A5088496837- Computational Drug Discovery Methods
- PI3K/AKT/mTOR signaling in cancer
- Ubiquitin and proteasome pathways
- Protein Structure and Dynamics
- Protein Kinase Regulation and GTPase Signaling
- Biochemical and Molecular Research
- RNA modifications and cancer
- Chronic Lymphocytic Leukemia Research
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Protein Degradation and Inhibitors
- Pharmacogenetics and Drug Metabolism
- Cancer-related Molecular Pathways
- Cancer-related gene regulation
- Glycosylation and Glycoproteins Research
- Receptor Mechanisms and Signaling
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Enzyme Structure and Function
- DNA and Nucleic Acid Chemistry
- RNA Research and Splicing
- Cancer therapeutics and mechanisms
- Endoplasmic Reticulum Stress and Disease
- Genetics, Bioinformatics, and Biomedical Research
The University of Texas MD Anderson Cancer Center
2015-2024
Zhejiang University of Technology
2024
State Key Laboratory of Industrial Control Technology
2024
The University of Texas Health Science Center at Houston
2018-2023
Hebei University of Technology
2022
Northwestern Polytechnical University
2021
Chinese Academy of Agricultural Sciences
2021
Institute of Animal Sciences
2021
The Graduate Center, CUNY
2021
Zhengzhou University
2020
Mutations in the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) play a critical role cancer cell growth and resistance to therapy. Most mutations occur at codons 12 13. In colorectal cancer, presence of any mutant KRas amino acid substitution is negative predictor patient response targeted However, non–small lung (NSCLC), evidence that KRAS mutation predictive factor conflicting. We used data from molecularly clinical trial for 215 patients with tissues available out 268...
Bone metastases occur in 50-70% of patients with late-stage breast cancers and effective therapies are needed. The expression enhancer zeste homolog 2 (EZH2) is correlated cancer metastasis, but its function bone metastasis hasn't been well-explored. Here we report that EZH2 promotes osteolytic through regulating transforming growth factor beta (TGFβ) signaling. induces cell proliferation osteoclast maturation, whereas knockdown decreases incidence outgrowth vivo. Mechanistically,...
A novel automated lazy learning quantitative structure−activity relationship (ALL-QSAR) modeling approach has been developed on the basis of theory. The activity a test compound is predicted from locally weighted linear regression model using chemical descriptors and biological training set compounds most chemically similar to this compound. weights with which are included in depend similarity those We have applied ALL-QSAR method several experimental data sets including 48 anticonvulsant...
Rho-associated kinases (Rho kinases), which are downstream effectors of RhoA GTPase, regulate diverse cellular functions including actin cytoskeletal organization. We have demonstrated that Rho also direct the early stages chick and mouse embryonic morphogenesis. observed kinase transcripts were enriched in cardiac mesoderm, lateral plate mesoderm neural plate. Treatment neurulating embryos with Y27632, a specific inhibitor kinases, blocked migration fusion bilateral heart primordia,...
Unique insights for the reprograming of cell lineages have come from embryonic development in ascidian Ciona , which is dependent upon transcription factors Ci -ets1/2 and -mesp to generate cardiac progenitors. We tested idea that mammalian v-ets erythroblastosis virus E26 oncogene homolog 2 (ETS2) mesoderm posterior (MESP) may be used convert human dermal fibroblasts into Here we show murine ETS2 has a critical role directing progenitors during cardiopoiesis stem cells. then use...
Abstract PI3K/Akt signaling is activated in cancers and governs tumor initiation progression, but how Akt under diverse stresses poorly understood. Here we identify AMPK as an essential regulator for activation by various stresses. Surprisingly, also growth factor EGF through Ca2+/Calmodulin-dependent kinase EGF-mediated biological functions. phosphorylates Skp2 at S256 promotes the integrity E3 ligase activity of SCF complex leading to K63-linked ubiquitination subsequent oncogenic...
RNA solution for a genetic problem Phenylketonuria provides classic case of the benefit newborn metabolic screening: It is single-gene disease that can be detected at birth, and its neurological effects prevented by dietary therapy. Unfortunately, this not always straightforward because disease-causing mutations in phenylalanine hydroxylase vary between patients affect severity phenotype, such some patients’ symptoms do fully respond to available interventions. Li et al . identified two long...
The mechanisms by which human immunodeficiency virus (HIV) infection provokes progressive neurodegeneration and dementia in acquired syndrome (AIDS) remain obscure. In HIV-infected (HIV+) individuals, we found that the brain cells preferentially infected HIV, viz. microglia, were abundant, activated, intensely immunopositive for interleukin-1 alpha (IL-1 alpha), an immune response-generated cytokine increases synthesis processing of beta-amyloid precursor proteins (beta-APP) promotes...
The LKB1/AMPK pathway plays a major role in cellular homeostasis and tumor suppression. Down-regulation of occurs several human cancers has been implicated metabolic diseases. However, the precise upstream regulation LKB1-AMPK is largely unknown. Here, we report that AMPK activation by LKB1 regulated tankyrases. Tankyrases interact with ribosylate LKB1, promoting its K63-linked ubiquitination an E3 ligase RNF146, which blocks LKB1/STRAD/MO25 complex formation activation. tankyrase inhibitors...
Aptamers, synthetic single-strand oligonucleotides that are similar in function to antibodies, promising as therapeutics because of their minimal side effects. However, the stability and bioavailability aptamers pose a challenge. We developed converted from RNA aptamer modified DNA target phospho-AXL with improved bioavailability. On basis comparative analysis library 17 aptamers, we selected candidates, GLB-G25 GLB-A04, exhibited highest bioavailability, stability, robust antitumor effect...
Molecular-docking-based virtual screening is an important tool in drug discovery that used to significantly reduce the number of possible chemical compounds be investigated. In addition selection a sound docking strategy with appropriate scoring functions, another technical challenge silico screen millions reasonable time. To meet this challenge, it necessary use high performance computing (HPC) platforms and techniques. However, development integrated HPC system makes efficient its elements...
Novel geometrical chemical descriptors have been derived on the basis of computational geometry protein-ligand interfaces and Pauling atomic electronegativities (EN). Delaunay tessellation has applied to a diverse set 517 X-ray characterized complexes yielding unique collection interfacial nearest neighbor quadruplets for each complex. Each quadruplet composition was by single descriptor calculated as sum EN values four participating atom types. We termed these simple generated from with...