A5103021558- Migraine and Headache Studies
- Multiple Sclerosis Research Studies
- Trigeminal Neuralgia and Treatments
- Vestibular and auditory disorders
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Ophthalmology and Eye Disorders
- Sympathectomy and Hyperhidrosis Treatments
- Botulinum Toxin and Related Neurological Disorders
- Advanced MRI Techniques and Applications
- Glaucoma and retinal disorders
- Peripheral Neuropathies and Disorders
- Ultrasound and Hyperthermia Applications
- Olfactory and Sensory Function Studies
- Cardiovascular Syncope and Autonomic Disorders
- Neurological Disorders and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Lupus Erythematosus Research
- Neurogenesis and neuroplasticity mechanisms
- Polyomavirus and related diseases
- Cerebral Venous Sinus Thrombosis
- Ocular Diseases and Behçet’s Syndrome
- Neurological disorders and treatments
- Neurological Complications and Syndromes
- Parkinson's Disease Mechanisms and Treatments
Vita-Salute San Raffaele University
2016-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2006-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2008-2025
University of Milan
1991-2025
IRCCS Ospedale San Raffaele
2006-2023
San Raffaele University of Rome
2006-2022
Universidade Estadual do Oeste do Paraná
2019
King's College London
2018
Wellcome Trust
2018
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2014-2017
In migraine patients, functional imaging studies have shown changes in several brain gray matter (GM) regions. However, 1.5-T MRI has failed to detect any structural abnormality of these We used a 3-T scanner and voxel-based morphometry (VBM) assess whether GM density abnormalities can be seen patients with T2-visible grade their extent.In 16 15 matched controls, we acquired T2-weighted high-resolution T1-weighted sequence. Lesion loads were measured on images. An optimized version VBM...
<b><i>Objective:</i></b> To identify differences in pathology between the principal clinical phenotypes of MS using conventional and magnetization transfer (MT) MRI. <b><i>Methods:</i></b> T1-weighted T2-weighted images as well MT scans were obtained from 20 controls, 21 patients presenting with clinically isolated syndromes suggestive MS, 93 relapsing-remitting, secondary progressive, benign, or primary progressive course. Metrics considered: hypointense T1 T2 lesion volumes, average ratio,...
Abstract In multiple sclerosis, the mechanisms underlying accumulation of disability are poorly understood. Recently, it has been suggested that adaptive cortical changes may limit clinical impact sclerosis injury. this study, functional magnetic resonance imaging and a general search method were used to assess patterns brain activation associated with simple motor task in 14 right‐handed, nondisabled relapsing‐remitting patients compared those from 15 sex‐ age‐matched healthy volunteers....
To explore the patterns of cortical thickness and surface area abnormalities in patients with migraine (with expectation seeing reduced regions subserving nociception increased involved pathogenesis) to assess their correlation clinical radiologic manifestations disease.Approval local ethical committee was obtained, as well written informed consent from each participant. T2-weighted three-dimensional T1-weighted magnetic resonance images brain were acquired 63 migraineurs 18 matched healthy...
Growing evidence suggests that vitamin D deficiency may be one of the most important environmental factors for development multiple sclerosis (MS).The objectives this paper are to evaluate serum 25-hydroxyvitamin (25(OH)D) levels in patients with clinically isolated syndromes (CIS) and examine whether they related MS risk.This is a retrospective study 100 CIS hospitalized from 2000 2009 at San Raffaele Hospital, Milan, Italy. We evaluated baseline 25(OH)D level as well clinical, brain...
Objectives: Involvement of selected central nervous system (CNS) regions has been associated with depression and fatigue in MS. We assessed whether specific regional patterns lesion distribution atrophy the gray (GM) white matter (WM) are these symptoms Methods: Brain dual-echo 3D T1-weighted images were acquired from 123 MS patients (69 depressed (D), 54 non-depressed (nD), 64 fatigued, 59 non-fatigued) 90 controls. Lesion distribution, GM WM estimated using VBM SPM8. Results: Gender, age,...
To use magnetic resonance (MR) imaging and advanced analysis to assess the role of lesions in normal-appearing white matter ( NAWM ) gray GM damage, global versus regional atrophy microstructural abnormalities pathogenesis fatigue multiple sclerosis MS ).Local ethics committee approval written informed consent were obtained. Dual-echo, double inversion-recovery, high-resolution T1-weighted diffusion-tensor DT diffusion tensor MR was performed 31 fatigued patients, 32 nonfatigued 35 control...
Objective The aim of this work was to assess through a questionnaire the features vertiginous episodes, accompanying symptoms, familial history, and migraine precursors in sample 252 subjects with diagnosis definite vestibular migraine. Background Migraine is common neurological disorder characterized by episodic headaches specific features. About two‐thirds cases run families, patients may refer symptoms occurring infancy childhood, defined as syndromes that be associated vertigo, called...
