A5036649557- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Vestibular and auditory disorders
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Peripheral Neuropathies and Disorders
- Cerebral Palsy and Movement Disorders
- Migraine and Headache Studies
- Fetal and Pediatric Neurological Disorders
- Viral Infections and Immunology Research
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Powdery Mildew Fungal Diseases
- Sphingolipid Metabolism and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Ultrasound and Hyperthermia Applications
- Obsessive-Compulsive Spectrum Disorders
- EEG and Brain-Computer Interfaces
- Neurological Disease Mechanisms and Treatments
- HIV Research and Treatment
- Systemic Lupus Erythematosus Research
Istituto Neurologico Mediterraneo
2016-2024
Sapienza University of Rome
2013-2024
Fondazione Santa Lucia
2013-2017
Istituti di Ricovero e Cura a Carattere Scientifico
2014
Diffusion tensor imaging (DTI) is an effective means of quantifying parameters demyelination and axonal loss. The application DTI in Multiple Sclerosis (MS) has yielded noteworthy results. abnormalities, which are already detectable patients with clinically isolated syndrome (CIS), become more pronounced as disease duration neurological impairment increase. assessment the microstructural alterations white grey matter MS may shed light on mechanisms responsible for irreversible disability...
To investigate, by using resting-state (RS) functional magnetic resonance (MR) imaging, thalamocortical connectivity (FC) and its correlations with cognitive impairment in multiple sclerosis (MS).All subjects provided written informed consent; the study protocol was approved university institutional review board for this HIPAA-compliant study. Forty-eight patients relapsing-remitting MS 24 control underwent multimodal MR including diffusion-tensor three-dimensional (3D) T1-weighted imaging...
Multiple sclerosis (MS) is characterized by demyelinating and degenerative processes within the central nervous system. Unlike conventional MRI,new advanced imaging techniques improve pathological specificity better highlight relationship between anatomical damage clinical impairment.To investigate disability both grey (GM) white matter (WM) regional in MS patients.Thirty-six relapsing remitting-MS patients 25 sex- age-matched controls were enrolled. All clinically evaluated Expanded...
Purpose To determine if high-intensity, task-oriented, visual feedback training with a video game balance board (Nintendo Wii) induces significant changes in diffusion-tensor imaging ( DTI ) parameters of cerebellar connections and other supratentorial associative bundles these are related to clinical improvement patients multiple sclerosis. Materials Methods The protocol was approved by local ethical committee; each participant provided written informed consent. In this 24-week, randomized,...
To define the predictive value of clinical and magnetic resonance imaging (MRI) characteristics in identifying relapsing-remitting multiple sclerosis (RR-MS) patients with sustained disability progression during interferon beta (IFNB) treatment.All receiving treatment one available IFNB formulations for at least 1 year were included this single-centre, prospective post-marketing study. Demographic, MRI data collected start therapy; followed-up yearly. Poor response was defined as occurrence...
Purpose To combine two unbiased (ie, without any a priori hypothesis) magnetic resonance (MR) imaging processing approaches, tract-based spatial statistics and voxel-based morphometry, to investigate the relationship between white matter gray damage computer-based measures of balance impairment assessed at static posturography in patients with multiple sclerosis (MS). Materials Methods Institutional review board approval written informed consent were obtained. Forty-five ambulatory MS (34...
Purpose To investigate thalamic connectivity changes after use of a video game–based cognitive rehabilitation program, as damage and alterations in thalamocortical functional (FC) are important factors dysfunction patients with multiple sclerosis (MS). Materials Methods This prospective study was approved by the local ethical committee. Twenty-four MS impairment were randomly assigned to either an intervention or wait-list group. Patients evaluated tests 3-T resting-state magnetic resonance...
Neuroimaging studies suggest that changes in the cerebellar-basal ganglia-thalamo-cortical sensorimotor circuit are a pathophysiologic feature of focal dystonia. However, it remains unclear whether structural and functional alterations vary different forms Thus, patients with cervical dystonia (CD) blepharospasm (BSP), we aimed to investigate damage resting-state using whole-brain seed-based approaches test hypothesis possible connectivity (FC) specific circuits, including cerebellum, basal...
Background and objective: To define the pathological substrate underlying disability in multiple sclerosis by evaluating relationship of resting-state functional connectivity with microstructural brain damage, as assessed diffusion tensor imaging, clinical impairments. Methods: Thirty relapsing–remitting patients 24 controls underwent 3T-MRI; motor abilities were evaluated using measures walking speed, hand dexterity balance capability, while information processing speed was a paced auditory...
