A5025161921- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Inflammatory mediators and NSAID effects
- Cancer Cells and Metastasis
- Genomics, phytochemicals, and oxidative stress
- Colorectal Cancer Treatments and Studies
- Medicinal Plants and Bioactive Compounds
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Ginseng Biological Effects and Applications
- Adipose Tissue and Metabolism
- Pharmacological Effects of Natural Compounds
- Biochemical effects in animals
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer-related gene regulation
- Urologic and reproductive health conditions
- Ubiquitin and proteasome pathways
- Prostate Cancer Treatment and Research
- Pharmacological Effects of Medicinal Plants
- Exercise and Physiological Responses
- Testicular diseases and treatments
- Antimicrobial Peptides and Activities
- TGF-β signaling in diseases
Iranian Legal Medicine Organization
2018-2024
Academic Center for Education, Culture and Research
2017-2022
Royan Institute
2017-2022
Isfahan University of Medical Sciences
2021-2022
University of Liverpool
2013-2020
Shahid Beheshti University of Medical Sciences
2019
In previous work, it is suggested that the excessive amount of fatty acids transported by FABP5 may facilitate malignant progression prostate cancer cells through a FABP5-PPARγ-VEGF signal transduction axis to increase angiogenesis. To further functionally characterise pathway, we have, in this investigated molecular mechanisms involved its tumorigenicity promoting role cancer. Suppression PPARγ highly produced significant reduction (up 53%) their proliferation rate, invasiveness 89%) and...
The purpose of this study was to test the hypothesis that cooperative interaction between cutaneous fatty acid-binding protein (C-FABP) and peroxisome proliferator-activated receptors (PPAR) promotes malignant progression human prostate cancer. expression C-FABP, PPARβ/δ PPARγ measured by western blot analysis in cell lines immunohistochemical staining tissue sections benign prostatic hyperplasia (BPH) carcinomas. correlation PPARs C-FABP assessed. significance increased these proteins...
Cutaneous fatty acid–binding protein (C-FABP), a cancer promoter and metastasis inducer, is overexpressed in the majority of prostatic carcinomas. Investigation molecular mechanisms involved tumor-promoting activity C-FABP has established that there acid–initiated signaling pathway leading to malignant progression cells. Increased expression plays an important role this novel pathway. Thus, when increased, excessive amounts acids are transported into nucleus where they act as molecules...
Stemness phenotype mammospheres established from cell lines and tissues taken autopsy can be used to test identify the most sensitive drugs for chemotherapy. Therefore, aim of present study was isolation characterization cancer stem cells derived MCF7, MDA-MB231, SKBR3 breast demonstrate stemness phenotypes generated further their applications in therapeutic approaches. In this study, two luminal subtypes lines, MCF7 a basal subtype line, MDA-MB-231, were chosen. Mammosphere culturing...
// Waseem Al-Jameel 1 , Xiaojun Gou 2 Shiva S. Forootan Majed Saad Al Fayi Philip Rudland 3 Farzad Jiacheng Zhang A. Cornford Syed Hussain Youqiang Ke Molecular Pathology Laboratory, Department of and Clinical Cancer Medicine, Liverpool University, Liverpool, L3 9TA, United Kingdom Sichuan Antibiotics Industrial Institute, Chengdu 610081, China Biochemistry, L69 3GA, Correspondence to: Ke, email: yqk@liverpool.ac.uk Keywords: SBFI26, FABP5, CRPC, PPARγ, metastasis Received: December 19, 2016...
Abstract Background SPTC is a mix of four herbal components ( Salvia officinalis , Panax ginseng Trigonella foenum-graeceum and Cinnamomum zeylanicum ) which might be prevented the development AGE rich diet-induced diabetic complication liver injury through activated nuclear factor erythroid-2-related-factor-2 (Nrf2) pathway. Nrf2, as master regulator antioxidant response elements by activating cytoprotective genes expression, decreased oxidative stress that associated with hyperglycemia...
Constant deregulation of Id1 and Id3 has been implicated in a wide range carcinomas. However, underlying molecular evidence for the joint role tumorigenicity small cell lung cancer (SCLC) is sparse. Investigating biological significance elevated expression SCLC cells, we found that co-suppression resulted significant reduction proliferation rate, invasiveness anchorage-independent growth. Suppressing both also greatly reduced average size tumors produced by transfectant cells when inoculated...
Skeletal muscle mitochondria is one of the most important affected sites T2DM and its molecular mechanism yet to be elucidated. Some recent theories believed that mitochondrial markers are upregulated in response high fat induced T2DM; however, reasons factors still uncertain. In this regard, we aimed investigate effect on skeletal muscle, an herbal component along with endurance exercise, as probable treatments, AGE-rich high-fat diet (AGEs-HFD) mice.T2DM was by 16 weeks AGEs-HFD...
BACKGROUND: Previous studies have shown that the FABP9/PERF15 gene is expressed in mice and some other mammals testicles spermatozoa, its possible effect on ability of sperm to form maintain nucleus until fertilization. OBJECTIVE: Since FABP9 homologue g ene exists humans, so far no research has been done indicate exact location this organism, it necessary find a better interpretation performance by localization testis. MATERIAL AND METHODS: Biopsied testicular tissue samples after...
Abstract Background Obesity is associated with many comorbidities including inflammatory bowel disease (IBD). We investigated prophylactic effects of an herbal extract (HE) on the DSS-induced colitis mice challenged high AGEs-fat diet 60% (HFD). Methods Six-week-old C57BL/6 male were fed either HFD (8 groups, 6 in each group), or normal (ND) group). After weeks, animals received HE (combination turmeric, ginger, boswellia and cat’s claw extract) for 7 weeks three doses (high dose (0.6 mg/g);...
Abstract Background Molecular heterogeneity is one of the most important concerns in colorectal cancer (CRC), which results a wide range therapy responses and patient prognosis. We aimed to identify genes with high expression (HHE) their relation prognosis drug resistance. Methods Two cohort studies, genome atlas (TCGA) GSE39582, were used discover oncogenes HHE. The relationship between identified clinical genomic characteristics was evaluated based on TCGA data. Also, GDSC CCLE data for...
Abstract Background: SPTC is a mix of four herbal components ( Salvia officinalis , Panax ginseng Trigonella foenum-graeceum and Cinnamomum zeylanicum ) which might be prevented the development AGE rich diet-induced diabetic complication liver injury through activated nuclear factor erythroid-2-related-factor-2 (Nrf2) pathway. Nrf2, as master regulator antioxidant response elements by activating cytoprotective genes expression, decreased oxidative stress that associated with hyperglycemia...
Introduction Breast cancer stem cells (BCSCs) have specific markers such as CD44+/ CD24-and behaviors including self-renewal, differentiation, metastasis, migration and therapy resistance.BCSCs can be enriched by culturing of in non-adherent non-differentiating circumstances.With regard to resistance CSCs, it is important enrich CSCs for more efficient which directly targets with suitable doses drugs.This study compares stemness phenotypes mammospheres generated from three breast cell...
Abstract Background: SPTC is a mix of four herbal components ( Salvia officinalis , Panax ginseng Trigonella foenum-graeceum and Cinnamomum zeylanicum ) which may prevent the development AGEs rich diet-induced diabetic complication liver injury via activating nuclear factor erythroid-2-related-factor-2 (Nrf2) pathway. Nrf2, as master regulator antioxidant response elements by cytoprotective genes expression, decreases oxidative stress associated with hyperglycemia increases insulin...