A5076528771- Dialysis and Renal Disease Management
- Muscle metabolism and nutrition
- Adrenal Hormones and Disorders
- Metabolism and Genetic Disorders
- Hormonal and reproductive studies
- Gastrointestinal Tumor Research and Treatment
- Pluripotent Stem Cells Research
- Adipose Tissue and Metabolism
- Electrolyte and hormonal disorders
- Muscle and Compartmental Disorders
- Amino Acid Enzymes and Metabolism
- LGBTQ Health, Identity, and Policy
- Pharmacology and Obesity Treatment
- Colorectal Cancer Treatments and Studies
- Mitochondrial Function and Pathology
- Gastrointestinal disorders and treatments
- Physical Education and Pedagogy
- Martial Arts: Techniques, Psychology, and Education
- Alkaline Phosphatase Research Studies
- CRISPR and Genetic Engineering
- Diabetes and associated disorders
- Metastasis and carcinoma case studies
- RNA Research and Splicing
- Pharmacological Effects and Toxicity Studies
- Pleural and Pulmonary Diseases
University of Algarve
2024
Centro Nacional de Biotecnología
2017-2024
Universidad Autónoma de Madrid
2019-2024
Consejo Superior de Investigaciones Científicas
2024
Hospital Universitario Príncipe de Asturias
1995-2023
Universidad de Murcia
2022
William Harvey Research Institute
2021
Queen Mary University of London
2021
Hospital Clínic de Barcelona
2008
Hospital Universitario Miguel Servet
2008
Novel species of fungi described in this study include those from various countries as follows:
Abstract Background Treatment with glucocorticosteroids causes a negative nitrogen balance, but the kinetic mechanisms responsible for this catabolic effect are controversial. We investigated effects of 60 mg day −1 prednisolone on protein synthesis and degradation in human skeletal muscle. Materials methods Healthy adults ( n = 9) were studied postabsorptive state, before after 3 days treatment. The L‐[ring 2,6 ‐3 H 5 ]‐phenylalanine tracer technique, concentration size distribution...
The effect of blood pressure reduction on the progression rate chronic renal failure (CRF) was studied in 28 patients with CRF diverse aetiology entering a prospective study (observation time 7-24 months, mean 16 months). Endogenous creatinine clearance 12-66 ml/min (mean 30 +/- 3 ml/min). We aimed to keep below 160/90 mmHg. Dietary protein not restricted. assessed from regression coefficients regressions and inverse s-creatinine, respectively, time. Progression means all recordings arterial...
Transition from symmetric to asymmetric cell division requires precise coordination of differential gene expression. We show that embryonic stem cells (ESCs) mainly express DIDO3 and their differentiation after leukemia inhibitory factor withdrawal DIDO1 C-terminal truncation (Dido3ΔCT) impedes ESC while retaining self-renewal; small hairpin RNA-Dido1 ESCs have the same phenotype. Dido3ΔCT is rescued by ectopic expression DIDO3, which binds Dido locus via H3K4me3 RNA POL II induces DIDO1,...
Alternative splicing is facilitated by accessory proteins that guide spliceosome subunits to the primary transcript. Many of these factors recognize RNA polymerase II tail, but SFPQ a notable exception even though essential for mammalian processing. This study reveals novel role Dido3, one three Dido gene products, in alternative splicing. Binding Dido3 amino terminus histones and jaw domain was previously reported, here we show interaction between its carboxy SFPQ. We generated mutant...
The prevalence of overweight and obesity continues to rise in the population worldwide. Because it is an important predisposing factor for cancer, cardiovascular diseases, diabetes mellitus, COVID-19, reduces life expectancy. Adipose tissue (AT), main fat storage organ with endocrine capacity, plays fundamental roles systemic metabolism obesity-related diseases. Dysfunctional AT can induce excess or reduced body (lipodystrophy).
The analgesic effect and the occurrence of local reactions after repeated application a lidocaine/prilocaine cream (EMLA 5%) were investigated in 31 haemodialysis patients. was used for alleviation cannulation pain prior to (HD) period 1–1.5 years. In each patient 300 312 applications made during period. Local skin recorded evaluated with double-blind, crossover placebo controls at regular intervals. Seventeen patients completed study. EMLA gave considerable relief significantly better than...
Embryonic stem cell (ESC) differentiation and somatic reprogramming are biological processes governed by antagonistic expression or repression of a largely common set genes. Accurate regulation gene is thus essential for both processes, alterations in RNA processing predicted to negatively affect both. We show that truncation the DIDO alters splicing transcription termination ESC mouse embryo fibroblasts (MEF), which affects genes involved reprogramming. combined transcriptomic, protein...
Objectives Despite progress made in the medical field to address health concerns of sexual and gender minoritized identities, LGBTQIA+ individuals continue experience discrimination healthcare. This study aims evaluate effects incorporating a seminar on identity orientation into curriculum Portuguese Medical School, after 5 years. The study's main objective was compare changes students' knowledge, attitudes, comfort, perception against LGBTQIA+, pre post-intervention.
Urinary excretion of 3-methylhistidine has been proposed as an index internal protein breakdown provided that the intake exogenous (meat) is excluded. To evaluate potential use in metabolic assessment patients with advanced renal failure, we studied a group 11 markedly reduced function who were put on meat-free diet (the was kept constant). Steady-state plasma concentration and urinary not achieved until 14 d after exclusion meat from diet. At time had decreased by 43% 60%, respectively. We...
In microdialysis, samples from the extracellular fluid are analysed in outgoing dialysate. By adding ethanol to ingoing perfusate and following its exchange dialysate, an outflow/inflow ratio is obtained. This has been shown correlate with tissue blood flow. An automatic luminometric assay that quantifies light produced three coupled enzyme reactions described. Alcohol dehydrogenase catalyses oxidation of formation NADH, which monitored using NADH : FMN oxidoreductase bacterial luciferase....
10047 Background: There are scarce and controversial findings published on KNGL series. One of the largest analyzing 26 found two distinct subsets according to immunostaining (IS): DOG1+ cases were gastric with PDGFRA mutations DOG1- or intestinal both alike usually wild type. We analyzed expression genes known be implicated in GIST as well miRNA221/222 (negative regulators KIT) attempt a better characterization assess their prognostic value series 32 patients. Methods: The level KIT,...
In 44 adult patients, 16 men and 28 women, with chronic renal failure who were dialysed under uniform conditions (Dialyser area 1.2 m2, blood flow 200 ml/min, dialysate 500 dialysis fluid acetate concentration 35 mmol/l) we determined the plasma after 1 h of haemodialysis (1H-Ac) 3 (3H-Ac). 1H-Ac was significantly lower than 3H-Ac in both male female mean values greater males females. showed a negative correlation body surface area, serum creatinine before dialysis, albumin, respectively....