A5048817680- Multiple Sclerosis Research Studies
- Hepatitis Viruses Studies and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Sociology and Education Studies
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Peripheral Neuropathies and Disorders
- Wound Healing and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Protease and Inhibitor Mechanisms
- interferon and immune responses
- Viral Infections and Immunology Research
- Hidradenitis Suppurativa and Treatments
- Periodontal Regeneration and Treatments
- Social Work Education and Practice
- Ocular Diseases and Behçet’s Syndrome
- Anorectal Disease Treatments and Outcomes
- Cell death mechanisms and regulation
- Psychology, Coaching, and Therapy
- Viral gastroenteritis research and epidemiology
- Telomeres, Telomerase, and Senescence
- Rheumatoid Arthritis Research and Therapies
- Bariatric Surgery and Outcomes
- Veterinary Orthopedics and Neurology
- Neuropeptides and Animal Physiology
Universität Ulm
2025
University of Vienna
2024
University of Tübingen
1986-2022
Friedrich-Alexander-Universität Erlangen-Nürnberg
2020
Bernstein Center for Computational Neuroscience Tübingen
2019
University of Vechta
2019
Medical University of Vienna
2003
University of Göttingen
2000
University of Hohenheim
1988
Institute of Medical Microbiology and Hygiene
1986
Optic neuritis is one of the most common clinical manifestations multiple sclerosis (MS), a chronic inflammatory disease CNS. High-dosage methylprednisolone treatment has been established as standard therapy acute inflammation optic nerve (ON). The rationale for corticosteroid lies in antiinflammatory and immunosuppressive properties these drugs, shown experimental autoimmune encephalomyelitis (EAE), animal model MS. To investigate influence on survival retinal ganglion cells (RGCs), neurons...
Neuronal and axonal damage is considered to be the main cause for long‐term disability in multiple sclerosis. We analyzed mechanisms kinetics of neuronal cell death experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte glycoprotein (MOG) combining an electrophysiological vivo assessment optic pathway with investigation retinal ganglion (RGC) counts. In accordance our previous findings this animal model, neuritis nerve (ON) leads apoptotic RGC death. By further...
Neurodegenerative processes determine the clinical disease course of multiple sclerosis, an inflammatory autoimmune CNS that frequently manifests with acute optic neuritis. None established sclerosis therapies has been shown to clearly reduce neurodegeneration. In a rat model experimental encephalomyelitis, we recently demonstrated increased neuronal apoptosis under methylprednisolone therapy, although inflammation was effectively controlled. present study, combined steroid treatment...
Journal Article Liver-Derived Cytotoxic T Cells in Hepatitis A Virus Infection Get access Angelika Vallbracht, Vallbracht Please address requests for reprints to Dr. Hygiene-Institut der Universität Tübingen, Silcherstr. 7, 0-7400 FRG. Search other works by this author on: Oxford Academic PubMed Google Scholar Katharina Maier, Maier York-Dieter Stierhof, Stierhof Karl Herrmann Wiedmann, Wiedmann Bertram Flehmig, Flehmig Bernhard Fleischer The of Infectious Diseases, Volume 160, Issue 2,...
We studied cell-mediated cytotoxicity to hepatitis A virus-infected cells in seven patients with acute type and two controls. Skin fibroblast cultures obtained from the skin biopsies of after virus infection persons without history current or past were inoculated virus. Infection always resulted an inapparent, persistent production release infectious Peripheral blood lymphocytes collected same at different times onset icterus stored liquid nitrogen. Cytolytic activity peripheral was...
ABSTRACT Primary human skin fibroblasts derived from the abdomen of 45 female donors four age groups 1–20, 20–40, 40–60, and 60–80 years were studied in primary explant, low-density mass cultures, clonal populations vitro. As a function donor, mitotic postmitotic three cell systems analysed represent heterogeneous with reproducible changes proportions MF I, II, III, PMF IV, V, VI, VII. These findings make it very likely that equivalent types exist connective tissue vivo, these cells undergo...
Abstract Pilonidal sinus disease (PSD) is increasing globally. A recent meta-analysis and merged-data analysis showed that recurrence rates in PSD depend essentially on follow-up time specific surgical procedures. However, the global distribution of approaches respective have never been studied PSD. We aimed at studying impact geographic to treat subsequent geography-specific rates. searched relevant databases as described previously. Recurrence were then associated with reported times...
Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS which leads to demyelination, axonal destruction and neuronal loss in early stages. Available therapies mainly target component but fail prevent neurodegeneration. To investigate effect ciliary neurotrophic factor (CNTF) on survival retinal ganglion cells (RGCs), neurons that form axons optic nerve, we used rat model myelin oligodendrocyte glycoprotein‐induced experimental autoimmune encephalomyelitis. Optic neuritis this...
The production of interferon (IFN) during a chromium-51 release assay with hepatitis A virus (HAV)-infected fibroblasts and autologous peripheral blood lymphocytes from patients acute HAV infection was studied to determine whether IFN plays role in immunopathogenesis humans. Skin eight after two control persons without history current or past were infected HAV. Peripheral collected at different times the onset icterus tested against HAV-infected skin for their cytolytic IFN-producing...
Introduction Most trauma patients require intensive care treatment and are susceptible to developing persistent inflammation immunosuppression, potentially leading multi organ dysfunction syndrome (MODS) dependence on long term facilities. T cells undergo changes in numbers function post trauma. cell polytraumatized was characterized using functional immunomonitoring predict individual clinical outcome. Moreover, the potential reverse Interleukin (IL)-7 examined. Methods Blood samples were...
Patients with pancreatic ductal adenocarcinoma (PDAC) normally have a poor long-term prognosis. However, some rare cases of survivors been reported. The tumor microenvironment, consisting cellular and stromal components, possibly plays an important role might influence In this context, the tumor-infiltrating B-cells its impact on survival in patients PDAC remains controversial. We therefore aimed to assess prognostic value CD20-positive B-cell aggregates as well CD138, IgM, Pax5, Ki67 using...
ABSTRACT In a rabbit model of Streptococcus pneumoniae meningitis, 5 mg gemifloxacin mesylate (SB-265805) per kg/h reduced the bacterial titers in cerebrospinal fluid (CSF) almost as rapidly 10 ceftriaxone (Δlog CFU/ml/h ± standard deviation [SD], −0.25 0.09 versus −0.38 0.11; serum and CSF concentrations were 2.1 1.4 mg/liter 0.59 0.38 mg/liter, respectively, at 24 h). Coadministration 1 dexamethasone kg did not affect levels (2.7 0.75 0.34 h) or activity SD, −0.26 0.11).
Apoptosis of dentate granular cells in the hippocampal formation during bacterial meningitis may be mediated by glutamate toxicity. For this reason, we studied relationship between glutamine synthetase activity and regional neuronal apoptosis rabbits with experimental pneumococcal meningitis. The duration was 24 h, treatment started 16 h after infection. Significant increases protein concentration (P < 0.05) were found frontal cortex (n = 7) receiving ceftriaxone 12) as compared to control...
Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Introduction: There is suspicion that sharp cut hair fragments cause intergluteal pilonidal sinus disease. Barbers, exposed daily, have not been systematically investigated for risk. Methods: One hundred barbers in Northern Germany were interviewed regarding site and incidence of penetration as well methods/frequency self-epilation, using a structured questionnaire. Results: Ninety-two percent experience foreign penetration, mostly when cutting short dry hair. Despite daily showering...
F nuclei serve as versatile sensors for detecting protein interactions and dynamics in biomolecular NMR spectroscopy. Although various methods have been developed to incorporate fluorine-containing aromatic residues into proteins using