A5057624781- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Multiple Sclerosis Research Studies
- Atomic and Subatomic Physics Research
- Acute Ischemic Stroke Management
- Neonatal and fetal brain pathology
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Visual perception and processing mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Spinal Cord Injury Research
- Neurobiology of Language and Bilingualism
- Spatial Neglect and Hemispheric Dysfunction
- Cardiovascular Syncope and Autonomic Disorders
- Optical Imaging and Spectroscopy Techniques
- Neurological Disease Mechanisms and Treatments
- Nonmelanoma Skin Cancer Studies
- Ultrasound Imaging and Elastography
- Cancer and Skin Lesions
- Heart Rate Variability and Autonomic Control
- Ultrasound and Hyperthermia Applications
- Transcranial Magnetic Stimulation Studies
Enrico Fermi Center for Study and Research
2015-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2025
Fondazione Santa Lucia
2019-2025
University of Chieti-Pescara
2021-2023
Ospedale SS. Annunziata
2022
University of Salerno
2019
University of Turin
2016
Sapienza University of Rome
2015
Phasic changes in eye's pupil diameter have been repeatedly observed during cognitive, emotional and behavioral activity mammals. Although is known to be associated with noradrenergic firing the pontine Locus Coeruleus (LC), thus far causal chain coupling spontaneous dynamics specific cortical brain networks remains unknown. In present study, we acquired steady-state blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) data combined eye-tracking pupillometry...
Low frequency fluctuations (LFFs) of the BOLD signal are a major discovery in study resting brain with functional magnetic resonance imaging (fMRI). Two fMRI-based measures, connectivity (FC), measure synchronicity, and amplitude LFFs (ALFF), periodicity, have been proved to be sensitive changes induced by several neurological diseases, including degenerative dementia. In spite increasing use these whether how they related each other remains elucidated. this work we used voxel-wise FC ALFF...
Processing of incoming sensory stimulation triggers an increase cerebral perfusion and blood oxygenation (neurovascular response) as well alteration the metabolic neurochemical profile (neurometabolic response). Here, we show in human primary visual cortex (V1) that perceived unperceived isoluminant chromatic flickering stimuli designed to have similar neurovascular responses measured by level-dependent functional magnetic resonance imaging (BOLD-fMRI) markedly different neurometabolic...
Repetitive transcranial magnetic stimulation (rTMS) is a non‐invasive brain method commonly used in the disciplines of neuroscience, neurology and neuropsychiatry to examine or modulate function. Low frequency rTMS (e.g., 1 Hz) associated with net suppression cortical excitability, whereas higher frequencies 5 purportedly increase excitability. Magnetic resonance spectroscopy (MRS) resting-state functional MRI (rsfMRI) allow investigation neurochemistry connectivity, respectively, can assess...
Abstract In‐scanner head motion represents a major confounding factor in functional connectivity studies and it raises particular concerns when correlates with the effect of interest. One such instance regards research focused on modulations induced by sustained cognitively demanding tasks. Indeed, cognitive engagement is generally associated substantially lower in‐scanner movement compared unconstrained, or minimally constrained, conditions. Consequently, reliability condition‐dependent...
Functional magnetic resonance imaging time-series are conventionally processed by linear modelling the evoked response as convolution of experimental conditions with a stereotyped haemodynamic function (HRF). However, neural signal in to stimulus can vary according task, brain region, and subject-specific conditions. Moreover, HRF shape has been suggested carry physiological information. The BOLD across range sensorial cognitive tasks was fitted using sine series expansion, modelled signals...
Background Functional Magnetic Resonance Imaging (fMRI) is based on the Blood Oxygenation Level Dependent contrast and has been exploited for indirect study of neuronal activity within both brain spinal cord. However, interpretation cord fMRI (scfMRI) still controversial its adoption rather restricted because technical limitations. Overcoming these limitations would have a beneficial effect assessment follow-up injuries neurodegenerative diseases. Purpose This was aimed at systematically...
In preterm (PT) infants, regional cerebral blood flow (CBF) disturbances may predispose to abnormal brain maturation even without overt injury. Therefore, it would be informative determine the spatial distribution of grey matter (GM) CBF in PT and full-term (FT) newborns at term-equivalent age (TEA) assess relationship between features pattern both prematurity prematurity-related lesions. this prospective study, we obtained measures 66 (51 15 with lesions) 38 FT through pseudo-continuous...
Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a condition that often evolves into Parkinson's disease (PD). Therefore, by monitoring iRBD it possible to track the neurodegeneration of individuals who may progress PD. Here we aimed at piloting characterization brain tissue properties in mid-brain subcortical regions 10 healthy subjects, 8 iRBD, and 9 early-diagnosed We used battery magnetic resonance imaging (MRI) contrasts 3 T, including adiabatic non-adiabatic rotating...
Spontaneous low-frequency Blood-Oxygenation Level-Dependent (BOLD) signals acquired during resting state are characterized by spatial patterns of synchronous fluctuations, ultimately leading to the identification robust brain networks. The resting-state networks, including Default Mode Network (DMN), demonstrated persist sustained task execution, but exact features task-related changes network properties still not well characterized. In this work we sought examine in a group 20 healthy...
