A5101441810- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Orthopedic Infections and Treatments
- Pharmacogenetics and Drug Metabolism
- Advanced Nanomaterials in Catalysis
- Ionic liquids properties and applications
- Crystal structures of chemical compounds
- Metal-Organic Frameworks: Synthesis and Applications
- Zebrafish Biomedical Research Applications
- Liver Disease Diagnosis and Treatment
- Inorganic Fluorides and Related Compounds
- Fluoride Effects and Removal
- Glioma Diagnosis and Treatment
- RNA Research and Splicing
- Circular RNAs in diseases
- Advanced Fluorescence Microscopy Techniques
- Chemical and Physical Properties in Aqueous Solutions
- Eicosanoids and Hypertension Pharmacology
- Metal complexes synthesis and properties
- Hormonal Regulation and Hypertension
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Cell Image Analysis Techniques
- Chemical Analysis and Environmental Impact
People's Hospital of Cangzhou
2023
Baotou Medical College
2020-2022
Lanzhou University
2019-2020
Lanzhou University Second Hospital
2019-2020
Shanghai Eighth People Hospital
2018
Jiangsu University
2018
University of California, San Francisco
2016
Abstract Background Long non-coding RNAs (LncRNAs) are recognized as a pivotal element in the processes of fracture healing and osteogenic differentiation stem cells. This study investigated molecular mechanism regulatory significance lncRNA MAGI2-AS3 (MAGI2-AS3) healing. Methods Serum levels patients with normal delayed were verified by RT-qPCR assays. The predictive efficacy for was analyzed ROC curve. Osteogenic markers quantified MC3T3-E1 cell viability detected using CCK-8 assay, flow...
Glioblastoma multiforme (GBM) is the most common in situ neoplasms central nervous system (CNS). However, pathogenesis of GBM poorly understood. Long noncoding RNAs (lncRNAs) have been implicated progression. In this study, we attempted to identify biological role EGFR-AS1 glioma cells and tissues, as well reveal molecular mechanism associated. The results indicated that lnc-EGFR-AS1 expression was increased tissues. knockdown suppressed proliferation, migration invasion cells, but induced...
Drug discovery in whole-organisms such as zebrafish is a promising approach for identifying biologically-relevant lead compounds. However, high content imaging of at cellular resolution challenging due to the difficulty orienting larvae en masse that cell type interest clear view. We report development multi-pose method, which uses 96-well round bottom plates combined with standard liquid handler repose within each well multiple times, an image specific orientation can be acquired. have...
This study analyzed the miRNA network involved in occurrence and development of renal fibrosis rats using transcriptomics bioinformatics to identify novel diagnostic biomarkers potential therapeutic targets.
Immunogenic cell death (ICD) stimulates adaptive immunity and holds significant promise in cancer therapy. Nevertheless, the influence of ICD-associated long non-coding RNAs (lncRNAs) on prognosis patients with lung squamous carcinoma (LUSC) remains unexplored.We employed data from The Cancer Genome Atlas (TCGA)database to identify ICD-related lncRNAs associated LUSC using univariate Cox regression analysis. Subsequently, we utilized LOSS model construct a predictive risk for assessing based...
Abstract Cell fate determination during early embryonic development is a complex process modulated by gene expression. The intricate interplay of transcriptional and post-transcriptional regulation integral to the developmental trajectory embryogenesis, yet how RNA processing may contribute programming largely elusive. Leveraging recent technological advances in single-molecule nanopore sequencing, we developed single-cell long-read transcriptome sequencing technology, allowing clear view...
Our study attempted to identify hub genes related isocitrate dehydrogenase (IDH) mutation in glioma and develop a prognostic model for IDH-mutant patients. In first step, ten significantly associated with the IDH status were identified by weighted gene coexpression analysis (WGCNA). The functional enrichment demonstrated that most enriched terms of these cadherin binding glutathione metabolism. Three linked survival 328 samples separated into two datasets: training set (N = 228) test 100)....
By using a mixed-ligand approach, new Cu(II)-based coordination polymer (CP) with the chemical formula of {[Cu(tci)(bpy)(NO3)·DMF·0.5CH3CN}n (H3tci = tri(2-carboxyethyl) isocyanurate, bpy 4,4-bipyridine), (1) was synthesized from mixture 4,4-bipyridine and Cu(NO3)2·3H2O under solvothermal conditions. Furthermore, anti-liver cancer activity compound further evaluated. Then reactive oxygen species (ROS) accumulation in cells after treatment In addition to this, relative expression ROS related...