A5063199948- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Reproductive System and Pregnancy
- Pregnancy and Medication Impact
- Peripheral Neuropathies and Disorders
- Advanced Neuroimaging Techniques and Applications
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Amyotrophic Lateral Sclerosis Research
- Systemic Lupus Erythematosus Research
- Functional Brain Connectivity Studies
- Vestibular and auditory disorders
- Long-Term Effects of COVID-19
- Cerebral Palsy and Movement Disorders
- Autoimmune and Inflammatory Disorders Research
- Acute Lymphoblastic Leukemia research
- Health Systems, Economic Evaluations, Quality of Life
- Pericarditis and Cardiac Tamponade
- Listeria monocytogenes in Food Safety
- Alzheimer's disease research and treatments
- Family Support in Illness
- Ectopic Pregnancy Diagnosis and Management
- Immunotherapy and Immune Responses
- Balance, Gait, and Falls Prevention
- Monoclonal and Polyclonal Antibodies Research
Associazione Italiana Sclerosi Multipla
2025
Sapienza University of Rome
2014-2024
Ospedale San Filippo Neri
2018-2024
ASL Roma
2018-2022
Istituto Neurologico Mediterraneo
2015-2019
Nini Hospital
2008-2019
Azienda Ospedaliera Sant'Andrea
2016-2019
Multiple Sclerosis Foundation
2018
Don Carlo Gnocchi Foundation
2018
Azienda Sanitaria Locale Roma 3
2018
To assess pregnancy and fetal outcomes after in utero exposure to interferon-β (IFNβ) all pregnancies occurring women with multiple sclerosis (MS) during the study period, a specific focus on risk of spontaneous abortion.In this cohort study, data were gathered through standardized, semi-structured interview. Patients who discontinued IFNβ less than 4 weeks from conception (exposed) compared those had drug at least or never treated (not exposed). Possible confounders handled multivariate...
<h3>Objective:</h3> To assess the relationship between breastfeeding and risk of puerperal relapses in a large cohort patients with multiple sclerosis (MS). <h3>Methods:</h3> We prospectively followed-up pregnancies occurring 2002 2008 women MS, recruited from 21 Italian MS centers, gathered data on through standardized interview. The after delivery was assessed using Cox regression analysis. <h3>Results:</h3> A total 302 out 423 298 resulted full-term deliveries. Patients were followed up...
To assess fetal risk after pregnancy exposure to natalizumab in women with multiple sclerosis (MS), a specific focus on spontaneous abortion (SA) and congenital anomalies (CA).Data of all pregnancies occurring between 2009 2015 patients MS treated referring 19 participating sites were collected compared those untreated injectable immunomodulatory agents. Rates SA CA also reported the Italian population. Multivariable logistic linear regression models performed.A total 92 tracked 83 women. In...
Abstract Background Few studies have systematically addressed the role of epidural analgesia and caesarean delivery in predicting post-partum disease activity women with Multiple Sclerosis (MS). The objective this study was to assess impact (EA) (CD) on risk relapses disability MS. Methods In context an Italian prospective safety immunomodulators pregnancy, we included pregnancies occurred between 2002 2008 MS regularly followed-up 21 centers. Data were gathered through a standardized,...
To evaluate whether an escalation approach was more effective in suppressing clinical and magnetic resonance imaging (MRI) activity than switching among immunomodulators relapsing-remitting multiple sclerosis (RRMS) patients.In this post-marketing, prospective, observational study two Italian (MS) centres, a total of 285 RRMS patients who failed first-line treatment with interferon beta (IFNβ) or glatiramer acetate (GA) were considered. Patients subdivided according to the strategy adopted...
Abstract Background Only few studies have assessed safety of in utero exposure to glatiramer acetate (GA). Following a previous study assessing the interferon beta (IFNB) pregnancy multiple sclerosis (MS), we aimed assess and fetal outcomes after GA, using same dataset, with specific focus on risk spontaneous abortion. Materials methods We recruited MS patients, prospectively followed-up 21 Italian Centres, for whom was recorded period 2002–2008. Patients were divided into 2 groups:...
<h3>Objective</h3> To assess relapses, disability progression and the role of disease modifying drugs (DMDs) in year after delivery women with multiple sclerosis (MS). <h3>Methods</h3> We prospectively followed-up pregnancies occurring between 2002 2008 MS, recruited from 21 Italian MS centres. The risk relapses was assessed using time-dependent Cox regression analysis. <h3>Results</h3> 350 out 423 were (pregnancies not resulting live birth a postpartum follow-up period shorter than 1...
Objective. To evaluate the effectiveness of a home-based cognitive rehabilitation (CR) program based on video game Dr Kawashima’s Brain Training (DKBT; Nintendo, Japan), in improving attention, processing speed, and working memory patients with multiple sclerosis (MS). Methods. This was randomized, wait-list control study. Patients MS failure at least one between Stroop Test (ST), Paced Auditory Serial Addition (PASAT), Symbol Digit Modalities (SDMT) were submitted to an 8-week CR playing...
