A5039023886- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Medical Imaging and Pathology Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Cardiac Imaging and Diagnostics
- Cancer Genomics and Diagnostics
- Advanced MRI Techniques and Applications
- Fibroblast Growth Factor Research
- Radiomics and Machine Learning in Medical Imaging
- Proteoglycans and glycosaminoglycans research
- Ultrasound and Hyperthermia Applications
- Extracellular vesicles in disease
- Estrogen and related hormone effects
- Single-cell and spatial transcriptomics
- Histone Deacetylase Inhibitors Research
- Kruppel-like factors research
- Acupuncture Treatment Research Studies
- Inflammatory mediators and NSAID effects
- Pain Mechanisms and Treatments
- Streptococcal Infections and Treatments
- FOXO transcription factor regulation
University of Minnesota Medical Center
2021-2025
University of Minnesota
1995-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Jinhua Academy of Agricultural Sciences
2020
Resonance Research (United States)
1995-1996
Twin Cities Orthopedics
1996
Tissue-resident macrophages in the mammary gland are found close association with epithelial structures and within adipose stroma, important for development tissue homeostasis. Macrophages have been linked to ductal virgin gland, but less is known regarding effects of on stroma. Using transcriptional profiling single-cell RNA sequencing approaches, we identify a distinct resident stromal macrophage subpopulation mouse nulliparous that characterized by expression Lyve-1, receptor...
Abstract While macrophages are among the most abundant immune cell type found within primary and metastatic mammary tumors, how their complexity heterogeneity change with progression remains unknown. Here, were isolated from lungs of mice bearing orthotopic tumors for single-cell RNA sequencing (scRNA-seq). Seven distinct macrophage clusters identified, including populations exhibiting enhanced differential expression genes related to antigen presentation (H2-Aa, Cd74), cycle (Stmn1, Cdk1),...
Abstract The authors investigated the utility of an intra‐vascular magnetic resonance (MR) contrast agent, poly‐L‐lysine‐gadolinium diethylenetriaminepentaacetic acid (DTPA), for differentiating acutely ischemic from normally perfused myocardium with first‐pass MR imaging. Hypoperfused regions, identified microspheres, on images displayed significantly decreased signal intensities compared ( P < 0.0007). Estimates regional myocardial blood content, obtained by measuring ratio areas under...
Background The underlying mechanisms by which left ventricular remodeling (LVR) leads to congestive heart failure (CHF) are unclear. This study examined the functional and bioenergetic abnormalities associated with postinfarction in a new, large animal model. Methods Results Remodeling was induced circumflex coronary artery ligation young pigs. LV mass, volume, ejection fraction (EF), ratio of scar surface area area, wall stresses were calculated from magnetic resonance imaging anatomic data...
Tumor-associated macrophages contribute to tumor progression and therapeutic resistance in breast cancer. Within the microenvironment, tumor-derived factors activate pathways that modulate macrophage function. Using vitro vivo models, we find induce activation of Janus kinase (JAK)/signal transducer activator transcription 3 (STAT3) pathway macrophages. We also demonstrate loss STAT3 myeloid cells leads enhanced mammary tumorigenesis. Further studies show tumors JAK/STAT inhibitor...
Abstract MRI studies of first‐pass contrast enhancement with polylysine‐Gd‐DTPA and myocardial tagging using spatial modulation magnetization (SPAMM) were performed to assess the feasibility a combined regional blood flow 2D deformation exam. Instrumented closed‐chest dogs imaged at baseline control state (Cntl) followed by two interventions: moderate coronary stenosis (St) achieved partial occlusion left anterior descending (LAD) dobutamine loading (StD). Hypoperfusion region (ANT)...
Vascular complications of diabetes are a serious challenge in clinical practice, and effective treatments an unmet need. Acidic fibroblast growth factor (aFGF) has potent anti-oxidative properties therefore become research focus for the treatment diabetic vascular complications. However, specific mechanisms by which aFGF regulates these processes remain unclear. The purpose this study was to investigate whether alleviates endothelial dysfunction suppressing mitochondrial oxidative stress. We...
Abstract Signaling by fibroblast growth factor receptors (FGFRs) is active in up to 85% of breast cancers and results enhanced proliferation, migration, invasion tumor cells. Here, we show that FGFR signaling regulates cholesterol metabolism cancer. Specifically, demonstrate activation promotes cellular storage upregulating expression the enzyme sterol O-acyltransferase 1 (SOAT1). Moreover, inhibition SOAT1 attenuates FGFR-driven colony formation Finally, identify a relationship between...
Integrative approaches such as electroacupuncture, devoid of drug effects are gaining prominence for treating pain. Understanding the mechanisms electroacupuncture induced analgesia would benefit chronic pain conditions sickle cell disease (SCD), which patients may require opioid analgesics throughout life. Mouse models instructive in developing a mechanistic understanding pain, but anesthesia/restraint required to administer alter underlying mechanisms. To overcome these limitations, we...
A pediatric patient suffered from renal and hepatic abscesses (through hepatorenal space) recovered by antibiotics other therapies. By clinical analysis, the multi-organ might be caused bloodstream-disseminated infection. In order to identify pathogen, we collected kidney biopsy tissue, swabs, plasma samples, used metagenomics next-generation sequencing (mNGS) some traditional methods. The results revealed that polymicrobial especially anaerobic bacteremia (Bacteroides fragilis, et al.)...
<div>Abstract<p>While macrophages are among the most abundant immune cell type found within primary and metastatic mammary tumors, how their complexity heterogeneity change with progression remains unknown. Here, were isolated from lungs of mice bearing orthotopic tumors for single-cell RNA sequencing (scRNA-seq). Seven distinct macrophage clusters identified, including populations exhibiting enhanced differential expression genes related to antigen presentation (<i>H2-Aa,...
<p>Figure legends for Supplementary Data</p>
<p>Differential gene expression analysis of biological replicate 1.</p>
<p>Differential gene expression analysis of biological replicate 1.</p>
<p>Gene set enrichment analysis of LAM vs. AM IM.</p>
<p>Figure legends for Supplementary Data</p>
<p>Figure S3 shows our flow cytometry gating and quantification of LAM in primary tumors at a pre-metastatic timepoint.</p>
<p>Differential gene expression analysis of biological replicate 2.</p>
<p>Differential gene expression analysis of biological replicate 2.</p>
<p>Figure S4 shows metastasis data following clodronate administration and characterization of lipid-loaded BMDMs.</p>
<p>Figure S4 shows metastasis data following clodronate administration and characterization of lipid-loaded BMDMs.</p>
<p>Figure S3 shows our flow cytometry gating and quantification of LAM in primary tumors at a pre-metastatic timepoint.</p>
<p>Gene set enrichment analysis of cluster 6 compared to gene sets from a published manuscript and MSigDB.</p>