A5024036513- Pain Mechanisms and Treatments
- Glaucoma and retinal disorders
- Olfactory and Sensory Function Studies
- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Essential Oils and Antimicrobial Activity
- Neuropeptides and Animal Physiology
- Retinal Diseases and Treatments
- Neurological Disorders and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Autophagy in Disease and Therapy
- Medicinal Plants and Neuroprotection
- Pharmacological Receptor Mechanisms and Effects
- Cannabis and Cannabinoid Research
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and Wakefulness Research
- Coenzyme Q10 studies and effects
- Retinopathy of Prematurity Studies
- Ion channel regulation and function
- Pain Management and Opioid Use
- Pharmacological Effects of Natural Compounds
- Retinal Imaging and Analysis
- Neurological Disease Mechanisms and Treatments
- Calpain Protease Function and Regulation
University of Calabria
2015-2024
Osservatorio Astrofisico di Catania
2023
Universitat de Barcelona
2015
Sapienza University of Rome
1989-1996
Veterans Health Administration
1996
Istituto di Farmacologia Traslazionale
1992-1994
Institute of Pharmacology
1993
Autophagy is the major intracellular degradation pathway that regulates long-lived proteins and organelles turnover. This process occurs at basal levels in all cells but it rapidly upregulated response to starvation cellular stress. Although being recently implicated neurodegeneration, remains still unclear whether autophagy has a detrimental or protective role. In this study, we investigated dynamics of autophagic retinal tissue undergone transient ischemia, an experimental model...
Abstract Autophagy, the cellular process responsible for degradation and recycling of cytoplasmic components through autophagosomal–lysosomal pathway, is fundamental neuronal homeostasis its deregulation has been identified as a hallmark neurodegeneration. Retinal hypoxic–ischemic events occur in several sight-treating disorders, such central retinal artery occlusion, diabetic retinopathy, glaucoma, leading to degeneration loss ganglion cells. Here we analyzed autophagic response retinas...
purpose. To evaluate whether high intraocular pressure (IOP)–induced ischemia is associated with modifications in the retinal endocannabinoid metabolism and to ascertain drugs that interfere system may prevent damage due ischemic insult. methods. Anandamide (AEA) synthesis, transport, hydrolysis, AEA endogenous levels were assessed by means of high-performance liquid chromatography retinas rats undergoing 45 minutes followed 12 hours reperfusion. Under these experimental conditions, binding...
Preclinical studies have recently highlighted that bergamot essential oil (BEO) is endowed with remarkable neurobiolological effects. BEO can affect synaptic transmission, modulate electroencephalographic activity and it showed neuroprotective analgesic properties. The phytocomplex, along other oils, also widely used in aromatherapy to minimize symptoms of stress-induced anxiety mild mood disorders. However, only limited preclinical evidences are actually available. This study examined the...
The effects of bergamot essential oil (BEO; Citrus bergamia, Risso) on excitotoxic neuronal damage was investigated in vitro.The study performed human SH-SY5Y neuroblastoma cells exposed to N-methyl-D-aspartate (NMDA). Cell viability measured by dye exclusion. Reactive oxygen species (ROS) and caspase-3 activity were fluorimetrically. Calpain I the activation (phosphorylation) Akt glycogen synthase kinase-3beta (GSK-3beta) assayed Western blotting.NMDA induced concentration-dependent,...
Abstract Purpose Data concerning the number of diagnoses and drugs prescribed to patients affected by dementia are still scarce. Here we test whether or not (1) prescription symptomatic against Alzheimer’s disease (AD) may approximate in Italy (2) adherence this treatment affects pattern (i.e. antipsychotics antidepressants) for behavioural psychological symptoms (BPSD) previously reported limited analgesics. Methods This retrospective observational study concerns 84,235 subjects older than...
The essential oil obtained by the fresh fruit of Citrus bergamia Risso et Poiteau is used worldwide in aromatherapy to reduce pain, facilitate sleep induction, and/or minimize effects stress-induced anxiety. Preclinical pharmacological data demonstrate that bergamot (BEO) modulates specific neurotransmissions and shows an anxiolytic-relaxant effect not superimposable benzodiazepine diazepam, suggesting neurotransmissions, other than GABAergic, could be involved. Several studies on oils...
Dementia is one of the most common causes disability worldwide characterized by memory loss, cognitive impairment, and behavioral psychological symptoms (BPSD), including agitation. Treatment latter consists off-label use harmful atypical antipsychotics, though a significant reduction afforded pain control. The an essential oil endowed with analgesic properties devoid toxicity would represent important option for management agitation in dementia. Therefore, aim this study was to engineer...