A5007311575- 3D Printing in Biomedical Research
- Nanofabrication and Lithography Techniques
- Neuroscience and Neural Engineering
- Fungal and yeast genetics research
- Pluripotent Stem Cells Research
- Bacterial biofilms and quorum sensing
- Antifungal resistance and susceptibility
Wellcome Centre for Cell-Matrix Research
2019
University of Aberdeen
2017
Most fungal pathogens of humans display robust protective oxidative stress responses that contribute to their pathogenicity. The induction enzymes detoxify reactive oxygen species (ROS) is an essential component these responses. We showed previously ectopic expression the heme-containing catalase enzyme in Candida albicans enhances resistance stress, combinatorial plus cationic and phagocytic killing. Clearly confers fitness advantages presence therefore this study we tested whether it...
Developmental timing differs strikingly between mammals. All embryonic and some placental lineages emerge from the pluripotent epiblast in a temporally defined sequence, lasting about two weeks human embryo, but only days mice. Moreover, order of lineage segregation gene expression differ species. We used stem cells to recapitulate this window development vitro. Simultaneous profiling chromatin accessibility single revealed robust, autonomous switch cell states during process. reconstructed...
Cells sense a variety of extracellular cues, including the composition and geometry matrix, which is synthesized remodeled by cells themselves. Here, we present method Light-Induced Molecular Adsorption Proteins (LIMAP) using PRIMO system as patterning technique to produce micro-patterned matrix (ECM) substrates single or combination proteins. The enables printing ECM patterns in micron resolution with excellent reproducibility. We provide step-by-step protocol demonstrate how this can be...
Cells sense a variety of extracellular cues, including the composition and geometry matrix, which is synthesized remodeled by cells themselves. Here, we present method Light-Induced Molecular Adsorption Proteins (LIMAP) using PRIMO system as patterning technique to produce micro-patterned matrix (ECM) substrates single or combination proteins. The enables printing ECM patterns in micron resolution with excellent reproducibility. We provide step-by-step protocol demonstrate how this can be...