A5024944705- Circadian rhythm and melatonin
- Neonatal Respiratory Health Research
- Spaceflight effects on biology
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Cell Function and Interaction
- Birth, Development, and Health
- Aerospace Engineering and Energy Systems
- Influenza Virus Research Studies
- Neuroscience of respiration and sleep
Children's Hospital of Philadelphia
2020-2023
University of Pennsylvania
2021
We have previously demonstrated that the circadian clock regulates host response to influenza A virus (IAV) infection, conferring a time-of-day-specific protection; infection at dawn resulted in threefold increase survival and reduced immunopathology compared dusk. While IL–10 is well-known for its immunoregulatory function, role IAV remains unclear, with studies reporting both protective detrimental effects. Given diurnal rhythmicity of receptor (Il10ra) expression lung, we investigated...
Adverse early-life exposures have a lasting negative impact on health. Neonatal hyperoxia that is risk factor for bronchopulmonary dysplasia confers susceptibility to influenza A virus (IAV) infection later in life. Given our previous findings the circadian clock protects against IAV, we asked if long-term of neonatal vis-à-vis IAV includes disruption. Here, show abolishes clock-mediated time day protection from mice, independent viral burden through host tolerance pathways. We discovered...
Optimal lung repair and regeneration are essential for recovery from viral infections, including influenza A virus (IAV). We have previously demonstrated that acute inflammation mortality induced by IAV is under circadian control. However, it not known whether the influence of clock persists beyond outcomes. Here, we utilize UK Biobank to demonstrate an association between poor rhythms morbidity lower respiratory tract need hospitalization after discharge; this even adjusting common...
Circadian rhythms refer to oscillations in various biological process that occur with a 24 h period. At the molecular level, such are comprised of web transcriptional-translational feedback loops (TTFL) core clock genes. Individual tissues and organ systems, including immune system, have their own clock. In systemic circulation, members CD45+ population oscillate across day; however, many these not identical or even similar tissue resident leukocyte population. When studying role circadian...
Abstract Optimal lung repair and regeneration is essential for recovery from viral infections such as that induced by influenza A virus (IAV). We have previously demonstrated inflammation IAV under circadian control. However, it not known if the clock exerts its influence on regenerative processes independent of acute IAV. Here, we demonstrate first time organoids a functional they mature absence an intact impairs capacity. Using several models disruption, show with proliferation disrupted....
Abstract Circadian rhythms form an anticipatory system wherein various aspects of cellular physiology oscillate across a 24hrs period; these have been known to modulate facets immunity. We previously shown that mice infected with Influenza A virus (IAV) at dusk had 3-fold higher mortality than littermates dawn--a hallmark circadian regulation. This time-of-day specific protection was lost when NK cells were depleted just before the infection, suggesting role in mediating regulation IAV...
Abstract Adverse early life exposures having a lasting negative impact on health. For examples, neonatal hyperoxia which is risk factor for chronic lung disease of prematurity or bronchopulmonary dysplasia (BPD) confers susceptibility to respiratory infections like Influenza A (IAV) later in life. Given our previous findings that the circadian clock exerts protective effect injury from IAV, we asked if long-term includes disruption rhythms. We show here abolishes mediated time day protection...
Circadian rhythms refer to oscillations in various biological process that occur with a 24 h period. At the molecular level, such are comprised of web transcriptional-translational feedback loops (TTFL) core clock genes. Individual tissues and organ systems, including immune system, have their own clock. In systemic circulation, members CD45+ population oscillate across day; however, many these not identical or even similar tissue resident leukocyte population. When studying role circadian...
Abstract Influenza is a leading cause of respiratory mortality and morbidity. While inflammation necessary for fighting influenza, fine balance anti-viral defense host tolerance crucial to successful recovery from the same. Circadian rhythms form an anticipatory system wherein various aspects cellular physiology oscillate across 24hrs period; these have been known modulate facets immunity. We recently demonstrated that circadian control lung injury in influenza A virus (IAV) infection....