A5101869189- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Polyomavirus and related diseases
- Hepatitis Viruses Studies and Epidemiology
- Viral-associated cancers and disorders
- Inflammatory Biomarkers in Disease Prognosis
- COVID-19 Pandemic Impacts
- Transplantation: Methods and Outcomes
- Long-Term Effects of COVID-19
- Genital Health and Disease
- Liver Disease Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- vaccines and immunoinformatics approaches
- Liver Disease and Transplantation
- Cervical Cancer and HPV Research
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- Viral gastroenteritis research and epidemiology
- COVID-19 Impact on Reproduction
- Medical Imaging and Pathology Studies
- Infection Control in Healthcare
- Plant Virus Research Studies
- Influenza Virus Research Studies
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2013-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2009-2024
Regione Lazio
2022-2024
Tecnologie Avanzate (Italy)
2022
Center for Prevention and Treatment of Infections
2010
Vaccination is the main public health measure to reduce SARS-CoV-2 transmission and hospitalization, a massive worldwide scientific effort resulted in rapid development of effective vaccines. This work aimed define dynamics humoral cell-mediated immune response cohort care workers (HCWs) who received two-dose BNT162b2-mRNA vaccination. The serological was evaluated by quantifying anti-RBD neutralizing antibodies. performed whole blood test Th1 cytokines (IFN-γ, TNF-α, IL-2), produced spike...
Detailed temporal analyses of complete (full) blood count (CBC) parameters, their evolution and relationship to patient age, gender, co-morbidities management outcomes in survivors non-survivors with COVID-19 disease, could identify prognostic clinical biomarkers.From 29 January 2020 until 28 March 2020, we performed a longitudinal cohort study inpatients at the Italian National Institute for Infectious Diseases, Rome, Italy. 9 CBC parameters were studied as continuous variables...
Vaccine is the main public health measure to reduce SARS-CoV-2 transmission and hospitalization, a massive scientific effort worldwide resulted in rapid development of effective vaccines. This work aimed define dynamics persistence humoral cell-mediated immune response Health Care Workers who received two-dose BNT162b2-mRNA vaccination. Serological was evaluated by quantifying anti-RBD neutralizing antibodies while performed whole blood test Th1 cytokines (IFN-γ, TNF-α, IL-2) produced Spike...
The hepatitis A virus (HAV) is mainly transmitted through the faecal-oral route. In industrialized countries HAV infection generally occurs as either sporadic cases in travelers from endemic areas, local outbreak within closed/semi-closed population and foodborne community outbreak. Recently, an increasing number of clusters have been reported among young men-who-have-sex-with-men (MSM). Lazio Regional Service for epidemiology control infectious diseases (SeRESMI) has noticed increase acute...
In the setting of liver transplant (LT), survival after diagnosis de novo malignancies (DNMs) has been poorly investigated. this study, we assessed impact DNMs on LT recipients as compared to corresponding without DNM. A nested case-control study was conducted in a cohort 2,818 enrolled nine Italian centres between 1985 and 2014. Cases were 244 who developed LT. For each case, two controls matched for gender, age, year at selected by incidence density sampling among members The probabilities...
The coronavirus disease 2019 (COVID-19) emergency has represented a profound upheaval in the dynamics of infectious diseases transmission worldwide. This phenomenon been at least part driven by introduction non-pharmaceutical interventions (NPIs), implemented to counteract viral transmission. Our study aimed assess magnitude and features impact COVID-19 pandemic on incidence notifiable (NIDs) Lazio region, Italy. Data NIDs Region with symptom onset date included time interval from 1 January...
Legionnaires’ disease (LD) is an atypical pneumonia sustained by Legionella bacteria. The epidemiological LD scenario in the urban area of Rome (Italy) unique, moving from facing COVID-19 pandemic, first capital city Europe, to preparation 2025 Catholic Jubilee, starting on December 24, 2024. To provide key determinants for risk assessment setting public health and clinical preparedness activities, we analysed data cases collected Regional Lazio Surveillance Systems during 2017-2024 interval period.
