A5011337900- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- Breast Cancer Treatment Studies
- Eosinophilic Disorders and Syndromes
- Melanoma and MAPK Pathways
- Salivary Gland Tumors Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Sarcoidosis and Beryllium Toxicity Research
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Ovarian cancer diagnosis and treatment
- Intraperitoneal and Appendiceal Malignancies
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- HER2/EGFR in Cancer Research
- Neuroendocrine Tumor Research Advances
- Breast Lesions and Carcinomas
- Molecular Biology Techniques and Applications
- Advanced Breast Cancer Therapies
- Head and Neck Anomalies
- Cytomegalovirus and herpesvirus research
- Biliary and Gastrointestinal Fistulas
- Testicular diseases and treatments
- Colorectal Cancer Treatments and Studies
Ospedale Santa Chiara
2021-2025
Provincia Autonoma di Trento
2023
University of Genoa
2016-2021
Nottingham University Hospitals NHS Trust
2020-2021
University of Nottingham
2020-2021
Nottingham City Hospital
2020-2021
Ospedale Policlinico San Martino
2016-2021
In the DESTINY-Gastric01 trial, a novel HER2-targeted antibody-drug conjugate trastuzumab deruxtecan proved to be effective in HER2-low gastro-oesophageal adenocarcinomas. The aim of our study is investigate clinicopathological and molecular features gastric/gastro-oesophageal junction cancers real-world setting large multi-Institutional series.We retrospectively evaluated 1210 formalin-fixed paraffin-embedded samples adenocarcinomas which were analysed by immunohistochemistry for HER2...
Estrogen receptor (ER)-positive breast cancer (BC) is the most common BC subtype. Endocrine therapy (ET) targeting ER signaling still remains mainstay treatment option for hormone (HR)-positive either in early or advanced setting, including different strategies, such as suppression of estrogen production directly blocking pathway through SERMs—selective modulators—or SERDs—selective degraders. Nevertheless, development de novo acquired endocrine resistance challenging oncologists. The use...
Lung fibrosis has specific computed tomography (CT) findings and represents a common finding in advanced COVID-19 pneumonia whose reversibility been poorly investigated. The aim of this study was to quantify the extension collagen deposition aeration postmortem cryobiopsies critically ill patients describe correlations with qualitative quantitative analyses lung CT. Postmortem transbronchial cryobiopsy samples were obtained, formalin fixed, paraffin embedded stained Sirius red deposition,...
Identifying innovative molecules involved in the tumor immune escape process could help refine survival stratification of colorectal cancer (CRC) patients. HLA-G, a non-classical HLA molecule, physiologically tolerogenic mechanisms, has recently emerged as relevant prognostic marker other types, but ambiguous data are reported CRC setting. This study aims to evaluate HLA-G expression and potential series stage II/III CRCs. was evaluated 100 pT3 cases by means immunohistochemistry using 4H84...
Pathology archives are a treasure trove of paraffin embedded tissue spanning many years and covering wide variety tissues diseases. The possibility using old archival formalin fixed (FFPE) for diagnostic updates research projects is widespread need it requires stable, well-preserved samples. Immunohistochemistry performed on blocks may give unreliable results, in particular some antigens, such as Ki67. In consideration this phenomenon, our aim to comprehensively test identify methods which...
Glucose-regulated protein94 (Grp94), the most represented endoplasmic reticulum (ER)-resident heat shock protein (HSP), is a tumor antigen shared by different types of solid and hematological tumors. The tumor-specific feature Grp94 its translocation from ER to cell surface where it displays pro-oncogenic functions. This un-physiological location has important implications for both pathology anti-tumor therapy. We wanted address question whether could be measured as liquid marker in cancer...
Dasatinib is a second-generation multityrosine kinase inhibitor used in the first-line and second-line treatment of Philadelphia chromosome-positive leukaemia. The most frequent type Dasatinib-induced intestinal injury haemorrhagic colitis; other morphologic patterns include apoptotic colopathy, CD8+ T-cell-mediated colitis non-specific colitis. Aim this study to describe novel Crohn's-like histopathologic pattern Four patients developed diarrhoea during treatment; colonoscopy was performed...
Phyllodes tumours (PT) are rare and distinct breast tumours, which span a morphological continuum. Classification into benign, borderline malignant categories reflects their biology clinical behaviour is essential to guide management. This study aims assess the diagnostic agreement of PT using UK National Health Service Breast Screening Programme (NHSBSP) pathology external quality assurance (EQA) scheme data.Twenty-six PTs were identified in EQA scheme, diagnosed by an average 607...
Thyroid ectopia is a rare finding below the diaphragm. It characterized by normal thyroid parenchyma in unusual locations with preserved marker immunoreactivity. In this article, we present first known case of tissue periappendiceal fat and discuss possible ethiopathogenic theories.
Phyllodes tumours (PTs) represent an unusual but complex group of breast lesions with a tendency to recur locally and, less commonly, metastasise. On core biopsies, their appearances can be difficult discriminate from those other fibroepithelial lesions, which may compromise surgical management. The aims this study were assess the preoperative diagnosis PTs and evaluate impacts management morphological features on behaviour.We combined datasets three centres over two decades, including...
Toxoplasma gondii is an obligate intracellular parasite (Protozoa family), generally hosted by cats and transmitted to humans contact or eating undercooked infected meat. Infected individuals are usually asymptomatic, but immunocompromised persons may be severely affected: central nervous system (CNS) involvement a typical complication of HIV/AIDS patients. It the leading infectious cause focal space-occupying lesions in hemispheres basal nuclei.1 However, subtentorial toxoplasmosis with...