A5046061605- Advanced Semiconductor Detectors and Materials
- Semiconductor Quantum Structures and Devices
- CRISPR and Genetic Engineering
- Plant tissue culture and regeneration
- Plant Virus Research Studies
- Plant and Fungal Interactions Research
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cynara cardunculus studies
- Plant Disease Management Techniques
- Nuts composition and effects
- Sarcoidosis and Beryllium Toxicity Research
- Pain Mechanisms and Treatments
- Photorefractive and Nonlinear Optics
- Optical and Acousto-Optic Technologies
- Herpesvirus Infections and Treatments
- Insect-Plant Interactions and Control
- Acupuncture Treatment Research Studies
- Reading and Literacy Development
- Chalcogenide Semiconductor Thin Films
- T-cell and Retrovirus Studies
- HIV Research and Treatment
- Plant and fungal interactions
- Insect symbiosis and bacterial influences
University of Turin
2002-2024
University of Padua
1993-2024
Istituto Oncologico Veneto
2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
University of Milan
2003-2017
IRCCS Eugenio Medea
2009-2017
Istituto Ortopedico Galeazzi
2016
European Institute of Oncology
2007
Philogen (Italy)
2007
Bayer (Italy)
2007
Human epidermal growth factor receptor 2 (HER2) is a well-known oncogenic driver in different tumors and an approved therapeutic target breast gastroesophageal cancer. In metastatic colorectal cancer, only 3% to 5% of patients present with HER2 alterations: somatic mutations amplifications. was first assessed as biomarker resistance anti-EGFR therapy; however, more recent years, its role potential actionable has emerged. this article, we discuss the predictive prognostic value emerging...
Abstract Painful neuropathy is one of the complications diabetes mellitus that adversely affects patients’quality life. Pharmacological treatments are not fully satisfactory, and novel approaches needed. In a preclinical mouse model effect both human mesenchymal stromal cells from adipose tissue (hASC) their conditioned medium (hASC-CM) was evaluated. Diabetes induced by streptozotocin. After neuropathic hypersensitivity established, mice were intravenously injected with either 1 × 10 6 hASC...
Polyphenol oxidases (PPOs) catalyze the oxidization of polyphenols, which in turn causes browning eggplant berry flesh after cutting. This has a negative impact on fruit quality for both industrial transformation and fresh consumption. Ten PPO genes (named SmelPPO1 - 10 ) were identified thanks to recent availability high-quality genome sequence. A CRISPR/Cas9-based mutagenesis approach was applied knock-out three target ( SmelPPO4, SmelPPO5 , SmelPPO6) showed high transcript levels An...
Globe artichoke (Cynara cardunculus L. var. scolymus) is a rich source of compounds promoting human health (phytonutrients), among them caffeoylquinic acids (CQAs), mainly represented by chlorogenic acid (CGA), and dicaffeoylquinic (diCQAs). The enzymes involved in their biosynthesis belong to the large family BAHD acyltransferases. Following survey globe genome, we identified 69 proteins carrying catalytic site (HXXXD). Their phylogenetic analysis together with another 43 proteins, from 21...
Castanea sativa is an important tree nut species worldwide, highly appreciated for its multifunctional role, in particular timber and production. Nowadays, new strategies are needed to achieve plant resilience diseases, climate change, higher yields, nutritional quality. Among the breeding techniques (NPBTs), CRISPR/Cas9 system represents a powerful tool improve short time inexpensive way. In addition, construct can be delivered into cells form of ribonucleoproteins (RNPs), avoiding...
DNA methylation through the activity of cytosine-5-methyltransferases (C5-MTases) and demethylases plays important roles in genome protection as well regulating gene expression during plant development response to environmental stresses. In this study, we report on a genome-wide identification six C5-MTases (SmelMET1, SmelCMT2, SmelCMT3a, SmelCMT3b, SmelDRM2, SmelDRM3) five (SmelDemethylase_1, SmelDemethylase_2, SmelDemethylase_3, SmelDemethylase_4, SmelDemethylase_5) eggplant. Gene...
