A5021173892- interferon and immune responses
- Redox biology and oxidative stress
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Galectins and Cancer Biology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Mechanisms and Therapy
- RNA regulation and disease
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Circadian rhythm and melatonin
- Immunotherapy and Immune Responses
- CRISPR and Genetic Engineering
- Chromatin Remodeling and Cancer
- Influenza Virus Research Studies
- Circular RNAs in diseases
The University of Texas MD Anderson Cancer Center
2023-2024
The Wistar Institute
2022-2023
Abstract Aberrant glycosylation is a crucial strategy employed by cancer cells to evade cellular immunity. However, it’s unclear whether homologous recombination (HR) status-dependent can be therapeutically explored. Here, we show that the inhibition of branched N -glycans sensitizes HR-proficient, but not HR-deficient, epithelial ovarian cancers (EOCs) immune checkpoint blockade (ICB). In contrast fucosylation whose EOCs anti-PD-L1 immunotherapy regardless HR-status, observe an enrichment...
We have previously demonstrated that the circadian clock regulates host response to influenza A virus (IAV) infection, conferring a time-of-day-specific protection; infection at dawn resulted in threefold increase survival and reduced immunopathology compared dusk. While IL–10 is well-known for its immunoregulatory function, role IAV remains unclear, with studies reporting both protective detrimental effects. Given diurnal rhythmicity of receptor (Il10ra) expression lung, we investigated...
Abstract Introduction: Epithelial Ovarian cancer (EOC) is one of the most fatal gynecological malignancies, with little improvement being made to early-stage diagnostics or treatment options over years. The standard care for EOC remains be platinum-based chemotherapy despite ultimate relapse which arises acquired chemoresistance. Accumulating studies show that stem-like cells (CSCs) following initial platinum contribute developed chemoresistance and metastasis. Thus, there an urgent need...
Abstract Cellular senescence regulates cancer and tissue aging in part through the secretion of proinflammatory factors known as senescence-associated secretory phenotype (SASP). For example, sterile inflammation or ‘inflammaging’ is a hallmark aging. Thioredoxin reductase 1 (TXNRD1) genetic variability associated with often upregulated human cancers. TXNRD1’s role regulating has been attributed to its enzymatic cellular redox. Here we show that TXNRD1 drives SASP cyclic GMP-AMP synthase...