperm common cause unexplained male infertility? Summary answer Loss leads to similar infertility phenotypes mice and men represents one the most causes infertility. What is known already Male often due low counts, impaired motility, and/or abnormal morphology. However, for large fraction infertile men, semen parameters are normal, suggesting that rather an dysfunction sperm. There has been growing body evidence human might involve...