A5081896107- Fungal and yeast genetics research
- Fermentation and Sensory Analysis
- Yeasts and Rust Fungi Studies
- Evolution and Genetic Dynamics
- Trypanosoma species research and implications
- Cardiomyopathy and Myosin Studies
- Viral Infections and Immunology Research
- Horticultural and Viticultural Research
Fondation ARC pour la Recherche sur le Cancer
2021
Institut de Recherche sur le Cancer et le Vieillissement de Nice
2018-2020
Inserm
2018-2020
Université Côte d'Azur
2018-2020
Centre National de la Recherche Scientifique
2018-2020
Aix-Marseille Université
2013
Large-scale population genomic surveys are essential to explore the phenotypic diversity of natural populations. Here we report whole-genome sequencing and phenotyping 1,011 Saccharomyces cerevisiae isolates, which together provide an accurate evolutionary picture variants that shape species-wide landscape this yeast. Genomic analyses support a single ‘out-of-China’ origin for species, followed by several independent domestication events. Although domesticated isolates exhibit high variation...
AimsChagas disease, caused by the protozoan Trypanosoma cruzi is endemic in Latin America, and may lead to a life-threatening inflammatory dilated, chronic Chagas cardiomyopathy (CCC). One third of T. cruzi-infected individuals progress CCC while others remain asymptomatic (ASY). A possible genetic component disease progression was suggested familial aggregation cases association markers innate adaptive immunity genes with development. Since mutations multiple sarcomeric genes, including...
Abstract Hybrids between diverged lineages contain novel genetic combinations but an impaired meiosis often makes them evolutionary dead ends. Here, we explore to what extent aborted followed by a return-to-growth (RTG) promotes recombination across panel of 20 Saccharomyces cerevisiae and S. paradoxus diploid hybrids with different genomic structures levels sterility. Genome analyses 275 clones reveal that RTG generates extensive regions loss-of-heterozygosity in sterile either defective or...
Abstract Hybrids between species or diverged lineages contain fundamentally novel genetic combinations but an impaired meiosis often makes them evolutionary dead ends. Here, we explored to what extent and how aborted followed by a return-to-growth (RTG) promotes recombination across panel of 20 yeast diploid backgrounds with different genomic structures levels sterility. Genome analyses 284 clones revealed that RTG promoted generated extensive regions loss-of-heterozygosity in sterile...