About
Contact & Profiles
A5069061180
Research Areas
- CAR-T cell therapy research
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Viral Infectious Diseases and Gene Expression in Insects
- Nanowire Synthesis and Applications
Korea Advanced Institute of Science and Technology
2022-2023
Background The incorporation of co-stimulatory signaling domains into second-generation chimeric antigen receptors (CARs) significantly enhances the proliferation and persistence CAR-T cells in vivo, leading to successful clinical outcomes. Methods To achieve such functional enhancement transgenic T-cell receptor-engineered (TCR-T) therapy, we designed a TCR-T cell which CD3ζ genes modified contain intracellular domain (ICD) 4-1BB receptor were selectively inserted CD247 locus. Results This...
10.1136/jitc-2022-005519
article
EN
cc-by-nc
Journal for ImmunoTherapy of Cancer
2023-04-01
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