A5007136526- Autophagy in Disease and Therapy
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- HIV Research and Treatment
- Neurological Disorders and Treatments
- Retinal Imaging and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Cannabis and Cannabinoid Research
- Pain Mechanisms and Treatments
- Essential Oils and Antimicrobial Activity
- Neuroscience and Neuropharmacology Research
- Calpain Protease Function and Regulation
- RNA Interference and Gene Delivery
- Phytochemicals and Antioxidant Activities
- interferon and immune responses
- Nerve injury and regeneration
- Protease and Inhibitor Mechanisms
- Endodontics and Root Canal Treatments
- Biochemical effects in animals
- Flavonoids in Medical Research
- Retinal and Optic Conditions
- RNA Research and Splicing
- Toxoplasma gondii Research Studies
- Heart Rate Variability and Autonomic Control
University of Calabria
2015-2024
Deleted Institution
2017-2019
National Research Council
2018-2019
Ospedale dei Pellegrini
2017
University of Foggia
2012-2016
Istituto di Biologia e Biotecnologia Agraria
2016
National Academies of Sciences, Engineering, and Medicine
2014-2015
Sanford Burnham Prebys Medical Discovery Institute
2007-2014
University of Palermo
2010-2014
Magna Graecia University
2003-2010
Autophagy is the major intracellular degradation pathway that regulates long-lived proteins and organelles turnover. This process occurs at basal levels in all cells but it rapidly upregulated response to starvation cellular stress. Although being recently implicated neurodegeneration, remains still unclear whether autophagy has a detrimental or protective role. In this study, we investigated dynamics of autophagic retinal tissue undergone transient ischemia, an experimental model...
Plant extracts are a rich source of natural compounds with antimicrobial properties, which able to prevent, at some extent, the growth foodborne pathogens. The aim this study was investigate potential polyphenolic from cladodes Opuntia ficus-indica (L.) Mill. inhibit enterobacteria and biofilm formation by Staphylococcus aureus. two stages development were analysed for total phenolic content antioxidant activity Oxygen Radical Absorbance Capacity (ORAC) Trolox equivalent capacity (TEAC) (in...
Abstract Autophagy, the cellular process responsible for degradation and recycling of cytoplasmic components through autophagosomal–lysosomal pathway, is fundamental neuronal homeostasis its deregulation has been identified as a hallmark neurodegeneration. Retinal hypoxic–ischemic events occur in several sight-treating disorders, such central retinal artery occlusion, diabetic retinopathy, glaucoma, leading to degeneration loss ganglion cells. Here we analyzed autophagic response retinas...
Autophagy is an intracellular membrane trafficking pathway controlling the delivery of cytoplasmic material to lysosomes for degradation. It plays important role in cell homeostasis both normal settings and abnormal, stressful conditions. now recognised that imbalance autophagic process can impact basal functions this has recently been implicated several human diseases, including neurodegeneration cancer. Here, we investigated consequences nerve injury on a commonly used model neuropathic...
Abstract The aim of this study was to verify the activation details and products human lymphomonocytes, stimulated by different β ‐glucans, that is Euglena paramylon, MacroGard ® , lipopolysaccharide. We investigated gene expression inflammation‐related cytokines mediators, transactivation relevant transcription factors, phagocytosis role in cell‐glucan interactions, means RT ‐ PCR immunocytochemistry, colorimetric assay. Our results show sonicated alkalized paramylon upregulates...
Abstract The innate immune system has been implicated in several neurodegenerative diseases, including HIV-1–associated dementia. In this study, we show that genetic ablation of CCR5 prevents microglial activation and neuronal damage a transgenic model HIV-associated brain injury induced by CXCR4-using viral envelope gp120. knockout (KO) also rescues spatial learning memory gp120-transgenic mice. However, the CCR5KO does not abrogate astrocytosis, indicating it can occur independently from...
The effects of bergamot essential oil (BEO; Citrus bergamia, Risso) on excitotoxic neuronal damage was investigated in vitro.The study performed human SH-SY5Y neuroblastoma cells exposed to N-methyl-D-aspartate (NMDA). Cell viability measured by dye exclusion. Reactive oxygen species (ROS) and caspase-3 activity were fluorimetrically. Calpain I the activation (phosphorylation) Akt glycogen synthase kinase-3beta (GSK-3beta) assayed Western blotting.NMDA induced concentration-dependent,...
Autophagy is a homeostatic degradative process essential for basal turnover of long-lived proteins and organelles as well removal dysfunctional cellular components. Dysregulation the autophagic machinery has been recently associated to several conditions including neurodegenerative diseases cancer, but only very few studies have investigated its role in pain processing.We previously described autophagy impairment at spinal cord experimental model neuropathic induced by nerve ligation (SNL)....
Bergamot (Citrus bergamia, Risso et Poiteau) essential oil (BEO) is a well characterized, widely used plant extract. BEO exerts anxiolytic, analgesic and neuroprotective activities in rodents through mechanisms that are only partly known need to be further investigated. To gain more insight into the biological effects of this oil, we tested ability (0.005–0.03%) modulate autophagic pathways human SH-SY5Y neuroblastoma cells. BEO-treated cells show increased LC3II levels appearance dot-like...
Dementia is one of the most common causes disability worldwide characterized by memory loss, cognitive impairment, and behavioral psychological symptoms (BPSD), including agitation. Treatment latter consists off-label use harmful atypical antipsychotics, though a significant reduction afforded pain control. The an essential oil endowed with analgesic properties devoid toxicity would represent important option for management agitation in dementia. Therefore, aim this study was to engineer...
Autophagy is a catabolic self-degradative pathway that promotes the degradation and recycling of intracellular material through lysosomal compartment. Although first believed to function in conditions nutritional stress, autophagy emerging as critical cellular pathway, involved variety physiological pathophysiological processes. dysregulation associated with an increasing number diseases, including ocular diseases. On one hand, mutations autophagy-related genes have been linked cataracts,...