This cohort study assessed, in Italy, the overall pattern of risk de novo malignancies following liver transplantation (LT). The group included 2,832 individuals who underwent LT between 1985 and 2014 nine centers all over Italy. Person–years (PYs) at cancer were computed from 30 days after to date diagnosis, death or end follow‐up. Excess risk, as compared general population, was estimated using standardized incidence ratios (SIRs) 95% confidence intervals (CIs). During 18,642 PYs, 246...
Vaccination against SARS-CoV-2 is considered the most effective method of prevention to contain pandemic. While highly vaccines are being applied on a large-scale, whether and what extent strength vaccine-induced immune response could be further potentiated still an object debate. Several reports studied effect different susceptibility mortality COVID-19, with conflicting results. We aimed evaluate previous influenza and/or pneumococcal vaccination had impact specific BNT162b2 mRNA vaccine....
Dengue virus (DENV) has been expanding its range to temperate areas that are not usually affected, where the spread of vectors facilitated by global trade and climate change. In Europe, there have many cases DENV imported from other regions in past few years, leading local outbreaks among people without travel history. Here we describe epidemiological molecular investigations three transmission events locally acquired infections caused serotypes 1, 2, 3, respectively, Latium Region August...
Background: More detailed temporal analyses of complete (Full) blood count (CBC) parameters, their evolution and relationship to patient age, gender, co-morbidities management outcomes in survivors non-survivors with COVID-19 disease could help identify prognostic clinical biomarkers. Methods: From 29 January 2020 until 28 March 2020, we performed a longitudinal cohort study inpatients at the Italian National Institute for Infectious Diseases, Rome, Italy. Nine CBC parameters as continuous...
Sharp injuries, determining the risk of bloodborne infections and psychological distress in healthcare workers, may be prevented by a set strategies, legally enforced Europe through Directive 2010/32/EU. To assess its level implementation Italy, national survey was conducted 2017 again 2021, evaluating progress possible drawbacks COVID-19 pandemic. Altogether, 285 safety managers 330 nurses from representative sample 97 117 public hospitals were interviewed using standardized questionnaire....
The waning of the protective effect COVID-19 vaccines and timing booster doses are debated.Population-based cohort study in largest Health-Authority Lazio region, Italy, on 946,156 residents aged 12+ (study period: 1 January 2021-10 2022). Vaccine effectiveness (VE) against any SARS-CoV-2 infection (symptomatic or asymptomatic) was estimated through multivariable negative-binomial models using unvaccinated person-time as a reference.The primary vaccination cycle completed by 81% residents;...
This study aims to identify the risk factors for intensive care (IC) in severe malaria patients admitted "Lazzaro Spallanzani" National Institute Infectious Diseases, Rome, Italy.All with confirmed and hospitalized between 2007 2015 were included analysis stratified into two groups: those requiring IC who did not. Five prognostic scores estimated; clinical severity at unit admission was assessed using Sequential Organ Failure Assessment quick-Sequential scores. Univariate multivariate...
This is a retrospective observational study including all COVID-19 patients admitted at our Institute throughout three successive pandemic waves, from January 2021 to June 2023. The main in-hospital outcomes (clinical progression [CP], defined as admission Intensive Care Unit [ICU]/death, and death within 28 days) were compared among participants unvaccinated (NV), fully vaccinated (FV), with one (FV&B1) two (FV&B2) booster doses. Vaccinated stratified into recently waned FV/FV&B1/FV&B2,...
<title>Abstract</title> <bold>Background</bold> The coronavirus disease 2019 (COVID-19) emergency accounted for a profound disruption in the infectious diseases’ transmission dynamics worldwide. This phenomenon was at least part driven by introduction of non-pharmaceutical interventions (NPIs), implemented to tackle viral transmission. Our study aimed assess magnitude and features impact COVID-19 pandemic on incidence notifiable diseases (NIDs) Lazio region, Italy. <bold>Methods</bold>...