A5062319147- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Transplantation: Methods and Outcomes
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Muscle Physiology and Disorders
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Pregnancy and preeclampsia studies
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- Birth, Development, and Health
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Growth Hormone and Insulin-like Growth Factors
- Cardiac Fibrosis and Remodeling
- Glioma Diagnosis and Treatment
The University of Texas MD Anderson Cancer Center
2019-2025
Peking University Third Hospital
2024
Peking University
2024
Capital Medical University
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Chinese Institute for Brain Research
2022
RNA solution for a genetic problem Phenylketonuria provides classic case of the benefit newborn metabolic screening: It is single-gene disease that can be detected at birth, and its neurological effects prevented by dietary therapy. Unfortunately, this not always straightforward because disease-causing mutations in phenylalanine hydroxylase vary between patients affect severity phenotype, such some patients’ symptoms do fully respond to available interventions. Li et al . identified two long...
One of the major obstacles to treating pancreatic ductal adenocarcinoma (PDAC) is its immunoresistant microenvironment. The functional importance and molecular mechanisms Schwann cells in PDAC remains largely elusive. We characterized gene signature tumor-associated nonmyelinating (TASc) indicated that abundance TASc was correlated with immune suppressive tumor microenvironment unfavorable outcome patients PDAC. Depletion pancreatic-specific promoted tumorigenesis tumors. TASc-expressed long...
Immune checkpoint inhibitors (ICIs) have been increasingly used in combination for cancer treatment but are associated with myocarditis. Here, we report that tumor-bearing mice exhibited response to combinatorial anti–programmed cell death 1 and anti–cytotoxic T lymphocyte antigen–4 antibodies also presented cardiovascular toxicities observed clinically ICI therapy, including myocarditis arrhythmia. Female were preferentially affected compared male mice, consistent a previously described...
Hypertension is a common cardiovascular disease that related to genetic and environmental factors, but its mechanisms remain unclear. DNA methylation, classic epigenetic modification, not only regulates gene expression also susceptible linking factors modification. Therefore, globally screening differential genomic methylation in patients with hypertension important for investigating mechanisms. Differential hypertension, individuals prehypertension, healthy control was screened using...
Abstract Background Exercise training is well established as the most effective way to enhance muscle performance and building. The composition of skeletal fiber type affects systemic energy expenditures, perturbations in metabolic homeostasis contribute onset obesity other dysfunctions. Long noncoding RNAs (lncRNAs) have been demonstrated play critical roles diverse cellular processes diseases, including human cancers; however, functional importance lncRNAs performance, balance, remains...
G1, a specific agonist targeting the G protein-coupled receptor 30 (GPR30), has demonstrated significant involvement in combating obesity and regulating glucose homeostasis. Nevertheless, beneficial effects of G1 treatment have solely been investigated animal models under normal feeding conditions, leaving its therapeutic potential high-fat scenarios unexplored.
Background Gliomas, the most prevalent primary malignant tumors of central nervous system in adults, exhibit slow growth lower-grade gliomas (LGG). However, majority LGG cases progress to high-grade gliomas, posing challenges for prognostication. The tumor microenvironment (TME), characterized by telomere-related genes and immune cell infiltration, strongly influences glioma therapeutic response. Therefore, our objective was develop a Telomere-TME (TM-TME) classifier that integrates...