To assess the effectiveness, safety, and tolerability of erenumab in a real-life migraine population, while trying to identify responsiveness predictors.Erenumab is fully human Ig-2 monoclonal antibody blocking calcitonin gene-related peptide receptor, indicated for prophylaxis. Phase II III trials demonstrated that effective, safe, well tolerated prevention episodic chronic (CM), showing an early onset action.This multicenter, prospective, cohort, study. We considered enrolment all...
Abstract Background and purpose A rapid response to preventive therapy is of pivotal importance in severely disabled patients with chronic migraine (CM) diverse treatment failures. This prospective, observational, multicenter real‐life study aimed at investigating the effectiveness galcanezumab first 3 months CM 14 Italian headache centers. Methods All consecutive adult diagnosis clinical indication for were considered. We collected patients' baseline characteristics, monthly days,...
Abstract Background Monoclonal antibodies anti-calcitonin gene-related peptide (mAbs anti-CGRP) pathway are effective and safe on migraine prevention. However, some drug agencies limited these treatments to one year due their high costs. This study aimed at evaluating the effect of discontinuing mAbs anti-CGRP monthly days (MMDs) disability in high-frequency episodic (HFEM) chronic (CM) patients. Methods observational longitudinal cohort was conducted 10 Italian headache centres. Consecutive...
To assess the frequency and characteristics of late responders (>12 weeks) to monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP).
To verify the long-term (24-week) efficacy, safety, and tolerability of fremanezumab in real-life patients with high-frequency episodic migraine (HFEM: ≥ 8 days/month) or chronic (CM: 15 days/month), multiple preventive treatment failures.This is a prospective, cohort, study at 28 headache centers on consecutive affected by HFEM CM failures who were prescribed subcutaneous (225 mg monthly/675 quarterly) for 24 weeks. Primary endpoint was change monthly days (MMDs) (MHDs) weeks 21-24 compared...
Abstract Objective Nearly 60% of migraine patients treated with monoclonal antibodies (mAbs) targeting the calcitonin gene-related peptide (CGRP) pathway experience a ≥ 50% reduction in monthly days (MMD) at 12 weeks compared to baseline (responders) . However, approximately half not responding anti-CGRP mAbs ≤ do respond 24 ( late responders) We assessed frequency and characteristics only > ultra-late responders ). Methods In this multicenter n = 16), prospective, observational,...
To assess the sensitivities of magnetization transfer imaging (MTI)-derived measures in detecting changes over time macro- and microscopic lesion burdens different MS phenotypes to compare them with those T2-weighted T1-weighted volumes.A total 96 patients were studied: 39 relapsing-remitting (RRMS), 19 secondary progressive (SPMS), nine primary MS, benign MS; 20 clinically isolated syndromes suggestive at presentation; healthy subjects. Brain T2-weighted, T1-weighted, MTI scans obtained...
<b><i>Objective:</i></b> To evaluate the contribution made by cervical cord damage, assessed using a fast short-tau inversion recovery (fast-STIR) sequence and magnetization transfer ratio (MTR) histogram analysis to clinical manifestations of MS. <b><i>Background:</i></b> Previous studies have failed show significant correlations between number extent T2 spinal lesions status patients with Fast-STIR is more sensitive than T2-weighted imaging for detecting MS lesions. MTR provides estimates...
We studied whether a triple dose of gadolinium-DTPA alone or in combination with delayed scanning increases the sensitivity brain MRI for detecting enhancing lesions patients MS. obtained T<sub>1-weighted</sub> scans two sessions 22 clinically definite In first session, we one scan 5 to 7 minutes after injection 0.1 mmol/kg (standard dose). second 6 24 hours later, before and (for all patients) hour 11 0.3 (triple detected 83 14 when standard was used. The numbers increased 138 (average...
We assessed the pattern of regional white matter and grey abnormalities in patients with cluster headache (CH), using tract-based spatial statistics (TBSS) voxel-based morphometry (VBM).Using a 3.0 Tesla scanner, dual-echo, diffusion tensor 3D T1-weighted scan were acquired from 15 episodic CH 19 healthy controls. TBSS analysis was performed FMRIB's Diffusion Toolbox. VBM on images SPM8.No diffusivity volumetry brain detected patients. Compared controls, showed decreased volume right...
Association between migraine and vertigo has been widely studied during the last years. A central or peripheral vestibular damage may occur in patients with migrainous vertigo. Despite much evidence, at present International Headache Society classification does not include a specific category for vertigo.To assess prevalence of disorders postural abnormalities diagnosed as affected by definite according to Neuhauser.Thirty acute lasting from minutes hours underwent full otoneurological...