Pathological and MRI-based evidence suggests that multiple brain structures are likely to be involved in functional disconnection between areas. Few studies have investigated resting-state connectivity (rsFC) progressive supranuclear palsy (PSP) corticobasal syndrome (CBS). In this study, we within- between-network rsFC abnormalities these two conditions.Twenty patients with PSP, 11 CBS, 16 healthy subjects (HS) underwent a fMRI study. Resting-state networks (RSNs) were extracted evaluate...
To evaluate the accuracy of a data-driven approach, such as machine learning classification, in predicting disability progression MS.We analyzed structural brain images 163 subjects diagnosed with MS acquired at two different sites. Participants were followed up for 2-6 years, defined according to expanded status scale (EDSS) increment follow-up. T2-weighted lesion load (T2LL), thalamic and cerebellar gray matter (GM) volumes, fractional anisotropy normal appearing white calculated baseline...
Biomarker-based differential diagnosis of the most common forms dementia is becoming increasingly important. Machine learning (ML) may be able to address this challenge. The aim study was develop and interpret a ML algorithm capable differentiating Alzheimer's dementia, frontotemporal with Lewy bodies cognitively normal control subjects based on sociodemographic, clinical, magnetic resonance imaging (MRI) variables. 506 from 5 databases were included. MRI images processed FreeSurfer, LPA,...
Substantial evidence highlights the role of cerebellum in pathophysiology tremor essential (ET), although its potential involvement altered movement execution this condition remains unclear. This study aims to explore correlations between and basal ganglia functional connectivity voluntary abnormalities ET, objectively assessed with kinematic techniques. A total 20 patients diagnosed ET 18 healthy subjects were enrolled study. Tremor repetitive finger tapping recorded using an optoelectronic...
Background Telerehabilitation (TR) offers a valuable opportunity to improve access care and has shown results comparable onsite rehabilitation (SR) across different conditions. The present study aimed explore the efficacy of TR SR in improving clinically meaningful outcomes people with multiple sclerosis (pwMS). Materials methods Subjects enrolled were assigned one two treatment arms: 6-week intervention or intervention. Pre-and post-intervention evaluation included assessment global...
Objective: To evaluate whether balance deficit in patients with multiple sclerosis (MS), as assessed eyes opened (EO) and closed (EC), is associated damage of different structures the central nervous system (CNS). Methods: Fifty MS 20 healthy controls (HCs) underwent static posturography to calculate body’s center pressure displacement (COP path) EO EC. They were scanned using a 3.0T magnet obtain PD/T2 3D-T1-weighted images brain spinal cord. We determined mid-sagittal cerebellum area...
Background and objective: The dentate nucleus, which is the largest of cerebellar nuclei, plays a critical role in movement cognition. aim our study was to assess any changes functional connectivity (FC) adult relapsing remitting multiple sclerosis (RR-MS) patients investigate possible clinical correlates. Materials methods: In all, 54 24 healthy subjects (HS) underwent multimodal magnetic resonance imaging (MRI), including diffusion tensor (DTI), three-dimensional-T1-weighted resting state...
<h3>BACKGROUND AND PURPOSE:</h3> Studies on functional connectivity in progressive supranuclear palsy have been restricted to the thalamus and midbrain tegmentum. The present study aims evaluate abnormalities of subcortical structures these patients. Functional will be correlated with motor nonmotor symptoms disease. <h3>MATERIALS METHODS:</h3> Nineteen patients (mean age, 70.93 ± 5.19 years) 12 age-matched healthy subjects 69.17 5.20 underwent multimodal MR imaging, including fMRI at rest,...
Brain plasticity is the basis for systems-level functional reorganization that promotes recovery in multiple sclerosis (MS). As inflammation interferes with plasticity, its pharmacological modulation may restore by promoting desired patterns of reorganization. Here, we tested hypothesis brain probed a visuomotor adaptation task impaired MS and reduction facilitates restoration. patients were assessed twice before (sessions 1 2) once after (session 3) beginning Interferon beta (IFN beta),...
Purpose To prospectively investigate, by using resting-state functional magnetic resonance (MR) imaging, cerebellar dentate nuclei (DNs) connectivity abnormalities in multiple sclerosis (MS) to explore their impact on balance impairment patients with MS, considering the role of DNs and projections maintaining balance, posture, muscle tone, Materials Methods All subjects provided written informed consent, protocol was approved university institutional review board. Twenty-five...