A5026807077- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Parental Involvement in Education
- Functional Brain Connectivity Studies
- Education Systems and Policy
- Higher Education Research Studies
- Atomic and Subatomic Physics Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Vestibular and auditory disorders
- Community Development and Social Impact
- Peripheral Neuropathies and Disorders
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Higher Education Learning Practices
- MRI in cancer diagnosis
- Higher Education and Employability
- Death Anxiety and Social Exclusion
- Diabetes Management and Education
- Empathy and Medical Education
- Aesthetic Perception and Analysis
- Neurological disorders and treatments
- Accounting Education and Careers
- Inclusion and Disability in Education and Sport
- Healthcare innovation and challenges
Public Health Scotland
2024
Cardiff University
2016-2022
Wales Institute of Social and Economic Research, Data and Methods
2021-2022
Concordia University
2018-2019
University of Stirling
2011-2012
Brandon University
2007
University of Wisconsin–La Crosse
2001
St. Mary Medical Center
2001
This research tested the role of traditional rational-cognitive factors and emotional barriers to posthumous organ donation. An example an barrier is "ick" factor, a basic disgust reaction idea We also potential manipulating anticipated regret increase intention donate in people who are not yet registered donors.In three experiments involving 621 members United Kingdom general public, participants were invited complete questionnaire measures tapping affective attitude such as desire retain...
Long-term exercise interventions have been shown to be a potent trigger for both neurogenesis and vascular plasticity. However, little is known about the underlying temporal dynamics specifically when exercise-induced adaptations first occur, which vital therapeutic applications. In this study, we investigated whether single session of moderate-intensity was sufficient induce changes in cerebral vasculature. We employed arterial spin labeling magnetic resonance imaging measure global...
Abstract Quantifying white matter damage in vivo is becoming increasingly important for investigating the effects of neuroprotective and repair strategies multiple sclerosis (MS). While various approaches are available, relationship between MRI‐based metrics microstructure disease, that is, to what extent provide complementary versus redundant information, remains largely unexplored. We obtained four microstructural from 123 MS patients: fractional anisotropy (FA), radial diffusivity (RD),...
Objective: To systematically review international evidence on the effectiveness and cost-effectiveness of interventions targeting mental health, wellbeing, retention child family social workers their impact outcomes.Method:Systematic narrative synthesis quantitative comparative studies. Published or unpublished research was sought via 12 bibliographic databases, websites, contact with experts, citation tracking. Studies in any language were eligible for inclusion. Quality assessed using...
Dual-calibrated fMRI is a multi-parametric technique that allows for the quantification of resting oxygen extraction fraction (OEF), absolute rate cerebral metabolic consumption (CMRO
Aging is accompanied by vascular and structural changes in the brain, which include decreased grey matter volume (GMV), cerebral blood flow (CBF), cerebrovascular reactivity (CVR). Enhanced fitness aging has been related to preservation of GMV CBF, some cases CVR, although there are contradictory relationships reported between CVR fitness. To gain a better understanding complex interplay GMV, CBF present study assessed these factors concurrently. Data from 50 participants, aged 55 72, were...
Brain plasticity is the basis for systems-level functional reorganization that promotes recovery in multiple sclerosis (MS). As inflammation interferes with plasticity, its pharmacological modulation may restore by promoting desired patterns of reorganization. Here, we tested hypothesis brain probed a visuomotor adaptation task impaired MS and reduction facilitates restoration. patients were assessed twice before (sessions 1 2) once after (session 3) beginning Interferon beta (IFN beta),...
Cerebral energy deficiency is increasingly recognised as an important feature of multiple sclerosis (MS). Until now, we have lacked non-invasive imaging methods to quantify utilisation and mitochondrial function in the human brain. Here, used novel dual-calibrated functional magnetic resonance (dc-fMRI) map grey-matter (GM) deoxy-haemoglobin sensitive cerebral blood volume (CBV dHb ), flow (CBF), oxygen extraction fraction (OEF), metabolic rate consumption (CMRO 2 ) patients with MS (PwMS)...
Abstract Exercise is beneficial for brain health, inducing neuroplasticity and vascular plasticity in the hippocampus, which possibly mediated by brain-derived neurotrophic factor (BDNF) levels. Here we investigated short-term effects of exercise, to determine if a 1-week intervention sufficient induce changes. Fifteen healthy young males completed five supervised exercise training sessions over seven days. This was preceded followed multi-modal magnetic resonance imaging (MRI) scan...
This cross-sectional study investigated the effects of aerobic fitness on cerebrovascular function in healthy brain. Gray matter cerebral blood flow (CBF) and reactivity (CVR) were quantified a sample young adults within normal range. Based existing Transcranial Doppler ultrasound fMRI evidence, we predicted positive relationship between resting gray CBF CVR. Exploratory hypotheses that higher V. O2peak would be associated with GM volume cognitive performance also investigated. 20 underwent...
The development of tailored recovery-oriented strategies in multiple sclerosis requires early identification an individual's potential for functional recovery.To identify predictors visuomotor performance improvements, a proxy recovery, using predictive statistical model that combines demographic, clinical and magnetic resonance imaging (MRI) data.Right-handed patients underwent baseline disability assessment MRI the brain structure, function vascular health. They subsequently undertook 4...
Abstract The cross-sectional study investigated the effects of aerobic fitness on cerebrovascular function in healthy brain. We quantified grey matter (GM) cerebral blood flow (CBF) and reactivity (CVR), a sample young adults within normal range. Based existing TCD fMRI evidence, we predicted positive relationship between resting GM CBF, CVR. Exploratory hypotheses that higher peak would be associated with volume cognitive performance were also investigated. 20 underwent test battery tests....
The brain retains a lifelong ability to adapt through learning and in response injury or disease-related damage, process known as functional neuroplasticity. neural energetics underlying plasticity have not been thoroughly investigated experimentally the healthy human brain. A better understanding of blood flow metabolic changes that accompany motor skill acquisition, which facilitate plasticity, is needed before subsequent translation treatment interventions for recovery function disease....
One promising approach for mapping CMRO2 is dual-calibrated functional MRI (dc-fMRI). This method exploits the Fick Principle to combine estimates of CBF from ASL, and OEF derived BOLD-ASL measurements during arterial O2 CO2 modulations. Multiple gas modulations are required decouple deoxyhemoglobin-sensitive blood volume. We propose an alternative single calibrated fMRI framework, integrating a model oxygen transport, that links volume creates between maximum BOLD signal, (and CMRO2)....
We report three experiments intended to characterise aspects of the 'double face' illusion, formed by replicating eyes and mouth below originals. Such doubled faces are disturbing look at. find there wide individual differences in ability detect that a face has been when presented briefly masked. These appear relate perceptual speed, since they correlate with identify famous face. Doubling significant effect on identification, though much less than inversion. In reaction-time study,...
Abstract The neural energetics underlying functional brain plasticity have not been thoroughly investigated in the healthy human brain. A better understanding of blood flow and metabolism changes will help us to address pathologies which is compromised and, with interventions, could be enhanced for patient benefit. Calibrated fMRI was conducted 20 participants during performance a serial reaction time task induces rapid motor adaptation. Regions interest (ROIs) were defined from areas...