A5058739159- Liver Disease Diagnosis and Treatment
- Hernia repair and management
- Pelvic and Acetabular Injuries
- Diet, Metabolism, and Disease
- Folate and B Vitamins Research
- Stoma care and complications
- Colorectal and Anal Carcinomas
- Medical History and Innovations
- Bone health and osteoporosis research
- Metabolism and Genetic Disorders
- Bone health and treatments
- Innovations in Medical Education
- Health and Medical Education
- Cancer Research and Treatments
- Social Media in Health Education
- Intestinal and Peritoneal Adhesions
- Journalism and Media Studies
- Nursing care and research
- Pleural and Pulmonary Diseases
- Sports injuries and prevention
- Inflammatory mediators and NSAID effects
- Abdominal Surgery and Complications
- Bone Metabolism and Diseases
- NF-κB Signaling Pathways
- Diet and metabolism studies
Universidad de Alcalá
2003-2024
Hospital Universitario Príncipe de Asturias
1996-2023
Houston Institute for Clinical Research
2023
Hospitales Nisa
2012
Instituto de Investigaciones Biomédicas Sols-Morreale
2008
Universidad Autónoma de Madrid
2008
Hospital Universitario Fundación Jiménez Díaz
1988
We have measured the activity S -adenosyl-L-methio-nine synthetase in liver biopsies from a group of controls (n = 17) and 26 cirrhotics (12 alcoholic 14 posthepatitic). The this enzyme was markedly reduced (285 ± 32 pmoles per min mg protein) when compared with that observed (505 37 protein). No differences -adenosyl-L-methionine between both groups cirrhotics. Similarly, marked reduction phospholipid methyltransferase also same (105 12 control subjects (241 13 Again, no difference These...
We have measured the activity of S -adenosyl-L-methionine synthetase, ratio between high- and low-molecular-weight forms this enzyme concentration in liver biopsies from a group controls (n = 6) six cirrhotics (five posthepatitic one alcoholic). The total synthetase was markedly reduced cirrhosis (37.5% that found control group). This due to specific reduction high-molecular-weight (73.9 pmoles per min mg protein) when compared with observed (460.3 protein). Despite rate synthesis (the form...
Early identification of those with NAFLD activity score ≥ 4 and significant fibrosis (≥F2) or at-risk metabolic dysfunction-associated steatohepatitis (MASH) is a priority as these patients are at increased risk for disease progression may benefit from therapies. We developed validated highly specific metabolomics-driven to identify MASH.
Hepatic fibrosis is a global health problem currently without effective therapeutic approaches. Even though the ubiquitin-like posttranslational modification of neddylation, that conjugates Nedd8 (neural precursor cell expressed developmentally downregulated) to specific targets, aberrant in many pathologies, its relevance liver (LF) remained unexplored. Our results show deregulated neddylation clinical and both mouse bileductligation- CCl4 -induced fibrosis. Importantly, inhibition, by...
Non-alcoholic fatty liver disease (NAFLD) is an important cause of chronic injury that has gained concern in clinical hepatology. The principal aim this study was to find differences protein expression between patients with NAFLD and healthy controls.Changes samples from each the three groups subjects, controls, non-alcoholic steatosis, steatohepatitis (NASH), were analyzed by DIGE combined MALDI TOF/TOF analysis, a proteomic approach allows compare hundreds proteins...
BACKGROUND This study examined the prognostic information regarding risk of postoperative tumor recurrence obtained by simultaneous determination preoperative serum carcinoembryonic antigen (CEA) and immunohistochemical expression p53 protein in tissue from patients with colorectal carcinoma. METHODS A retrospective 174 (AJCC/UICC Stages I, II III) was conducted. Serum CEA levels were determined an enzyme-linked immunoadsorbent assay. Immunohistochemical nuclear assessed formalin fixed,...
This study examined the prognostic information regarding risk of postoperative tumor recurrence obtained by simultaneous determination preoperative serum carcinoembryonic antigen (CEA) and immunohistochemical expression p53 protein in tissue from patients with colorectal carcinoma.A retrospective 174 (AJCC/UICC Stages I, II III) was conducted. Serum CEA levels were determined an enzyme-linked immunoadsorbent assay. Immunohistochemical nuclear assessed formalin fixed, paraffin embedded...