Phytophthora infestans, the causal agent of late blight (LB) in tomato (Solanum lycopersicum L.), is a devastating disease and serious concern for plant productivity. The presence susceptibility (S) genes plants facilitates pathogen proliferation; thus, disabling these may help provide broad-spectrum durable type tolerance/resistance. Previous studies on Arabidopsis have highlighted that knock-out mutants PMR4 gene are tolerant to powdery mildew. Moreover, knock-down potato has been shown...
Recently, a novel receptor superfamily has been identified whose members interact with parallel family of ligands showing homology to tumor necrosis factor (TNF). To investigate the role these structures in pulmonary environment, we evaluated expression some TNF-receptor (CD27, CD30, CD40, CD95/Fas, CD120a, and CD120b) TNF-ligand (CD40L, CD70/CD27L, CD30L, mTNFalpha) superfamilies by bronchoalveolar lavage (BAL) T cells recovered from healthy subjects patients interstitial lung disease...
The CRISPR/Cas9 ribonucleoprotein (RNP)-mediated technology represents a fascinating tool for modifying gene expression or mutagenesis as this system allows obtaining transgene-free plants, avoiding exogenous DNA integration. Holm oak ( Quercus ilex ) has an important social, economic, and ecological role in the Mediterranean climate zones of Western Europe North Africa is severely affected by decline syndrome. Here we report first example application CRISPR/Cas9-RNP holm oak. Firstly,...
Background/Objectives: Verbs are considered to be more abstract than nouns, as they represent actions, states, and events, which less tangible, flexible in their meaning thus univocally specified. It has been suggested that children acquire concepts based on linguistic contexts of use, making use semantic syntactic cues. By contrast, according theories embodied cognition, conceptual knowledge is physical perceptual interaction with the world. The present study investigates whether verbal...
The objective of the present research study was to understand what benefits use audiobooks (both school-books and books various genres, recorded on digital media) could bring preadolescents adolescents with developmental dyslexia. Two groups, each consisting 20 adolescents, were compared. experimental group used audiobooks, while control continued normal books. After 5 months training, showed a significant improvement in reading accuracy, reduced unease emotional-behavioural disorders, as...
High amounts of TNF-alpha are released by alveolar macrophages (AMs) in the lungs patients with HIV-1 infection. To investigate role this cytokine local immune response, we studied expression surface receptors for (TNF-Rs) and presence transmembrane form (mTNF-alpha) on bronchoalveolar lavage (BAL) cells recovered from 14 The both events leading to T cell alveolitis as a mediator cytotoxicity was also evaluated. TNF-R determined flow cytometry BAL CD8 lymphocytes AMs (i.e., that account...
We have studied the effects of ionizing and non-ionizing radiation on breakdown properties different types MOS capacitors, with thick (200 nm) thin (down to 8 oxides. In general, no large variations average field, time-to-breakdown at constant voltage, or charge-to-breakdown values been observed after high dose irradiation (20 Mrad(Si) 9 MeV electrons oxides, 17(Si) Mrad Co/sup 60/ gamma 10/sup 14/ neutrons/cm/sup 2/ only oxides). However, some modifications cumulative failure distributions...
3057 Background: L19-IL2 is a tumor targeting immunocytokine constituted by single chain Fragment variable format directed against ED-B domain of fibronectin and the human cytokine interleukin-2 (IL-2). It has striking anticancer activity in preclinical models. We evaluated safety, pharmacokinetic profile (PK) advanced cancer patients. Patients Methods: Five cohorts patients with recurrent/refractory solid tumors received dose escalation intravenous infusion (5, 10, 15, 22.5 e 30 Mio IU IL2...
It has been shown that abstract concepts are more difficult to process and acquired later than concrete concepts. We analysed the percentage of words in narrative lexicon individuals with Williams Syndrome (WS) as compared Down (DS) typically developing (TD) peers. The cognitive profile WS is characterized by visual-spatial difficulties, while DS presents predominant impairments linguistic abilities. predicted if abilities crucial development use an vocabulary, participants should display a...