A5060041908- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Molecular Sensors and Ion Detection
- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Analytical Chemistry and Sensors
- Bacterial biofilms and quorum sensing
- Electrochemical sensors and biosensors
- Drug Transport and Resistance Mechanisms
- Maritime Transport Emissions and Efficiency
- Antibiotic Resistance in Bacteria
- Biosensors and Analytical Detection
- Graphene and Nanomaterials Applications
- Marine and Coastal Research
- Cystic Fibrosis Research Advances
- Ship Hydrodynamics and Maneuverability
- Antifungal resistance and susceptibility
- Cancer Research and Treatments
- Engineering Applied Research
- Bacterial Genetics and Biotechnology
- Cannabis and Cannabinoid Research
- Receptor Mechanisms and Signaling
- Pneumocystis jirovecii pneumonia detection and treatment
East China University of Science and Technology
2019-2024
Eastern Hepatobiliary Surgery Hospital
2024
Second Military Medical University
2024
University of Bath
2020-2024
Chinese PLA General Hospital
2024
Kunsan National University
2022-2023
Clave (Brazil)
2021
Nobel Foundation
2020-2021
Abstract Reactive oxygen species (ROS) consist of a diverse range oxidative small molecular ions and free radicals that are produced throughout the body during certain biological processes. Due to their high reactivity, these molecules result in damage tissues cells. Therefore, ROS have been implicated an array diseases including cancer, inflammation, neurodegenerative such as Parkinson's disease Alzheimer's disease. Owing simplicity, sensitivity, selectivity fluorescence‐based strategies,...
Carboxylesterases (CEs) are widely distributed in the body and catalyze hydrolysis of endogenous exogenous substrates. They play important roles drug metabolism, abnormal levels often result numerous diseases such as cancers. Therefore, it is to establish a highly selective sensitive probe for real-time sensing CEs activity. Herein, we synthesized novel fluorescence-electrochemical multichannel 1 containing ferrocene unit, which not only serves part structure but also provides...
Abstract Human beings are “machines” that use endogenously produced biomolecules as “components” in signaling and for the maintenance of body. These consist proteins, nucleic acids, carbohydrates, which can either be extracted from biological substrates or synthesized by chemical/biochemical methods. have ability to recognize/interact with other overexpressed disease cells. For targeted theranostics, strategies chemically incorporate these natural advanced materials treat human diseases...
Deferasirox, ExJade, is an FDA-approved iron chelator used for the treatment of overload. In this work, we report several fluorescent deferasirox derivatives that display unique photophysical properties, i.e., aggregation-induced emission (AIE), excited state intramolecular proton transfer, charge and through-bond through-space conjugation characteristics in aqueous media. Functionalization phenol units on scaffold afforded responsive pro-chelator ExPhos, which enabled detection...
Deferasirox, an FDA-approved iron chelator, has gained increasing attention for use in anticancer and antimicrobial applications. Recent efforts by our group led to the identification of this core as easy-to-visualize aggregation-induced emission platform, or AIEgen, that provides a therapeutic effect equivalent deferasirox (J. Am. Chem. Soc. 2021, 143, 3, 1278–1283). However, wavelength first-generation system overlapped with Syto9, green emissive dye used indicate live cells. Here, we...
Glycoconjugate-based AuNPs were developed for the targeted eradication of <italic>P. aeruginosa</italic>. This was achieved through carbohydrate-based recognition key virulence factors followed by combined therapeutic delivery and light-based treatment (PDT/PTT).
Over the past 30 years fluorescent chemosensors have evolved to incorporate many optical-based modalities and strategies. In this perspective we seek highlight current state of art as well provide our viewpoint on most significant future challenges remaining in area. To underscore trends field facilitate understanding area, reader with appropriate contemporary examples. We then conclude thoughts probable directions that chemosensor development will take not-too-distant future.
Alkaline phosphatase (ALP) is an important enzyme-based biomarker present in several bacterial species; however, it currently undervalued as a strategy to detect pathogenic bacteria. Here, we explore our ALP-responsive colorimetric and fluorescent probe (TCF-ALP) for such applications. TCF-ALP displayed fluorescence response towards Staphylococcus aureus (S. aureus), with limit of detection 3.7 × 106 CFU mL-1 after 24 h incubation. To surprise, proved selective bacteria when compared...
The ability to effectively detect bacterial infection in human tissues is important for the timely treatment of infection. However, traditional techniques fail visualize species adhered host cells situ a target-specific manner. Dihydropteroate synthase (DHPS) exclusively exists and metabolically converts p-aminobenzoic acid (PABA) folic (FA). By targeting this bacterium-specific metabolism, we have developed fluorescent imaging probe, PABA-DCM, based on conjugation PABA with long-wavelength...
We report on a superoxide anion (O 2 ˙ − ) responsive fluorescent probe called TCF-OTf.
Bacterial evolution, particularly in hospital settings, is leading to an increase multidrug resistance. Understanding the basis for this resistance critical as it can drive discovery of new antibiotics while allowing clinical use known be optimized. Here, we report a photoactive chemical probe superresolution microscopy that allows situ probing antibiotic-induced structural disruption bacteria. Conjugation between spiropyran (SP) and galactose via click chemistry produces amphiphilic...
Abstract The ester functionality is commonly seen in the areas of chemical biology and medicinal chemistry for design cell‐permeable active molecules. Ester‐based pro‐drug/pro‐sensor strategies are employed to mask polar functional groups (i. e. carboxylic acids) improve overall cell permeability these However, their use as reactive units sensing applications, including bacterial detection, has not been fully explored. Herein, we synthesised two TCF‐based fluorescent probes, TCF‐OAc TCF‐OBu...
Carboxylesterases (CEs) are involved in the biotransformation of numerous drugs, environmental toxicants, and carcinogens containing ester groups. Abnormal CEs levels associated with various diseases, as such it is widely studied cells. also characteristic biomarkers for assisting detection certain strains bacteria important biological processes. Herein, our reported two probes including an indene-chalcone-based fluorescent probe which displays green "turn-on" fluorescence response, a...
A supramolecular glycomaterial has been developed using the self-assembly of pyrenyl glycosides and graphene nanoribbon-based nanowires for targeted, photothermally-controlled release antibiotics to bacteria.
A nitroreductase (NTR) responsive fluorescent probe with long wavelength fluorescence emission was used to determine the NTR activity of a selection bacterial species under range different growth conditions.
A TCF boronate based probe developed for cellular imaging was repurposed to detect ROS in bacteria.
Recently, smart port systems connected to autonomous ships have attracted increasing interest. Thus, an intelligent system can automatically berth create system. To ensure the safety of large moored in open coastal terminals, which are often subjected bad weather such as strong winds, it is necessary calculate and evaluate their mooring security on a case-by-case basis. In this study, capacities were estimated according fishing design criteria Ministry Ocean Fisheries. Under wind speed 14...
Deferasirox, ExJade , an FDA-approved treatment for iron overload disorders has been shown to inhibit the growth of both gram-positive and -negative bacteria through (Fe(III)) chelation. Modification framework led identification a new fluorescent platform ExPh ExBT . Functionalization phenol moieties on with phosphate units afforded ratiometric pro-chelator ( ExPhos ), which was effective in inhibition two clinically relevant antibiotic-resistant bacteria, (MRSA (ATCC 43300) VRE 51299)),...