To test the effect of oral contraceptives (OCs) in combination with interferon β (IFN-β) on disease activity patients relapsing-remitting multiple sclerosis (RRMS).One hundred fifty women RRMS were randomized a 1:1:1 ratio to receive IFN-β-1a subcutaneously (SC) only (group 1), SC plus ethinylstradiol 20 μg and desogestrel 150 2), or ethinylestradiol 40 125 3). The primary endpoint was cumulative number combined unique active (CUA) lesions brain MRI at week 96. Secondary endpoints included...
<h3>Objective</h3> To assess the risk of disease reactivation during pregnancy after natalizumab suspension in women with multiple sclerosis (MS). <h3>Methods</h3> Data all pregnancies occurring between 2009 and 2015 patients MS treated referring to 19 participating sites were collected compared those untreated injectable immunomodulatory agents through a 2-factor repeated measures analysis. Predictors activity assessed stepwise multivariable logistic regression models. <h3>Results</h3> A...
Purpose To investigate thalamic connectivity changes after use of a video game–based cognitive rehabilitation program, as damage and alterations in thalamocortical functional (FC) are important factors dysfunction patients with multiple sclerosis (MS). Materials Methods This prospective study was approved by the local ethical committee. Twenty-four MS impairment were randomly assigned to either an intervention or wait-list group. Patients evaluated tests 3-T resting-state magnetic resonance...
Objective This study aimed to define the minimal evidence of disease activity (MEDA) during treatment that can be tolerated without exposing patients with relapsing-remitting multiple sclerosis at risk long-term disability. Methods We retrospectively collected data followed up 10 years after starting interferon beta or glatiramer acetate. Survival analyses explored association between reaching an Expanded Disability Status Scale≥6.0 and early clinical MRI assessed first second year...
Abstract Spinal cord MRI is not routinely performed for multiple sclerosis (MS) monitoring. Here, we explored whether spinal activity offers any added value over brain clinical outcomes prediction in MS. This a retrospective, monocentric study including 830 MS patients who underwent longitudinal and [median follow-up 7 years (range: < 1–26)]. According to the presence (or absence) of defined as at least one new T2 lesion and/or gadolinium (Gd) enhancing lesion, each scan was classified...
Objective: The objective of this paper is to investigate four-year outcomes interferon beta (IFNB)-treated patients with multiple sclerosis (MS) according their clinical or magnetic resonance imaging (MRI) activity status at first year treatment. Methods: A total 370 MS duration ≤5 years before IFNB start were followed-up for four years. optimal threshold one-year MRI that more accurately predicted subsequent relapses disability worsening was identified. risk and after the then estimated by...
Background The humanized monoclonal alpha4-integrin antibody Natalizumab (NTZ) (Tysabri©, Biogen Idec, Cambridge, MA, USA) has shown to be effective in multiple sclerosis (MS) therapy; however, the interruption of drug been related a disease restart. This risk carefully considered case accidental or desired pregnancies. Aim study To report restart patients who interrupted NTZ because pregnancy and discuss implication choice female childbearing with MS. Methods Clinical histories MRI images...
<h3>Objective</h3> To directly compare fingolimod (FNG) and dimethyl fumarate (DMF) on no evident disease activity (NEDA) status in patients with relapsing-remitting multiple sclerosis (RRMS) from 7 outpatient clinics Central Italy. <h3>Methods</h3> We analyzed data of RRMS who started an oral agent, namely DMF or FNG, either as first treatment (naives) after switching self-injectable drugs (switchers). performed a propensity score (PS)–based nearest-neighbor matching within caliper 0.05 to...
To evaluate the accuracy of a data-driven approach, such as machine learning classification, in predicting disability progression MS.We analyzed structural brain images 163 subjects diagnosed with MS acquired at two different sites. Participants were followed up for 2-6 years, defined according to expanded status scale (EDSS) increment follow-up. T2-weighted lesion load (T2LL), thalamic and cerebellar gray matter (GM) volumes, fractional anisotropy normal appearing white calculated baseline...
The aim of this study was to test the contribution anti-myelin antibodies in predicting conversion from clinically isolated syndrome (CIS) multiple sclerosis (MS) when considering either Poser's or McDonald's diagnostic criteria. Fifty-one patients with CIS and abnormal brain MRI were imaged monthly for six months then at 12, 18, 24, 36 months. At baseline serum samples testing against myelin oligodendrocyte glycoprotein (anti-MOG) basic protein (anti-MBP) collected. During 36-month...
Background.— Some multiple sclerosis (MS)‐specific therapies may exacerbate a comorbid migraine. Whereas data regarding the impact of interferon beta (IFNB) on this comorbidity have been reported, studies role natalizumab (NTZ) are still lacking. Purpose.— Our aim was to compare IFNB and NTZ frequency disability migraine in MS patients. Methods.— We performed longitudinal evaluation patients with previously assessed at our center retested for present study, by comparing from 33 originally...
Background and objective: The dentate nucleus, which is the largest of cerebellar nuclei, plays a critical role in movement cognition. aim our study was to assess any changes functional connectivity (FC) adult relapsing remitting multiple sclerosis (RR-MS) patients investigate possible clinical correlates. Materials methods: In all, 54 24 healthy subjects (HS) underwent multimodal magnetic resonance imaging (MRI), including diffusion tensor (DTI), three-dimensional-T1-weighted resting state...