Brain activity at rest is characterized by widely distributed and spatially specific patterns of synchronized low-frequency blood-oxygenation level-dependent (BOLD) fluctuations, which correspond to physiologically relevant brain networks. This network behaviour known persist also during task execution, yet the details underlying task-associated modulations within- between-network connectivity are largely unknown. In this study we exploited a multi-parametric multi-scale approach investigate...
Functional Magnetic Resonance Imaging (fMRI) based on Blood Oxygenation Level Dependent (BOLD) contrast has become one of the most powerful tools in neuroscience research. On other hand, fMRI approaches have seen limited use study spinal cord and subcortical brain regions (such as brainstem portions diencephalon). Indeed obtaining good BOLD signal these areas still represents a technical scientific challenge, due to poor control physiological noise overall quality functional series. A...
Abstract Visuospatial attention is strongly lateralized, with the right hemisphere commonly exhibiting stronger activation and connectivity patterns than left during attentive processes. However, whether such asymmetry influences inter‐hemispheric information transfer behavioral performance not known. Here we used a region of interest (ROI) network‐based approach to determine steady‐state fMRI functional (FC) in whole cerebral cortex leftward/rightward covert visuospatial task. We found that...
Abstract Background and purpose Reduced cerebral perfusion has been observed in multiple sclerosis (MS) may contribute to tissue loss both acutely chronically. Here, we test the hypothesis that hypoperfusion occurs MS relates presence of irreversible damage. Methods In 91 patients with relapsing 26 healthy controls (HC), gray matter (GM) blood flow (CBF) was assessed using pulsed arterial spin labeling. GM volume, T1 hypointense T2 hyperintense lesion volumes (T1LV T2LV, respectively),...
Abstract Cerebrovascular reactivity (CVR) reflects the capacity of brain’s vasculature to increase blood flow following a vasodilatory stimulus. Reactivity is an essential property vessels that maintains nutrient supplies in face changing demand. In Multiple Sclerosis (MS), CVR may be diminished with brain inflammation and this contribute neurodegeneration. We test hypothesis altered MS neuroinflammation it restored when reduced. Using breath-hold task during functional Magnetic Resonance...
Spontaneous oscillations of the Blood Oxygenation Level-Dependent (BOLD) signal are spatially synchronized within specific brain networks and thought to reflect activity. Networks modulated by performance a task, even if exact features degree such modulations still elusive. The presence showing anticorrelated fluctuations lend initially suppose that competitive relationship between default mode network task positive supports efficiency processing. However, more recent results indicate...
One promising approach for mapping CMRO2 is dual-calibrated functional MRI (dc-fMRI). This method exploits the Fick Principle to combine estimates of CBF from ASL, and OEF derived BOLD-ASL measurements during arterial O2 CO2 modulations. Multiple gas modulations are required decouple deoxyhemoglobin-sensitive blood volume. We propose an alternative single calibrated fMRI framework, integrating a model oxygen transport, that links volume creates between maximum BOLD signal, (and CMRO2)....
Time-domain analysis of blood-oxygenation level-dependent (BOLD) signals allows the identification clusters voxels responding to photic stimulation in primary visual cortex (V1). However, characterization information encoding into temporal properties BOLD an activated cluster is poorly investigated. Here, we used Shannon entropy determine spatial and signal within most strongly area human during a hemifield stimulation. We determined distribution profile epochs at rest under small (19-121...
BACKGROUND: Functional Magnetic Resonance Imaging (fMRI) is based on the Blood Oxygenation Level Dependent contrast and has been exploited for indirect study of neuronal activity within both brain spinal cord. However, interpretation cord fMRI (scfMRI) still controversial its diffusion rather limited because technical limitations. Overcoming these limitations would have a beneficial effect assessment follow-up injuries neurodegenerative diseases. PURPOSE: This was aimed at systematically...
We characterized a deconvolved haemodynamic response function (dHRF) across the whole cortex exploiting sine series expansion in cohort of young healthy subjects from Human Connectome Project. report, for different tasks and brain regions, amplitude, latency, time-to-peak full-width at half maximum fitted BOLD dHRF. show that each those parameters vary throughout and, to smaller extent, subjects. Additionally, use flexible model, like one we explored this study, reveals HRF some regions...
We have studied Relapsing-Remitting Multiple Sclerosis (RRMS) patients group with spinal cord fMRI during a multilevel force grip motor task. demostrated the possibility to use as biomarker for clinical application.
In this study, we sought to determine by 3T MRI the cerebral blood flow (CBF) responses hypoglycemia (HG) in nondiabetic controls exposed either two euglycemic or hypoglycemic clamps on day before (EU- HYPO-preconditioning, respectively). Under belief that HYPO-preconditioning induces hypoglycemia-associated autonomic failure (HAAF) with blunting of counter-regulatory hormone and symptom HG (Arbelaez et al, 2008), hypothesized CBF after would resemble those reported T1D subjects impaired...