A5049889996- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- CNS Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Medical Imaging Techniques and Applications
- Cytomegalovirus and herpesvirus research
- Long-Term Effects of COVID-19
- Viral-associated cancers and disorders
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Neutropenia and Cancer Infections
- Antibiotics Pharmacokinetics and Efficacy
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- Hemoglobinopathies and Related Disorders
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- HIV Research and Treatment
- Vitamin D Research Studies
- Chronic Myeloid Leukemia Treatments
- HIV-related health complications and treatments
Saarland University
2013-2025
University Medical Center
2021-2023
Universitätsklinikum des Saarlandes
2018-2021
Patients with pre-existing comorbidities and immunosuppression are at greater risk for SARS-CoV-2 infection severe manifestations of COVID-19. This also includes cancer patients, who shown to have a poor prognosis after infection. Here, we describe the case 72-year old male patient B-cell depletion maintenance treatment rituximab non-Hodgkin-lymphoma had prolonged COVID-19 course initial false negative test results. Our highlights diagnostic pitfalls in diagnosing depleted patients discuss...
from anti-inflammatory therapies such as steroids.In the work by Fadel et al, it is difficult to ascertain which was time onset of symptoms initiation steroid treatment.The fact that a large proportion patients in standard care group also received steroids makes more interpret.Based on these considerations, we suggest future studies evaluating effect immunomodulatory drugs COVID-19, moment should be considered reference for start study drug.
Fluorine-18 fluorodeoxyglucose positron emission tomography combined with computed (FDG PET/CT) is the standard for staging aggressive non-Hodgkin lymphoma (NHL). Limited data from prospective studies available to determine whether initial by FDG PET/CT provides treatment-relevant information of bone marrow (BM) involvement (BMI) and thus could spare BM biopsy (BMB).
Abstract Background In patients with iron deficiency anemia, ferric carboxymaltose (FCM) and derisomaltose (FDI) allow high-dose repletion. While FCM is reported to induce hypophosphatemia, the frequency of hypophosphatemia after an equivalent dosage FDI had not been assessed prospectively. Methods prospective, single-center, double-blind HOMe aFers study, 26 women anemia (hemoglobin < 12 g/dL plus either plasma ferritin ≤ 100 ng/mL or a 300 transferrin saturation (TSAT) 30%) were...
Platelet reconstitution after allogeneic hematopoietic cell transplantation (allo‐HCT) is heterogeneous and influenced by various patient‐ transplantation‐related factors, associated with poor prognoses for graft function (PGF) isolated thrombocytopenia. Tailored interventions could improve the outcome of patients PGF post‐HCT To provide individual predictions 180‐day platelet counts from early phase data, we developed a model long‐term allo‐HCT. A large cohort ( n = 1949) adult undergoing...
UNFOLDER (Unfavorable Young Low-Risk Densification of R-Chemo Regimens) is an international phase-3 trial in patients 18–60 years with aggressive B-cell lymphoma and intermediate prognosis defined by age-adjusted International Prognostic Index (aaIPI) 0 bulky disease (≥7.5 cm) or aaIPI 1. In a 2 × factorial design were randomized to 6× R-CHOP-14 R-CHOP-21 (rituximab, cyclophosphamide, doxorubicin, vincristine, prediso[lo]ne) consolidation radiotherapy extralymphatic observation. Response was...
The pathogenesis of autoimmune complications triggered by SARS-CoV2 has not been completely elucidated. Here, we performed an analysis the cellular immune status, cell ratios, and monocyte populations patients with COVID-19 treated in intensive care unit (ICU) (cohort 1, N = 23) normal (NCU) 2, n 10) compared control groups: ICU for noninfectious reasons 3, 30) NCU infections other than 4, 21). Patients cohort 1 presented significant differences comparison cohorts, including reduced...
Patients with diffuse large cell lymphoma who have an adequate vitamin D supply derive significantly more benefit from immuno-chemotherapy rituximab than patients deficiency; this is especially true for female patients. We already been able to show that increases the antibody-dependent cytotoxicity (ADCC) of NK cells in a sex-dependent manner, but it unclear how makes efficient. Methods: Healthy individuals deficiency were supplemented sufficient levels. isolated blood samples before and...
It has been suggested that B-cell receptor (BCRs) stimulation by specific antigens plays a pathogenic role in diffuse large lymphoma (DLBCL). Here, it was the aim to screen for reactivities of DLBCL-BCRs spectrum autoantigens and infectious origin. Arsenite resistance protein 2 (Ars2) identified as BCR target 3/5 ABC-type DLBCL cell lines 2/11 primary cases. Compared controls, Ars2 hypo-phosphorylated exclusively cases with Ars2-specific BCRs. In validation cohort, found 8/31 ABC-type, but...
Diffuse large B-cell lymphoma (DLBCL) is the most common entity, and its incidence increases with age. There a paucity of data regarding use biweekly R-CHOP (R-CHOP-14) in patients ≥80 years We performed retrospective cohort study DLBCL aged treated R-CHOP-14 R-miniCHOP two academic tertiary centers Germany between 01/01/2005 12/30/2019. Overall, 79 were included. Median age was 84 (range 80-91). Despite higher CR rates (71.4% vs. 52.4%), no statistically significant difference could be...
STRUCTURED ABSTRACT Hyperinflammation is frequently observed in patients with severe COVID-19. Inadequate and defective IFN type I responses against SARS-CoV-2, associated autoantibodies a proportion of patients, lead to courses disease. In addition, hyperactive the humoral immune system have been described. current study we investigated possible role neutralizing antiinflammatory mediators. Plasma from adult critical COVID-19 was screened by ELISA for antibodies PGRN, IL-1-Ra, IL-10,...
Objective: To identify potentially targetable psychosocial factors associated with nonadherence to prescribed antihypertensive medications in patients presenting hypertensive urgencies at an emergency department. Methods: This prospective study included treated drugs who presented (SBP ≥180 mmHg and/or DBP ≥110 mmHg) the department of a tertiary referral clinic between April 2018 and 2019. Health literacy was assessed using Newest Vital Sign test. The Hospital Anxiety Depression Scale (HADS)...
Despite numerous advances in the identification of risk factors for development severe coronavirus disease 2019 (COVID-19), that promote recovery from COVID-19 remain unknown. Natural killer (NK) cells provide innate immune defense against viral infections and are known to be activated during moderate COVID-19. Killer immunoglobulin-like receptors (KIR) mediate NK cell cytotoxicity through recognition an altered MHC-I expression on infected target cells. However, influence KIR genotype...
Not available.