A5056651400- Laser-Matter Interactions and Applications
- Advanced Fiber Laser Technologies
- Spectroscopy and Quantum Chemical Studies
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Advanced Chemical Physics Studies
- Ion-surface interactions and analysis
- High-pressure geophysics and materials
- X-ray Spectroscopy and Fluorescence Analysis
- Topological Materials and Phenomena
- Cancer, Hypoxia, and Metabolism
- Advanced Semiconductor Detectors and Materials
- Strong Light-Matter Interactions
- Electron and X-Ray Spectroscopy Techniques
- Orbital Angular Momentum in Optics
- Laser-Plasma Interactions and Diagnostics
- Advanced Radiotherapy Techniques
- Mechanical and Optical Resonators
- Cancer, Lipids, and Metabolism
- Photonic and Optical Devices
- RNA modifications and cancer
- Organic and Molecular Conductors Research
- Plasmonic and Surface Plasmon Research
- Copper-based nanomaterials and applications
- Terahertz technology and applications
Wuhan University
2022-2025
Liaoning Cancer Hospital & Institute
2024
China Medical University
2014-2024
Beijing Institute of Technology
2022-2024
California Institute of Technology
2020-2023
Korea University
2022-2023
Purdue University West Lafayette
2023
SLAC National Accelerator Laboratory
2016-2021
Stanford University
2006-2021
Shenzhen University
2021
A novel nanoreservoir made of carbon nanotubes (CNTs) is proposed for realizing tougher and automated self-healing materials. The advantages the approach are that CNTs have potential to play role reinforcing elements prior after sealing a crack number voids reduced material themselves healed. focus this paper on investigating feasibility using as by analyzing dynamics fluid flowing out ruptured single-walled CNT (SWNT), where resembles an organic healing agent. With in mind escaping...
We experimentally demonstrate backward emission of high-harmonics a near-infrared laser from MgO and Si crystals in the direction specular reflection. show that variation high-harmonic power with angle incidence can be predicted nonlinear reflection coefficients derived originally for perturbative nonlinearities. A comparison transmission geometries suggests backward-propagating are an excellent reference to study propagation intense light solids. Backward will enable phase matching beam...
Entangled photons exhibit non-classical light–matter interactions that create new opportunities in materials and molecular science.
We present ultrafast optical pump-probe and x-ray diffraction measurements of the charge density wave dynamics in ${\mathrm{SmTe}}_{3}$ at 300 K. performed Linac Coherent Light Source to directly probe finite-wave-vector order parameter. The reveal coherent oscillations $\ensuremath{\sim}1.6$ THz that become overdamped with increasing fluence. identify this oscillation lattice component amplitude mode. Furthermore, our data allow for a clear identification mode frequency data. In both...
Plant-derived nanovesicles (PDNVs) derived from natural green products have emerged as an attractive nanoplatform in biomedical application. They are usually characterized by unique structural and biological functions, such the bioactive lipids/proteins/nucleic acids therapeutics targeting groups, immune-modulation, long-term circulation. With rapid development of nanotechnology, materials, synthetic chemistry, PDNVs can be engineered with multiple functions for efficient drug delivery...
We study ultrafast x-ray diffraction on the charge density wave (CDW) of ${\mathrm{SmTe}}_{3}$ using an free-electron laser. The high momentum and time resolution afforded by laser enabled capturing fine wave-vector time-dependent features CDW that originate from fast (in time) sharp real space) variations lattice distortion, which we attribute to inversion order parameter. These domain inversions occur near surface are caused short penetration depth near-infrared pump with wavelength...
Abstract Lipid metabolic reprogramming of tumor cells has been proven to play a critical role in initiation and development. However, lipid metabolism cancer‐associated fibroblasts (CAFs) rarely studied, particularly CAFs oral squamous cell carcinoma (OSCC). Additionally, the molecular mechanism by which regulate is unclear. In this study, we found that phosphorylated ATP citrate lyase (p‐ACLY), key enzyme, was upregulated OSCC CAFs. Compared paracancerous normal fibroblasts, showed enhanced...
We report channel-resolved measurements of the anharmonic coupling coherent ${A}_{1g}$ phonon in photoexcited bismuth to pairs high wave vector acoustic phonons. The decay a can be understood as parametric resonance process whereby atomic displacement periodically modulates frequency broad continuum modes. This drives temporal oscillations mean-square displacements at that are observed across Brillouin zone by femtosecond x-ray diffuse scattering. extract constants between and several...
Transient X-ray and extreme ultraviolet (XUV) spectroscopies have become invaluable tools for studying photoexcited dynamics due to their sensitivity carrier occupations local chemical or structural changes. One of the most studied materials using transient XUV spectroscopy is α-Fe2O3 because its rich dynamics, including small polaron formation. The interpretation effects in currently carried out a semi-empirical method that not transferrable materials. Here, an ab initio, Bethe-Salpeter...
Given the key roles of cancer associated fibroblasts (CAFs) in shaping tumor stroma, this study shows a CAF-associated ITGB1-inactivating peptide-enriched membrane nanodelivery system (designated as PMNPs-D) to simultaneously target CAFs and cells for boosted chemotherapy through promoted drug perfusion. In structure PMNPs-D, PLGA-based inner core is loaded with chemotherapeutic doxorubicin, outer surface cloaked by hybrid biomembranes insertion integrin β1 (ITGB1) inhibiting peptide (i.e.,...
Quantifying electron-phonon interactions for the surface states of topological materials can provide key insights into surface-state transport, superconductivity, and potentially how to manipulate state using a structural degree freedom. We perform time-resolved x-ray diffraction (XRD) angle-resolved photoemission (ARPES) measurements on Bi2Te3 Bi2Se3, following excitation coherent A1g optical phonons. extract compare deformation potentials coupling electronic local A1g-like displacements in...
Abstract Since the new millennium coherent extreme ultra-violet and soft x-ray radiation has revolutionized understanding of dynamical physical, chemical biological systems at electron’s natural timescale. Unfortunately, laser-based upconversion infrared photons to vacuum-ultraviolet high-order harmonics in gaseous, liquid solid targets is notoriously inefficient. In dense nonlinear media, limiting factor strong re-absorption generated high-energy photons. Here we overcome this limitation by...
Impulsive optical excitation can generate both coherent and squeezed phonons. The expectation value of the phonon displacement $<u_q>$ oscillates at mode frequency for state but remains zero a pure state. In contrast, show oscillations in $<|u_q|^2>$ twice frequency. Therefore it be difficult to distinguish them second-order measurement displacements, such as first-order x-ray diffuse scattering. Here we demonstrate simple method from atomic motion by scattering following double impulsive...
Elevated production of extracellular matrix (ECM) in tumor stroma is a critical obstacle for drug penetration. Here we demonstrate that ATP-citrate lyase (ACLY) significantly upregulated cancer-associated fibroblasts (CAFs) to produce ECM. Using self-assembling nanoparticle-design approach, carrier-free nanoagent (CFNA) fabricated by simply assembling NDI-091143, specific ACLY inhibitor, and doxorubicin (DOX) or paclitaxel (PTX), the first-line chemotherapeutic drug, via multiple noncovalent...
Abstract Background Cancer-associated fibroblasts (CAFs), a predominant stromal cell type in the tumor microenvironment, significantly affect progression of oral squamous carcinoma (OSCC). Results The specific mechanisms through which CAFs influence cancer stem phenotype OSCC are not fully understood. This study explored effects lactic acid produced by on cells (CSCs) cells. Our results demonstrated that exhibit increased glycolysis and production. Lactic treatment enhances CSCs-related...