A5058063005- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Birth, Development, and Health
- Biochemical Analysis and Sensing Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Neonatal and fetal brain pathology
- Diet and metabolism studies
- Immune cells in cancer
- Fatty Acid Research and Health
- Neurogenesis and neuroplasticity mechanisms
- Circadian rhythm and melatonin
- Gastrointestinal motility and disorders
- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Neurological Disease Mechanisms and Treatments
- Biochemical effects in animals
- Hypothalamic control of reproductive hormones
- Migration, Aging, and Tourism Studies
RMIT University
2016-2025
MIT University
2017-2024
RMIT Europe
2024
Australian Research Council
2021-2023
ARC Centre for Nanoscale BioPhotonics
2020-2023
University of Colorado Denver
2022
Deakin University
2021
Barwon Health
2021
Explora (Italy)
2019
Monash University
2009-2013
There are critical postnatal periods during which even subtle interventions can have long-lasting effects on adult physiology. We asked whether an immune challenge early development alter neuronal excitability and seizure susceptibility in adults. Postnatal day 14 (P14) male Sprague Dawley rats were injected with the bacterial endotoxin lipopolysaccharide (LPS), control animals received sterile saline. Three weeks later, extracellular recordings from hippocampal slices revealed enhanced...
Abstract The medial prefrontal cortex (mPFC) has been strongly implicated in control of the paraventricular nucleus hypothalamus (PVN) response to stress. Because paucity direct projections from mPFC PVN, we sought investigate possible brain regions that might act as a relay between two during psychological Bilateral ibotenic acid lesions rat enhanced number Fos‐immunoreactive cells seen PVN after exposure stressor, air puff. Altered neuronal recruitment was only one candidate populations...
The perinatal nutritional environment can permanently influence body weight, potentially leading to changes in puberty onset and reproductive function. We hypothesized that under- or overfeeding would alter concentrations of a neuropeptide crucial for successful puberty, kisspeptin. manipulated Wistar rat litter sizes derive small (SL), control (CL), large (LL) litters containing 4, 12, 20 pups respectively. This manipulation results an overweight phenotype SL rats lean LL persists...
Abstract Background Production of inflammatory mediators by reactive microglial cells in the brain is generally considered primary mechanism underlying development symptoms sickness response to systemic inflammation. Methods Depletion microglia was achieved C57BL/6 mice chronic oral administration PLX5622, a specific antagonist colony stimulating factor-1 receptor, and rats knock-in model which diphtheria toxin receptor expressed under control endogenous fractalkine (CX3CR1) promoter...
To investigate the role of endorphins in central respiratory control, effect naloxone, a specific opiate antagonist, on resting ventilation and ventilatory control was investigated randomised double-blind, placebo-controlled study normal subjects patients with chronic airways obstruction mild hypercapnia due to longstanding bronchitis. In 13 response increased after an intravenous injection naloxone (0.1 mg/kg), (VE) at PCO2 8.5 kPa increasing from 55.6 +/- SEM 6.2 75.9 8.21 min-1 (p less...