A5085801402- Single-cell and spatial transcriptomics
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Optimization and Search Problems
- RNA Research and Splicing
- MicroRNA in disease regulation
- Legume Nitrogen Fixing Symbiosis
- Auction Theory and Applications
- RNA modifications and cancer
- Gene expression and cancer classification
- Consumer Market Behavior and Pricing
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Plant nutrient uptake and metabolism
- Plant-Microbe Interactions and Immunity
- Cancer-related Molecular Pathways
- Soybean genetics and cultivation
- Machine Learning in Healthcare
- PI3K/AKT/mTOR signaling in cancer
- Hydrology and Watershed Management Studies
- Digital Media Forensic Detection
- Chaos-based Image/Signal Encryption
- Genetic Syndromes and Imprinting
Shanghai Institute of Materia Medica
2025
University of Michigan
2024-2025
University of Chinese Academy of Sciences
2025
Zhejiang University
2025
Shanxi Medical University
2025
Jilin University
2025
Sichuan Agricultural University
2024
Fujian Agriculture and Forestry University
2021-2023
Emory University
2021-2023
Shenzhen Second People's Hospital
2023
Denervation induces skeletal muscle atrophy, accompanied by complex biochemical and physiological changes, with potentially devastating outcomes even an increased mortality. Currently, however, there remains a paucity of effective strategies to treat atrophy. Therefore, it is required understand the molecular mechanisms atrophy formulate new treatment strategies. In this study, we investigated transcriptional profile denervated after peripheral nerve injury in rats. The cDNA microarray...
Cancer stem cells (CSCs) are believed to be the main source of cancer relapse and metastasis. PIWI-interacting small non-coding RNAs (piRNAs) have been recently recognized relevant biology. Whether how piRNAs regulate human CSCs remain unknown. Herein, upregulation piR-823 was identified in tested luminal breast cells, especially subtype CSCs. Enforced expression or targeted knockdown demonstrated its oncogenic function regulating cell proliferation colony formation MCF-7 T-47D cells. In...
Root-associated microbes are critical for plant growth and nutrient acquisition. However, scant information exists on optimizing communities of beneficial root-associated or the mechanisms underlying their interactions with host plants. In this report, we demonstrate that influencers Three synthetic (SynComs) were constructed based functional screening 1,893 microbial strains isolated from compartments soybean Functional assemblage SynComs promoted significant acquisition under both N/P...
Computational cell type identification is a fundamental step in single-cell omics data analysis. Supervised celltyping methods have gained increasing popularity RNA-seq because of the superior performance and availability high-quality reference datasets. Recent technological advances profiling chromatin accessibility at resolution (scATAC-seq) brought new insights to understanding epigenetic heterogeneity. With continuous accumulation scATAC-seq datasets, supervised method specifically...
Abstract Background Cell-free DNA (cfDNA) in plasma carries epigenetic signatures specific to tissue or cell of origin. Aberrant methylation patterns circulating cfDNA have emerged as valuable tools for noninvasive cancer detection, prenatal diagnostics, and organ transplant assessment. Such changes also hold significant promise the diagnosis neurodegenerative diseases, which often progresses slowly has a lengthy asymptomatic period. However, genome-wide diseases remain poorly understood....
Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy. Oxidative stress inflammation are two main molecular mechanisms involved in atrophy. In the current study, we want to explore whether how salidroside, with antioxidant anti-inflammatory properties, protects against skeletal induced by denervation. First, oxidative inflammatory response were examined during myotube nutrition deprivation. The results demonstrated cultured myotubes suffered from...
Psoriasis is a chronic skin disorder that manifests as epidermal keratinocyte hyperplasia. We examined the effect of oxymatrine treatment on cell proliferation and apoptosis in lesions psoriasis. Patients with severe plaque psoriasis were treated or acitretin. The stained proliferating nuclear antigen (PCNA), Ki‐67 Bcl‐2, well by terminal deoxynucleotidyl transferase‐mediated dUTP nick‐end labelling (TUNEL). performed correlations Area Severity Index (PASI) index. Oxymatrine significantly...
Abstract Chinese classical gardens, an essential part of World Cultural Heritage, are well exemplified by Xishu Garden as a notable branch this tradition. This research focuses on the San Su Shrine—a quintessential example Garden—and explores application digital technologies in commemorative and quantitative preservation these gardens. By integrating terrestrial laser scanning photogrammetry, we acquired data constructed models to innovate upon methodological approach garden conservation....
Considering the installation cost and coverage, received signal strength indicator (RSSI)-based indoor positioning system is widely used across world. However, performance, due to interference of wireless signals that are caused by complex environment includes a crowded population, cannot achieve demands location-based services. In this paper, we focus on increasing estimation accuracy considering population density, which different other RSSI-based methods. Therefore, propose new...
Abstract Background Cell type identification is one of the most important questions in single-cell RNA sequencing (scRNA-seq) data analysis. With accumulation public scRNA-seq data, supervised cell methods have gained increasing popularity due to better accuracy, robustness, and computational performance. Despite all advantages, performance relies heavily on several key factors: feature selection, prediction method, and, importantly, choice reference dataset. Results In this work, we perform...
Motivated by the problem of optimizing allocation in guaranteed display advertising, we develop an efficient, lightweight method generating a compact plan that can be used to guide ad server decisions. The itself uses just O(1) state per contract, is robust noise, and allows us serve (provably) nearly optimally.
Abstract Challenges in the development of anti-cancer chemotherapeutics continue to exist, particularly with respect adverse effects and resistance, underlining need for novel drugs good safety profiles. Natural products have proven be a fertile ground exploitation, from structurally complex natural holds promise. Unfortunately, this approach is often hindered by low isolation yields limited information preliminary cell-based assays. Here we report concise scalable synthesis series...
Abstract Background Dioscorea opposita Thunb, as a dual-purpose edible plant with excellent nutritional and medical value, accumulates abundant bioactive compounds, including polysaccharides. Polysaccharides from D. have been widely recognized studied due to various biological activities, such anti-inflammatory anti-cancer, which are influenced by their complex structures. In recent years, numerous studies investigated the structures activities of polysaccharides, relationships between them....
Acute myeloid leukemia (AML) is the most common subtype of hematological malignancy in humans, and its incidence increases with age. The treatment AML still faces challenges. Therefore, there an urgent need to develop more effective targeted therapies. receptor tyrosine kinase C-KIT confers critical proliferative signals AML. Cancerous inhibitor protein phosphatase 2A (CIP2A) endogenous (PP2A), which promotes growth transformation various solid tumors. These actions make CIP2A a promising...
The elevated Cyclin B1 expression contributes to various tumorigenesis and poor prognosis. could be regulated by ubiquitination deubiquitination. However, the mechanism of how is deubiquitinated its roles in human glioma remain unclear.Co-immunoprecipitation other assays were performed detect interacting USP39. A series vitro vivo experiments investigate effect USP39 on tumorigenicity tumor cells.USP39 interacts with stabilizes deubiquitinating B1. Notably, cleaves K29-linked polyubiquitin...
Abstract Detecting cell-cell communications (CCCs) in single-cell transcriptomics studies is fundamental for understanding the function of multicellular organisms. Here, we introduce FastCCC, a permutation-free framework that enables scalable, robust, and reference-based analysis identifying critical CCCs uncovering biological insights. FastCCC relies on fast Fourier transformation-based convolution to compute p -values analytically without permutations, introduces modular algebraic...