A5100351348- Spondyloarthritis Studies and Treatments
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Pharmacological Effects of Natural Compounds
- T-cell and B-cell Immunology
- Bone and Joint Diseases
- Connective tissue disorders research
- Esophageal and GI Pathology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Folate and B Vitamins Research
- Gout, Hyperuricemia, Uric Acid
- Reproductive System and Pregnancy
- Inflammatory mediators and NSAID effects
- Inflammasome and immune disorders
- Cytokine Signaling Pathways and Interactions
- Traditional Chinese Medicine Analysis
- Atherosclerosis and Cardiovascular Diseases
- Natural product bioactivities and synthesis
- Ovarian function and disorders
- Chromatography in Natural Products
Anhui University of Traditional Chinese Medicine
2022-2025
Nanjing Drum Tower Hospital
2022-2024
Nanjing University of Chinese Medicine
2020-2024
Shandong Provincial Hospital
2010-2024
Shandong First Medical University
2024
Beijing University of Chinese Medicine
2022
Sun Yat-sen University
2019-2020
Sun Yat-sen Memorial Hospital
2019-2020
Second Military Medical University
2012-2015
Changhai Hospital
2012-2015
Abstract Ankylosing spondylitis (AS) is a chronic inflammatory disease possessing morbid serum microenvironment with enhanced oxidative stress. Long-term exposure to an environment usually results in cellular senescence alone dysfunction. Mesenchymal stem cells (MSCs) are kind of cell strong capabilities for immunoregulation, and senescent MSCs may increase inflammation participate AS pathogenesis. The objective this study was explore whether how the induces MSC senescence. Here, we found...
Summary Background Many patients with chronic hepatitis B (CHB) do not meet the definitions of traditional natural phases and are classified as being in grey zone (GZ). Aims To investigate liver histology, to establish a management strategy for CHB GZ. Methods This study included 1043 who underwent biopsy. Phases history were determined according AASLD 2018 guidance. GZ divided into HBeAg‐positive, normal ALT HBV DNA ≤10 6 IU/ml (GZ‐A); elevated ≤2 × 10 4 (GZ‐B); HBeAg‐negative, ≥2 3 (GZ‐C)...
Abstract Ankylosing spondylitis (AS) is a common inflammatory autoimmune disease, characterized by pathological osteogenesis. Mesenchymal stem cells (MSCs), as the main source of osteoblasts, participate in bone remodeling not only through differentiation into osteoblasts but also indirect regulation osteoclastogenesis. Our previous study indicated that stronger osteogenic MSCs from AS patients (ASMSCs) involved However, whether there any abnormality osteoclastogenesis ASMSCs remains...
Background The relationship between serum antinuclear antibody (ANA) and rheumatoid arthritis (RA) remains unknown. Therefore, we aimed to evaluate whether ANA was associated with an increased risk of RA in a case–control study. Methods Patients hospitalized at Shandong Provincial Hospital from January 2018 December 2022 were recruited as the case group, patients other types healthy people same time taken control group. Antinuclear detected by indirect immunofluorescence assays. Propensity...
Objective. Hydroxychloroquine (HCQ) is a commonly used medicine for the treatment of systemic lupus erythematosus (SLE), and Th17 cells are closely related to pathogenesis SLE. However, role mechanism HCQ on cell differentiation in SLE not clearly understood. Here, we investigate effect both vitro patients with Methods. Twenty-five were divided into 2 groups: prednisone alone plus prednisone. Interleukin 17 (IL-17) expression was analyzed by ELISA real-time (RT)-PCR. measured flow cytometry...
Background: The upper limits of normal (ULNs) for alanine aminotransferase (ALT) are different among international guidelines chronic hepatitis B (CHB). We aimed to investigate the proportion significant histological disease in Asian patients with CHB detectable virus (HBV) DNA under diverse ALT ULNs. Methods: Consecutive and HBV who underwent liver biopsy were retrospectively included from four tertiary hospitals. Above grade 2 inflammation stage fibrosis defined as fibrosis, respectively....
Background Indices for predicting HBsAg or HBeAg seroconversion in patients with chronic hepatitis B virus (HBV) infection during antiviral therapy remain elusive.Objective We aimed to investigate if the presence of HBsAb-specific cells at baseline can predict HBV being treated peg-IFN-α nucleotide analogues (NAs).Methods 134 treatment-naive were enrolled study. collected peripheral blood mononuclear (PBMCs) from all and performed a cell ELISpot assay. Serum samples 12 weeks, 24 48 weeks...
Abstract Objectives This investigation aimed to evaluate the efficacy, key active ingredients, and mechanisms of Zuoqing San (ZQS), a traditional Chinese medicine formula, in managing sigmoid ulcerative colitis (SUC). Methods A cohort 126 participants was recruited treated with ZQS at daily dosage 100 mL for 12 weeks. The primary endpoint percentage subjects achieving favorable treatment outcomes. Liquid chromatography-mass spectrometry employed identify principal ingredients ZQS. Network...
In this study, we used microarray analysis to investigate the biogenesis and progression of intervertebral disc degeneration. The gene expression profiles 37 tissue samples obtained from patients with herniated discs degenerative disease collected by National Cancer Institute Cooperative Tissue Network were analyzed. Differentially expressed genes between more less degenerated identified significant microarray. A total 555 significantly overexpressed in a false discovery rate < 3%....
HBeAg-positive chronic hepatitis B (CHB) with low HBsAg levels represents a relatively rare serological pattern and is closely associated the severity of liver disease. However, underlying mechanisms in such cases remain largely unclear.
Abstract Background To determine the dynamic SARS-CoV-2 specific antibody levels induced by 3 doses of an inactivated COVID-19 vaccine, CoronaVac. An observational, prospective cohort study was performed with 93 healthy healthcare workers from a tertiary hospital in Nanjing, China. Serum IgM, IgG, and neutralizing antibodies (NAb) were measured at different time points among participants who received vaccine. Results 91.3% (85/93) 100% (72/72) showed positive both for IgG NAb after 2-dose...
The need for new therapeutics Ankylosing Spondylitis (AS) is highlighted by the general lack of efficacy most agents currently available this disease. Many recent studies have detailed molecular pathways in AS, and several molecule-targeting are undergoing evaluation. We aimed to explore mechanism AS identify biologically active small molecules capable targeting sub-pathways which were disregulated development AS. By using GSE25101 microarray data accessible from Gene Expression Omnibus...
We aim to investigate the potential roles of key genes in development lupus nephritis (LN), screen biomarkers, and construct lncRNA XIST/miR-381-3P/STAT1 axis by using bioinformatic prediction combined with clinical validation, thereby providing new targets insights for research.
Abstract The prompt initiation of antiviral therapy is essential in patients with chronic hepatitis B (CHB), especially when severe liver inflammation detected. However, transcutaneous puncture, the gold standard for assessing inflammation, invasive and its widespread application limited. Therefore, there an urgent need more non‐invasive markers to predict inflammation. In our retrospective cross‐sectional study, which included 120 CHB 31 healthy subjects, we observed a significant increase...
BACKGROUND:The hepatotoxicity of Tripterygium wilfordii Hook. f. (TWHF) limits its clinic utilization. Qingluo Tongbi formula (QTF) was formulated based on a basic Chinese medicine theory. Previous studies have confirmed the safety and efficacy QTF in treating rheumatoid arthritis. Therefore, we considered that TWHF could be detoxified reasonable compatibility with QTF. We investigated detoxicity mechanism reducing liver toxicity TWHF. MATERIAL AND METHODS:We used network pharmacology to...
A comprehensive bioinformatics analysis of genes which may have correlations with ankylosing spondylitis (AS).To study the mechanisms AS by analyzing microarray GSE25101.AS is an inflammatory arthritis that can lead to chronic pain and disability.GSE25101 was downloaded from Gene Expression Omnibus including 16 patients normal controls. The differentially expressed (DEGs) were screened using limma package in Bioconductor miRNAs targeted DEGs predicted. Then, gene ontology pathway enrichment...
Abstract The mechanism related to ovarian follicular is complex, which has not been fully elucidated. Abundant reports have confirmed that the function development closely sympathetic innervation. As one of major neurotransmitters, norepinephrine (NE) considered an effective regulator functions like granulosa cell (GC) apoptosis. However, between NE and GC apoptosis in rat still unclear. In our study, GCs were isolated cultured vitro with treatment. was facilitated by NE. Wilms tumor 1 (WT1)...